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Specialty: Infectious Diseases
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Total 139 results found since Jan 2013.
An aging-susceptible circadian rhythm controls cutaneous antiviral immunity
JCI Insight. 2023 Sep 19:e171548. doi: 10.1172/jci.insight.171548. Online ahead of print.ABSTRACTAged skin is prone to viral infections, but the mechanisms responsible for this immunosenescent immune risk are unclear. We observed that aged murine and human skin expressed reduced antiviral proteins (AVPs) and circadian regulators including Bmal1 and Clock. Bmal1 and Clock were found to control rhythmic AVP expression in skin and such circadian-control of AVPs was diminished by disruption of immune cell interleukin 27 signaling and deletion of Bmal1/Clock genes in mouse skins, as well as siRNA-mediated knockdown of CLOCK in ...
Source: Herpes - September 19, 2023 Category: Infectious Diseases Authors: Stephen Kirchner Vivian Lei Paul T Kim Meera Patel Jessica L Shannon David Corcoran Dalton Hughes Diana K Waters Kafui Dzirasa Detlev Erdmann J örn Coers Amanda S MacLeod Jennifer Y Zhang Source Type: research
AMPK protects endothelial cells against HSV-1 replication via inhibition of mTORC1 and ACC1
Microbiol Spectr. 2023 Sep 13:e0041723. doi: 10.1128/spectrum.00417-23. Online ahead of print.ABSTRACTHerpes simplex virus type 1 (HSV-1) is a widespread contagious pathogen, mostly causing mild symptoms on the mucosal entry side. However, systemic distribution, in particular upon reactivation of the virus in immunocompromised patients, may trigger an innate immune response and induce damage of organs. In these conditions, HSV-1 may infect vascular endothelial cells, but little is known about the regulation of HSV-1 replication and possible defense mechanisms in these cells. The current study addresses the question of whet...
Source: Herpes - September 13, 2023 Category: Infectious Diseases Authors: Heena Doshi Katrin Spengler Amod Godbole Yi Sing Gee Jonathan Baell Jonathan S Oakhill Andreas Henke Regine Heller Source Type: research
Mycobacterium tuberculosis Rv2653 protein promotes inflammation response by enhancing glycolysis
Jpn J Infect Dis. 2023 Jul 31. doi: 10.7883/yoken.JJID.2022.647. Online ahead of print.ABSTRACTMycobacterium tuberculosis (M.tb) infection caused communicable disease tuberculosis (TB) is a major cause of ill health and one of the leading causes of death worldwide. Protein encoded by region of deletion (RD) of M.tb mediated the pathogenic properties of M.tb through inducing inflammation response or disrupting host cell metabolism. We cloned and purified Rv2653 protein from RD13 to explore its regulatory effect on host macrophages. We found Rv2653 protein promoted the glycolysis level and upregulated the expression of glyco...
Source: Japanese Journal of Infectious Diseases - July 30, 2023 Category: Infectious Diseases Authors: Yaman Du Rui Zheng Hongli Yin Li Ma Jingfang Li Yun Chen Xi Zhang Pengzuo Tao Lili Gao Li Yang Liang He Source Type: research
