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Cyclosporin a inhibits the propagation of influenza virus by interfering with a late event in the virus life cycle.
Abstract Influenza is a global public health problem that causes a serious respiratory disease. Influenza virus frequently undergoes amino acid substitutions, which result in the emergence of drug-resistant viruses. To control influenza viruses that are resistant to currently available drugs, it is essential to develop new antiviral drugs with a novel molecular target. Here, we report that cyclosporin A (CsA) inhibits the propagation of influenza virus in A549 cells by interfering with a late event in the virus life cycle. CsA did not affect adsorption, internalization, viral RNA replication, or synthesis of viral...
Source: Japanese Journal of Infectious Diseases - July 29, 2013 Category: Infectious Diseases Authors: Hamamoto I, Harazaki K, Inase N, Takaku H, Tashiro M, Yamamoto N Tags: Jpn J Infect Dis Source Type: research

Role and application of RNA interference in replication of influenza viruses.
Abstract RNA interference (RNAi) is a naturally occurring endogenous biological post-transcriptional cellular mechanism that regulates RNA expression. Small interfering RNAs (siRNAs), mediators of RNAi, are short (19-26nt), double-stranded RNA duplexes that inhibit gene expression by inducing sequence-specific degradation of homologous messenger RNA (mRNA). Influenza virus infection is a major public health problem, causing hundreds of thousands of deaths worldwide each year. RNAi have provided a means to performing genome-wide screens to determine and validate host cell genes that may be required for influenza...
Source: Acta Virologica - May 25, 2013 Category: Infectious Diseases Authors: Betáková T, Svančarová P Tags: Acta Virol Source Type: research

Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog
Conclusion: DSF reactivates latent HIV-1 expression via the Akt signaling pathway through depletion of PTEN.
Source: AIDS - January 14, 2013 Category: Infectious Diseases Tags: Fast Track Source Type: research

HIV-1 trans-activator protein dysregulates IFN-γ signaling and contributes to the suppression of autophagy induction
Conclusion: HIV-1 Tat suppressed the induction of autophagy-associated genes and inhibited the formation of autophagosomes. Perturbation of such cellular processes by HIV-1 would impair the effective containment of invading pathogens, thereby providing a favorable environment for opportunistic microbes in HIV-infected individuals.
Source: AIDS - January 2, 2011 Category: Infectious Diseases Tags: Basic Science Source Type: research

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