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Total 46 results found since Jan 2013.

USP10 regulates macrophage inflammation responses via stabilizing NEMO in LPS-induced sepsis
ConclusionsOverall, USP10 was shown to regulate inflammatory responses by stabilizing the NEMO protein, which may be a potential therapeutic target for sepsis-induced lung injury.
Source: Inflammation Research - July 12, 2023 Category: Research Source Type: research

Inhibition of importin-7 attenuates ventilator-induced lung injury by targeting nuclear translocation of p38
ConclusionsOur findings uncover a key role for Imp7 in the process of p38 nuclear import after CS stimulation and highlight the potential of preventing p38 nuclear translocation in treatment of VILI.
Source: Inflammation Research - April 1, 2023 Category: Research Source Type: research

Glycyrrhizic acid promotes sciatic nerves recovery in type 1 diabetic rats and protects Schwann cells from high glucose-induced cytotoxicity
J Biomed Res. 2022 May 15:1-14. doi: 10.7555/JBR.36.20210198. Online ahead of print.ABSTRACTThe present study aims to investigate the therapeutic effect and mechanism of glycyrrhizic acid (GA) in diabetic peripheral neuropathy (DPN). GA significantly mitigated nerve conduction velocity (NCV) deficit and morphological abnormality and reduced high-mobility group box-1 (HMGB1) expression in the sciatic nerves of diabetic rats independent of blood glucose and body weight. Notably, GA alleviated the increase of HMGB1 and the decrease of cell viability in high glucose-stimulated RSC96 cells. Furthermore, GA obviously reduced the...
Source: Biomed Res - May 17, 2022 Category: Research Authors: Min Shi Xiangcheng Zhang Ridong Zhang Hong Zhang Dalong Zhu Xiao Han Source Type: research

IGF-1R/YAP signaling pathway is involved in collagen V-induced insulin biosynthesis and secretion in rat islet INS-1 cells
CONCLUSION: Inhibition of IGF-1 R/YAP signal pathway is involved in collagen V-induced insulin biosynthesis and secretion in INS-1 cells.PMID:35129018 | DOI:10.1080/03008207.2021.2025225
Source: Connective Tissue Research - February 7, 2022 Category: Research Authors: Yingying Zhu Shuaigao Chen Weiwei Liu Fanxing Xu Jingyu Lu Toshihiko Hayashi Kazunori Mizuno Shunji Hattori Hitomi Fujisaki Takashi Ikejima Source Type: research

Protective Effects of 1,25 Dihydroxyvitamin D < sub > 3 < /sub > against High-Glucose-Induced Damage in Human Umbilical Vein Endothelial Cells Involve Activation of Nrf2 Antioxidant Signaling
Conclusions: 1,25(OH)2D3 attenuates high-glucose-induced endothelial oxidative injury through upregulation of the Nrf2 antioxidant pathway in a VDR-dependent manner.J Vasc Res
Source: Journal of Vascular Research - May 4, 2021 Category: Research Source Type: research

Mitochondria and nucleus cross ‐talk: Signaling in metabolism, apoptosis, and differentiation, and function in cancer
AbstractThe cross ‐talk between the mitochondrion and the nucleus regulates cellular functions, including differentiation and adaptation to stress. Mitochondria supply metabolites for epigenetic modifications and other nuclear‐associated activities and certain mitochondrial proteins were found in the nucleus. The voltage‐dependent anion channel 1 (VDAC1), localized at the outer mitochondrial membrane (OMM) is a central protein in controlling energy production, cell growth, Ca2+ homeostasis, and apoptosis. To alter the cross ‐talk between the mitochondria and the nucleus, we used specific siRNA to silence the expres...
Source: IUBMB Life - November 12, 2020 Category: Research Authors: Anna Shteinfer ‐Kuzmine, Ankit Verma, Tasleem Arif, Or Aizenberg, Avijit Paul, Varda Shoshan‐Barmaz Tags: RESEARCH COMMUNICATION Source Type: research

