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Specialty: Infectious Diseases
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Total 139 results found since Jan 2013.
Mycobacterium tuberculosis Rv2653 protein promotes inflammation response by enhancing glycolysis
Jpn J Infect Dis. 2023 Jul 31. doi: 10.7883/yoken.JJID.2022.647. Online ahead of print.ABSTRACTMycobacterium tuberculosis (M.tb) infection caused communicable disease tuberculosis (TB) is a major cause of ill health and one of the leading causes of death worldwide. Protein encoded by region of deletion (RD) of M.tb mediated the pathogenic properties of M.tb through inducing inflammation response or disrupting host cell metabolism. We cloned and purified Rv2653 protein from RD13 to explore its regulatory effect on host macrophages. We found Rv2653 protein promoted the glycolysis level and upregulated the expression of glyco...
Source: Japanese Journal of Infectious Diseases - July 30, 2023 Category: Infectious Diseases Authors: Yaman Du Rui Zheng Hongli Yin Li Ma Jingfang Li Yun Chen Xi Zhang Pengzuo Tao Lili Gao Li Yang Liang He Source Type: research
ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells
Viruses. 2023 Jun 27;15(7):1457. doi: 10.3390/v15071457.ABSTRACTThe strong contribution of RAS-related protein 1b (Rap1b) to cytoskeleton remodeling determines intracellular and extracellular physiological activities, including the successful infection of viruses in permissive cells, but its role in the HSV-1 life cycle is still unclear. Here, we demonstrated that the HSV-1 immediate early (IE) gene ICP4 inhibits protein kinase A (PKA) phosphorylation to induce Rap1b-activation-mediated viral infection. Rap1b activation and membrane enrichment begin at the early stage of HSV-1 infection and remain active during the prolife...
Source: Herpes - July 29, 2023 Category: Infectious Diseases Authors: Beibei Zhang Juntao Ding Zhenghai Ma Source Type: research
Herpes simplex virus type I glycoprotein L evades host antiviral innate immunity by abrogating the nuclear translocation of phosphorylated NF- κB sub-unit p65
Front Microbiol. 2023 May 9;14:1178249. doi: 10.3389/fmicb.2023.1178249. eCollection 2023.ABSTRACTNuclear factor (NF)-κB plays an important role in the innate immune response by inducing antiviral genes' expression. However, the herpes simplex virus 1 (HSV-1) virus has developed multiple ways to interfere with NF-κB activity to escape the host antiviral response. Here, we found that HSV-1 envelope glycoprotein L(gL) markedly inhibits interferon (IFN) production and its downstream antiviral genes. Our results showed that ectopic expression of gL inhibited IFN-β promoter activation, and decreased IFN-β production, the ex...
Source: Herpes - May 25, 2023 Category: Infectious Diseases Authors: Zhaolong Li Zhihua Feng Zhou Fang Jianghua Chen Wengzhi Chen Wangwang Liang Qi Chen Source Type: research
An Aging-Susceptible Circadian Rhythm Controls Cutaneous Antiviral Immunity
bioRxiv. 2023 Apr 18:2023.04.14.536934. doi: 10.1101/2023.04.14.536934. Preprint.ABSTRACTAged skin is prone to viral infections, but the mechanisms responsible for this immunosenescent immune risk are unclear. We observed that aged murine and human skin expressed reduced antiviral proteins (AVPs) and circadian regulators including Bmal1 and Clock. Bmal1 and Clock were found to control rhythmic AVP expression in skin and such circadian-control of AVPs was diminished by disruption of immune cell interleukin 27 signaling and deletion of Bmal1/Clock genes in mouse skins, as well as siRNA-mediated knockdown of CLOCK in human pr...
Source: Herpes - May 3, 2023 Category: Infectious Diseases Authors: Stephen Kirchner Vivian Lei Paul Kim Meera Patel Jessica Shannon David Corcoran Dalton Hughes Diana Waters Kafui Dzirasa Detlev Erdmann J örn Coers Amanda MacLeod Jennifer Y Zhang Source Type: research
