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MicroRNA-137 Inhibited Hypoxia-Induced Proliferation of Pulmonary Artery Smooth Muscle Cells by Targeting Calpain-2
In this study, male Sprague-Dawley rats were subjected to 10% O2 for 3 weeks to establish PH, and rat primary PASMCs were treated with hypoxia (3% O2) for 48 h to induce cell proliferation. The effect of miR-137 on PASMC proliferation and calpain-2 expression was assessed by transfecting miR-137 mimic and inhibitor. The effect of calpain-2 on PASMC proliferation was assessed by transfecting calpain-2 siRNA. The present study found for the first time that miR-137 was downregulated in pulmonary arteries of hypoxic PH rats and in hypoxia-treated PASMCs. miR-137 mimic inhibited hypoxia-induced PASMC proliferation and upregulat...
Source: Biomed Res - September 13, 2021 Category: Research Authors: Xiao-Yue Ge Tian-Tian Zhu Mao-Zhong Yao Hong Liu Qian Wu Jie Qiao Wei-Fang Zhang Chang-Ping Hu Source Type: research

TMEM16A Regulates Pulmonary Arterial Smooth Muscle Cells Proliferation via p38MAPK/ERK Pathway in High Pulmonary Blood Flow-Induced Pulmonary Arterial Hypertension
Conclusion: TMEM16A regulates PASMCs proliferation in high pulmonary blood flow-induced PAH, and the p38MAPK/ERK signaling pathway is probably involved.J Vasc Res
Source: Journal of Vascular Research - December 11, 2020 Category: Research Source Type: research

Involvement of TRPC1 and Cyclin D1 in Human Pulmonary Artery Smooth Muscle Cells Proliferation Induced by Cigarette Smoke Extract
SummaryCigarette smoking contributes to the development of pulmonary artery hypertension (PAH). As the basic pathological change of PAH, pulmonary vascular remodeling is considered to be related to the abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs). However, the molecular mechanism underlying this process remains not exactly clear. The aim of this research was to study the molecular mechanism of PASMCs proliferation induced by smoking. Human PASMCs (HPASMCs) were divided into 6 groups: 0% (control group), cigarette smoking extract (CSE)-treated groups at concentrations of 0.5%, 1%, 2%, 5%, 10% CSE ...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - December 1, 2020 Category: Research Source Type: research

Effect of Aldosterone on Senescence and Proliferation Inhibition of Endothelial Progenitor Cells Induced by Sirtuin 1 (SIRT1) in Pulmonary Arterial Hypertension.
CONCLUSIONS ALDO promoted EPCs senescence and inhibited EPCs proliferation by downregulating SIRT1, which regulates the p53/p21 pathway, thus promoting PAH. PMID: 32303670 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - April 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

MicroRNA-214-3p Regulates Hypoxia-Mediated Pulmonary Artery Smooth Muscle Cell Proliferation and Migration by Targeting ARHGEF12.
CONCLUSIONS In conclusion, these results indicate that miR-214-3p acts as a novel regulator of hypoxia-induced proliferation and migration by directly targeting ARHGEF12 and dysregulating c-jun and c-fos in PASMCs, and may be a potential therapeutic target for treating pulmonary hypertension. PMID: 31373336 [PubMed - in process]
Source: Medical Science Monitor - August 3, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Dab1 Contributes to Angiotensin II-Induced Apoptosis via p38 Signaling Pathway in Podocytes.
Abstract Numerous studies have found that angiotensin II (Ang II) participates in podocyte apoptosis and exacerbates progression of end-stage kidney disease (ESKD). However, its underlying mechanism remains largely unexplored. As a homolog of Drosophila disabled (Dab) protein, Dab1 plays a vital role in cytoskeleton, neuronal migration, and proliferation. In the present study, our data revealed that Ang II-infused rats developed hypertension, proteinuria, and podocyte injury accompanied by Dab1 phosphorylation and increased reelin expression in kidney. Moreover, Ang II induced podocyte apoptosis in vitro. Dab1 pho...
Source: Biomed Res - July 7, 2017 Category: Research Authors: Gao Z, Chen X, Zhu K, Zeng P, Ding G Tags: Biomed Res Int Source Type: research

rs10719 Polymorphism Located within DROSHA 3'-Untranslated Region is Responsible for Development of Primary Hypertension by Disrupting Binding with microRNA-27b.
CONCLUSIONS The presence of rs10719 disrupted the interaction between miR-27b and DROSHA, which might be the underlying mechanism of the observation that rs10719 is significantly associated with risk of primary hypertension. PMID: 28214904 [PubMed - in process]
Source: Medical Science Monitor - February 20, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications.
In conclusion, cancer and PAH share acquired mitochondrial abnormalities that increase proliferation and inhibit apoptosis, suggesting new therapeutic targets. PMID: 27343087 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - June 29, 2016 Category: Research Tags: Adv Exp Med Biol Source Type: research

Id: 119: pathogenic roles of calcium-sensing receptors and transient receptor potential canonical channels 6 in the development and progression of pulmonary hypertension
Conclusions These data indicate that functional interaction of upregulated CaSR and upregulated TRPC6 in PASMC from IPAH patients and animals with experimental PH may play an important role in the development and progression of sustained pulmonary vasoconstriction and pulmonary vascular remodeling. Blockade or downregulation of CaSR and/or TRPC6 with siRNA or miRNA may be a novel therapeutic strategy to develop new drugs for patients with pulmonary arterial hypertension. Keywords G protein-coupled receptor; ionic ligand; hypoxia-induced pulmonary hypertension.
Source: Journal of Investigative Medicine - March 21, 2016 Category: Research Authors: TANG, H., Gu, Y., Black, S., Garcia, J., Makino, A., Yuan, J., Yamamura, A., Fraidenburg, D., Chen, J. Tags: Pulmonary/Critical Care Source Type: research

The association between BMP4 gene polymorphism and its serum level with the incidence of LVH in hypertensive patients
Background: Bone morphogenic proteins 4 (BMP4) is associated with cardiac remodeling under different conditions. However, the role of BMP4 and its gene polymorphism in the incidence of left ventricular hypertrophy (LVH) in hypertensive patients remains unknown. Methods: A total of 1265 patients diagnosed with essential hypertension (EH) were recruited. Patients were assigned to LVH+ (n?=?420) and LVH- (n?=?845) groups. serum BMP4 level was measured and two single nucleotide polymorphism (SNPs) polymorphisms, 6007C?>?T and -5826G?>?A of BMP4 gene were genotyped. We also inhibited the BMP4 by small interfering RNA (siRNA). T...
Source: Journal of Translational Medicine - January 16, 2015 Category: Research Authors: GL GuQY YangRL ZengXL Xu Source Type: research