Cordycepin inhibits human ovarian cancer by inducing autophagy and apoptosis through Dickkopf-related protein 1/ β-catenin signaling.
In this study, we treated human ovarian cancer cells with different doses of cordycepin and found that it dose-dependently reduced ovarian cancer cell viability, based on Cell counting kit-8 reagent. Immunoblotting showed that cordycepin increased Dickkopf-related protein 1 (Dkk1) levels and inhibited β-catenin signaling. Atg7 knockdown in ovarian cancer cells significantly inhibited cordycepin-induced apoptosis, whereas β-catenin overexpression abolished the effects of cordycepin on cell death and proliferation. Furthermore, we found that Dkk1 overexpression by transfection downregulated the expression of c-Myc and cycl...
Source: American Journal of Translational Research - December 10, 2019 Category: Research Tags: Am J Transl Res Source Type: research

CRISPR/Cas9 Knockout of Bak Mediates Bax Translocation to Mitochondria in response to TNF α/CHX-induced Apoptosis.
In this study, we used the CRISPR/Cas9 system to knockout Bak in the human SH-SY5Y cell line and determined the effects of this knockout on TNFα/CHX-induced apoptosis. Our data showed that overexpression of Bcl-2 dramatically prevented TNFα/CHX-induced apoptosis, and then pro-apoptotic protein Bak was downregulated and became more resistant to TNFα/CHX-induced apoptosis, because both TNFα/CHX-induced PARP cleavage and caspase activation were blocked in BAK-/- cells or using specific siRNA, whereas Bax was dispensable in TNFα/CHX-induced apoptosis, as evidenced using specific siRNA. Bax translocated from the cytosol in...
Source: Biomed Res - October 23, 2019 Category: Research Authors: Zhang J, Niu H, Zhao ZJ, Fu X, Wang Y, Zhang X, Zhang F, Zeng L Tags: Biomed Res Int Source Type: research

Curcumin Inhibits Cell Viability and Increases Apoptosis of SW620 Human Colon Adenocarcinoma Cells via the Caudal Type Homeobox-2 (CDX2)/Wnt/ β-Catenin Pathway.
CONCLUSIONS Curcumin reduced cell viability and increased apoptosis in SW620 human colonic adenocarcinoma cells by restoring CDX2, which inhibited the Wnt/ß-catenin signaling pathway. PMID: 31584928 [PubMed - in process]
Source: Medical Science Monitor - October 6, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Fbxw7 and Skp2 Regulate Stem Cell Switch between Quiescence and Mitotic Division in Lung Adenocarcinoma.
Conclusion: 5-FU enriches the CSCs in lung adenocarcinoma cells via increasing Fbxw7 and decreasing Skp2 expression, followed by downregulation of c-myc and upregulation of p27, which switches cells to quiescence. PMID: 31534970 [PubMed - in process]
Source: Biomed Res - September 21, 2019 Category: Research Authors: Zhang W, Ren Z, Jia L, Li X, Jia X, Han Y Tags: Biomed Res Int Source Type: research

Human amnion ‐derived mesenchymal stem cells enhance the osteogenic differentiation of human adipose‐derived stem cells by promoting adiponectin excretion via the APPL1‐ERK1/2 signaling pathway
In this study, HAMSCs concentration‐dependently induced growth, osteoblastic differentiation, and APN excretion in HASCs. Mechanistically, immunofluorescence and immunoblot revealed HAMSCs promoted cytosolic translocation of leucine zipper motif (APPL1) from the nucleus and induced extracellular signaling‐regulated kinase 1/2 (ERK1/2) phosphorylation in HASCs. Furthermore, HAMSC effects were markedly blunted by pretreatment with APPL1 siRNA and U0126, an ERK1/2 signaling inhibitor with high selectivity. These resul ts suggested that APN excretion is not suppressed by APPL1 knockdown in HASCs, but by ERK1/2 inhibition. ...
Source: IUBMB Life - September 10, 2019 Category: Research Authors: Yuli Wang, Yifei Du, Hua Yuan, Yongchu Pan, Jun Wu, Xin Du, Shushu Hao, Zixin Yan, Xuan Li, Keyue Liu, Fan Xu Tags: RESEARCH COMMUNICATION Source Type: research