Cyclosporin a inhibits the propagation of influenza virus by interfering with a late event in the virus life cycle.

Cyclosporin a inhibits the propagation of influenza virus by interfering with a late event in the virus life cycle. Jpn J Infect Dis. 2013;66(4):276-83 Authors: Hamamoto I, Harazaki K, Inase N, Takaku H, Tashiro M, Yamamoto N Abstract Influenza is a global public health problem that causes a serious respiratory disease. Influenza virus frequently undergoes amino acid substitutions, which result in the emergence of drug-resistant viruses. To control influenza viruses that are resistant to currently available drugs, it is essential to develop new antiviral drugs with a novel molecular target. Here, we report that cyclosporin A (CsA) inhibits the propagation of influenza virus in A549 cells by interfering with a late event in the virus life cycle. CsA did not affect adsorption, internalization, viral RNA replication, or synthesis of viral proteins in A549 cells, but inhibited the step(s) after viral protein synthesis, such as assembly or budding. In addition, siRNA-mediated knockdown of the expression of the major CsA targets, namely cyclophilin A (CypA), cyclophilin B (CypB), and P-glycoprotein (Pgp), did not inhibit influenza virus propagation. These results suggest that CsA inhibits virus propagation by mechanism(s) independent of the inhibition of the function of CypA, CypB, and Pgp. CsA may target an unknown molecule that works as a positive regulator in the propagation of influenza virus. Our findings would contribute to the development of a novel anti-inf...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research

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Due to an unfortunate oversight the acknowledgements has been omitted.
Source: Journal of Public Health Policy - Category: Health Management Source Type: research
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Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
by Amy Reese, PharmD, MA. Tamiflu (oseltamivir) is a neuraminidase inhibitor which decreases the viral spread of Influenza A and B. It was a revolutionary drug when it was approved by the FDA in December 2000 because it was indicated to reduce the duration and severity of both influenza viruses. It was also proven to prevent a patient from being infected with either influenza virus. The only stipulation with the medication was that its efficacy was only shown within the first 48 hours of influenza symptoms.…
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Decision making Featured Posts Health Care Health Policy & Insurance Pharmaceuticals Source Type: blogs
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
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Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
AbstractTo investigate the effects of short-term discontinuation of methotrexate (MTX) on disease activity in patients with rheumatoid arthritis (RA) taking a stable dose of MTX. A post-hoc analysis of two randomized controlled trials was used to investigate the effects of temporary MTX discontinuation (for 2  weeks or 4 weeks) on responses to seasonal influenza vaccination. The impact of MTX discontinuation on the RA disease activity score (DAS28) and RA flare rate during discontinuation and after reintroduction was examined. The DAS28 increased during the 4-week MTX discontinuation period, before ret urning to ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
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