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Specialty: Research
Condition: Cholesterol
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Total 22 results found since Jan 2013.
High interindividual variability in LDL-cholesterol reductions after inclisiran administration in a real-world multicenter setting in Germany
CONCLUSION: In this real-world patient population referred to German lipid clinics for elevated LDL-C levels, inclisiran demonstrated a high interindividual variability in LDL-C reductions. Further research is warranted to elucidate reasons for the interindividual variability in drug efficacy.PMID:37422840 | DOI:10.1007/s00392-023-02247-8
Source: Clin Med Res - July 9, 2023 Category: Research Authors: U Makhmudova U Schatz N Perakakis U Kassner F Schumann C Axthelm P St ürzebecher D L Sinning A Doevelaar B Rohn T Westhoff A Vogt M Scholl U K ästner J-A Geiling K Stach J Mensch E Lorenz C Paitazoglou I Eitel A Baessler E Steinhagen-Thiessen W Koenig P Source Type: research
TRPV1 Protect against Hyperglycemia and Hyperlipidemia Induced Liver Injury via OPA1 in Diabetes
In conclusion, our study showed that the identified regulation of TRPV1 to OPA1 has important implication to the pathogenesis of T2DM-associated liver injury. Targeting the action of TRPV1 and OPA1 presents a potential therapeutic intervention.PMID:35197406 | DOI:10.1620/tjem.256.131
Source: The Tohoku Journal of Experimental Medicine - February 24, 2022 Category: Research Authors: Ting Wang Yingmei Chen Yong Li Zhen Wang Chenming Qiu Dachun Yang Ken Chen Source Type: research
Investigation of water-insoluble hydrophobic polyethylenimines as RNAi vehicles in chronic myeloid leukemia therapy
J Biomed Mater Res A. 2021 May 8. doi: 10.1002/jbm.a.37214. Online ahead of print.ABSTRACTThe discovery of RNA interference (RNAi) more than two decades ago opened avenues for avant-garde cancer treatments that possess the ability to evade issues hampering current chemotherapeutic strategies, owing to its specific gene sequence-driven mechanism of action. A potent short interfering RNA (siRNA) delivery vehicle designed to overcome physiological barriers is imperative for successful RNAi therapy. For this purpose, this study explored the characteristics and therapeutic efficacy of low-molecular weight (MW) polyethylenimine ...
Source: Biomed Res - May 8, 2021 Category: Research Authors: Aysha S Ansari Remant K C Xiaoyan Jiang Hasan Uluda ǧ Source Type: research
FOXO3a regulates lipid accumulation and adipocyte inflammation in adipocytes through autophagy
ConclusionFOXO3a could promote lipid accumulation and inflammation in differentiated 3T3-L1 adipocytes by targeting autophagy. Our results provide a new theoretical basis for FOXO3a to regulate obesity.
Source: Inflammation Research - April 23, 2021 Category: Research Source Type: research
Resveratrol improves high-fat diet-induced insulin resistance in mice by downregulating the lncRNA NONMMUT008655.2.
The objective of this study was to investigate whether RSV improves high-fat diet-induced insulin resistance in mice by regulating thelncRNANONMMUT008655.2 in vivo and in vitro. To this end, animal and cell insulin resistance models were developed. Specifically, C57BL/6J mice were fed a high-fat diet (HFD) and administered RSV for eight weeks. Additionally, mouse Hepa cells were treated with palmitic acid, transfected with siRNA NONMMUT008655.2, and treated with RSV. Treated mice and cells were then compared to normal controls that were not exposed to RSV. In the animal model, RSV was found to decrease the levels of fastin...
Source: American Journal of Translational Research - February 15, 2020 Category: Research Tags: Am J Transl Res Source Type: research
Cholesterol Grafted Cationic Lipopolymers: Potential siRNA Carriers for Selective Chronic Myeloid Leukemia (CML) Therapy.
This article is protected by copyright. All rights reserved.
PMID: 31714657 [PubMed - as supplied by publisher]
Source: Biomed Res - November 11, 2019 Category: Research Authors: Remant KC, Thapa B, Valencia-Serna J, Domun SS, Dimitroff C, Jiang X, Uludağ H Tags: J Biomed Mater Res A Source Type: research
Silencing of GPR82 with Interference RNA Improved Metabolic Profiles in Rats with High Fructose Intake
Metabolic syndrome (MS) is a clinical condition, constituted by alterations that lead to the onset of type II diabetes and cardiovascular disease. It has been reported that orphan G-protein-coupled receptor 82 (GPR82) participates in metabolic processes. The aim of this study was to evaluate the function of GPR82 in MS using a small interfering RNA (siRNA) against this receptor. We used Wistar rats of 10–12 weeks of age fed with a high-fructose solution (70%) for 9 weeks to induce MS. Subsequently, the rats were treated with an intrajugular dose of an siRNA against GPR82 and the effects were evaluated on day 3 and 7 af...
Source: Journal of Vascular Research - July 2, 2019 Category: Research Source Type: research
An Inhibitor of Activated Blood Coagulation Factor X Shows Anti-Endothelial Senescence and Anti-Atherosclerotic Effects
Conclusion: Rivaroxaban prevents replicative senescence in HUVECs and aortic endothelial cells in dyslipidemic diabetic mice. It restores endothelial function and prevents the progression of atherosclerosis.J Vasc Res
Source: Journal of Vascular Research - July 2, 2019 Category: Research Source Type: research
Silencing the ACAT1 Gene in Human SH-SY5Y Neuroblastoma Cells Inhibits the Expression of Cyclo-Oxygenase 2 (COX2) and Reduces β-Amyloid-Induced Toxicity Due to Activation of Protein Kinase C (PKC) and ERK.
CONCLUSIONS Silencing ACAT1 attenuates Aβ₂₅₋₃₅-induced cytotoxicity and cell apoptosis in SH-SY5Y cells, which may due to the synergistic effect of ACAT1 and COX2 through PKC/ERK pathways.
PMID: 30541014 [PubMed - in process]
Source: Medical Science Monitor - December 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research
