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Total 139 results found since Jan 2013.

A Systematic Review of Second-Line Treatments in Antiviral Resistant Strains of HSV-1, HSV-2, and VZV
The objective of this study was to evaluate available literature on the possible efficacy of second-line treatments in HSV and the use of second-line treatments in HSV strains that are resistant to first-line treatments. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a final search was conducted in six databases on November 5, 2021 for all relevant literature using terms related to antiviral resistance, herpes, and HSV. Eligible manuscripts were required to report the presence of an existing or proposed second-line treatment for HSV-1, HSV-2, or varicella zoster virus (VZV...
Source: Herpes - April 12, 2023 Category: Infectious Diseases Authors: Kimberly C Lince Virgil K DeMario George T Yang Rita T Tran Daniel T Nguyen Jacob N Sanderson Rachel Pittman Rebecca L Sanchez Source Type: research

Effect of RNA interference with glutamate decarboxylase on acid resistance of Trichinella spiralis
Acta Trop. 2023 Feb 25:106869. doi: 10.1016/j.actatropica.2023.106869. Online ahead of print.ABSTRACTTrichinella spiralis is a zoonotic parasite that infects most mammals, even humans. Glutamate decarboxylase (GAD) is an important enzyme in glutamate-dependent acid resistance system 2 (AR2), but the GAD of T. spiralis in AR2 is unclear. We aimed to investigate the role of T. spiralis glutamate decarboxylase (TsGAD) in AR2. We silenced the TsGAD gene to evaluate the AR of T. spiralis muscle larvae (ML) in vivo and in vitro via siRNA. The results showed that recombinant TsGAD was recognized by anti-rTsGAD polyclonal antibody...
Source: Acta Tropica - February 27, 2023 Category: Infectious Diseases Authors: Jiaming Hou Shi Meng Bohan Zhang Rulin Ruan Yan Zhang Ze Wang Mingxin Song Zhikun Bai Source Type: research

Synergistic antitumor effect of histone deacetylase class IIa inhibitor with lenvatinib in hepatocellular carcinoma
ConclusionClass IIa HDACI and lenvatinib combination therapy induces apoptosis by downregulating FGFR4 and blocking the FGFR signaling in FGFR4-positive HCC cell lines and has demonstrated synergistic antitumor effects and safety. This combination therapy overcomes the problems of conventional therapies and will be beneficial for FGFR4-positive HCC patients.
Source: Hepatology International - February 4, 2023 Category: Infectious Diseases Source Type: research

Supportive Oligonucleotide Therapy (SOT) as a Potential Treatment for Viral Infections and Lyme Disease: Preliminary Results
This study revealed that for Lyme Disease, one or two SOT administrations can lead to a statistically significant decrease in DNA copies, while for viruses, two or three administrations are required to achieve a statistically significant reduction in the genetic material. These preliminary results indicate that antisense SOT therapy can be considered a potential treatment for viral as well as Lyme diseases.PMID:36412742 | DOI:10.3390/idr14060084
Source: Herpes - November 22, 2022 Category: Infectious Diseases Authors: Panagiotis Apostolou Aggelos Iliopoulos Georgios Beis Ioannis Papasotiriou Source Type: research

Silencing of proinflammatory NF- κB and inhibition of herpes simplex virus (HSV) replication by ultrasmall gold nanoparticles (2 nm) conjugated with small-interfering RNA
Nanoscale Adv. 2022 Sep 5;4(21):4502-4516. doi: 10.1039/d2na00250g. eCollection 2022 Oct 25.ABSTRACTAzide-terminated ultrasmall gold nanoparticles (2 nm gold core) were covalently functionalized with alkyne-terminated small-interfering siRNA duplexes by copper-catalyzed azide-alkyne cycloaddition (CuAAC; click chemistry). The nanoparticle core was visualized by transmission electron microscopy. The number of attached siRNA molecules per nanoparticle was determined by a combination of atomic absorption spectroscopy (AAS; for gold) and UV-Vis spectroscopy (for siRNA). Each nanoparticle carried between 6 and 10 siRNA duplex m...
Source: Herpes - November 7, 2022 Category: Infectious Diseases Authors: Natalie Wolff Sebastian Kollenda Kai Klein Kateryna Loza Marc Heggen Leonie Brochhagen Oliver Witzke Adalbert Krawczyk Ingrid Hilger Matthias Epple Source Type: research

Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy
Autophagy. 2022 Nov 7:1-21. doi: 10.1080/15548627.2022.2139921. Online ahead of print.ABSTRACTAlpha-herpesvirus causes lifelong infections and serious diseases in a wide range of hosts and has developed multiple strategies to counteract the host defense. Here, we demonstrate that the tegument protein UL21 (unique long region 21) in pseudorabies virus (PRV) dampens type I interferon signaling by triggering the degradation of CGAS (cyclic GMP-AMP synthase) through the macroautophagy/autophagy-lysosome pathway. Mechanistically, the UL21 protein scaffolds the E3 ligase UBE3C (ubiquitin protein ligase E3C) to catalyze the K27-l...
Source: Herpes - November 7, 2022 Category: Infectious Diseases Authors: Zicheng Ma Juan Bai Chenlong Jiang Huixin Zhu Depeng Liu Mengjiao Pan Xianwei Wang Jiang Pi Ping Jiang Xing Liu Source Type: research

Analysis of the Function of LncRNA- < em > MSTRG.16919.1 < /em > in BHV-1-Infected Bovine Kidney Subculture Cells by Transcriptome Sequencing
Viruses. 2022 Sep 22;14(10):2104. doi: 10.3390/v14102104.ABSTRACTInfection of cattle with bovine herpesvirus type 1 (BHV-1) can lead to upper respiratory tract disease, conjunctivitis, or genital disease and cause serious economic losses to the cattle industry worldwide. The role of long noncoding RNAs in BHV-1 infection is not well understood. To explore the role of lncRNA-MSTRG.16919.1 in bovine herpes virus type I (BHV-1) infected MDBK cells, the lncRNA-MSTRG.16919.1 gene was silenced and sequenced transcriptome and sequencing data were analyzed by Edge R software, Gene Ontology (GO), the Kyoto Encyclopedia of Genes and...
Source: Herpes - October 27, 2022 Category: Infectious Diseases Authors: Fan Zhang Kunsheng Jiang Yuchun Wang Jinzhu Ma Baifen Song Source Type: research

Host Cell Neddylation Facilitates Alphaherpesvirus Entry in a Virus-Specific and Cell-Dependent Manner
Microbiol Spectr. 2022 Sep 29:e0311422. doi: 10.1128/spectrum.03114-22. Online ahead of print.ABSTRACTHerpes simplex virus 1 (HSV-1) commandeers the host cell proteasome at several steps of its replication cycle, including entry. Here we demonstrate that HSV-2, pseudorabies virus (PRV), and bovine herpesvirus 1 (BoHV-1) entry are blocked by bortezomib, a proteasome inhibitor that is an FDA-approved cancer drug. Proteasome-dependent entry of HSV-1 is thought to be ubiquitin-independent. To interrogate further the proteasomal mechanism of entry, we determined the involvement of the ubiquitin-like molecule NEDD8 and the neddy...
Source: Herpes - September 29, 2022 Category: Infectious Diseases Authors: Becky H Lee Giulia Tebaldi Suzanne M Pritchard Anthony V Nicola Source Type: research

E3 ligase RNF5 inhibits type I interferon response in herpes simplex virus keratitis through the STING/IRF3 signaling pathway
In this study, we found that the expression of RNF5 was elevated in corneal tissues and corneal epithelial cells after infection with HSV-1. Immunofluorescence staining confirmed that RNF5 was mainly expressed in the corneal epithelial layer. We silenced and overexpressed RNF5 expression in corneal epithelial cells and then inoculated them with HSV-1. We found that the expressions of STING, p-IRF3, p-TBK1, and IFN-β mRNA increased after RNF5 silencing. The opposite results were obtained after RNF5 overexpression. We also used siRNA to silence RNF5 in the mouse cornea and then established the HSK model. Compared with the s...
Source: Herpes - August 22, 2022 Category: Infectious Diseases Authors: Zhi Liu Likun Xia Source Type: research

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