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Transient receptor potential canonical 6 knockdown ameliorated diabetic kidney disease by inhibiting nuclear factor of activated T cells 2 expression in glomerular mesangial cells
CONCLUSION: These results demonstrate that inhibition of TRPC6/NFAT2 signaling attenuates GMC dysfunction and the development of DKD and suggest that pharmacological targeting of TRPC6/NFAT2 in GMCs may provide beneficial effects for DKD.PMID:36285371 | DOI:10.1080/0886022X.2022.2134796
Source: Renal Failure - October 26, 2022 Category: Urology & Nephrology Authors: Jian Yu Chunchun Li Lisha Ma Bin Zhai Aiping Xu Decui Shao Source Type: research

Vitamin D/vitamin D receptor/Atg16L1  axis maintains podocyte autophagy and survival in diabetic kidney disease
CONCLUSION: Autophagy protects podocytes from damage in DN and is modulated by VitD3/VDR signaling and downstream regulation of Atg16L1 expression.PMID:35469547 | DOI:10.1080/0886022X.2022.2063744
Source: Renal Failure - April 26, 2022 Category: Urology & Nephrology Authors: Lang Shi Chao Xiao Yafei Zhang Yao Xia Hongchu Zha Jiefu Zhu Zhixia Song Source Type: research

ATF4-dependent heme-oxygenase-1 attenuates diabetic nephropathy by inducing autophagy and inhibiting apoptosis in podocyte
CONCLUSIONS: ATF4 induces autophagy by enhancing the expression of HO-1, and inhibits podocyte apoptosis in DN. Treatment with the HO-1 agonist reduced proteinuria, apoptosis, and enhanced autophagy response, and thus improved renal function in DN mice.PMID:34157937 | DOI:10.1080/0886022X.2021.1936040
Source: Renal Failure - June 23, 2021 Category: Urology & Nephrology Authors: Shizhu Yuan Xudong Liang Wenfang He Mingzhu Liang Juan Jin Qiang He Source Type: research

Vitamin D protects glomerular mesangial cells from high glucose-induced injury by repressing JAK/STAT signaling
ConclusionVitamin D (VD) treatment inhibits the function of HG on fibronectin production through regulating JAK/STAT pathway. These results provide direct evidences that VD protects glomerular mesangial cells from high glucose-induced injury through repressing JAK/STAT signaling, which has the potential for clinical DN treatment.
Source: International Urology and Nephrology - May 3, 2021 Category: Urology & Nephrology Source Type: research

AGE-Induced Suppression of EZH2 Mediates Injury of Podocytes by Reducing H3K27me3.
CONCLUSIONS: Our studies provide a novel pathway how AGEs contribute to podocyte injury and the formation of the so-called metabolic memory in DKD. PMID: 32854097 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - August 26, 2020 Category: Urology & Nephrology Authors: Liebisch M, Wolf G Tags: Am J Nephrol Source Type: research

Preconditioning of adipose ‐derived stem cells by phosphodiesterase‐5 inhibition enhances therapeutic efficacy against diabetes‐induced erectile dysfunction
ConclusionsAdipose ‐derived stem cell therapy could serve as an alternate approach for diabetes‐induced erectile dysfunction, albeit with a long onset period.In vitro preconditioning of adipose ‐derived stem cells could accelerate the functional and structural recoveryin vivo, indicating that preconditioning by inhibition of phosphodiesterase type 5 may improve adipose ‐derived stem cells therapy following diabetes‐induced erectile dysfunction.
Source: Andrology - June 18, 2019 Category: Urology & Nephrology Authors: J. Yang, Z. Yu, Y. Zhang, G. ‐H. Zang, L. Zhuan, Z. Tang, Y. Liu, T. Wang, S.‐G. Wang, J.‐H. Liu Tags: Original Article Source Type: research

The Role of Palladin in Podocytes
Conclusions Palladin has an important role in podocyte function in vitro and in vivo.
Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Artelt, N., Ludwig, T. A., Rogge, H., Kavvadas, P., Siegerist, F., Blumenthal, A., van den Brandt, J., Otey, C. A., Bang, M.-L., Amann, K., Chadjichristos, C. E., Chatziantoniou, C., Endlich, K., Endlich, N. Tags: Basic Research Source Type: research

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