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Specialty: Geriatrics

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Total 31 results found since Jan 2013.

Insulin-Like Growth Factor I Prevents Cellular Aging via Activation of Mitophagy.
Authors: Hou X, Li Z, Higashi Y, Delafontaine P, Sukhanov S Abstract Mitochondrial dysfunction is a hallmark of cellular aging. Mitophagy is a critical mitochondrial quality control mechanism that removes dysfunctional mitochondria and contributes to cell survival. Insulin-like growth factor 1 (IGF-1) promotes survival of smooth muscle cells (SMCs), but its potential effect on cellular aging is unknown yet. We found that IGF-1 decreased cell senescence, prevented DNA telomere shortening, increased mitochondrial membrane potential, activated cytochrome C oxidase, and reduced mitochondrial DNA damage in long-term cul...
Source: Journal of Aging Research - August 19, 2020 Category: Geriatrics Tags: J Aging Res Source Type: research

Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/SIRT1-FOXA3-Beclin1 pathway.
This study confirmed that glucose restriction can enhance autophagy, inhibit senescence, and enhance proliferation of HUVECs through the AMPK/SIRT1-FOXA3-Beclin1 pathway. PMID: 32768436 [PubMed - as supplied by publisher]
Source: Experimental Gerontology - August 4, 2020 Category: Geriatrics Authors: Liu Q, Li H, Wang J, Zhong L, Chen X, Zhang R, Wang H Tags: Exp Gerontol Source Type: research

17 β-estradiol inhibits H2O2-induced senescence in HUVEC cells through upregulating SIRT3 expression and promoting autophagy.
In this study, we examined the roles of SIRT3 in 17β-E2-induced autophagy and 17β-E2-mediated inhibition of hydrogen peroxide (H2O2)-induced senescence in Human umbilical vein endothelial cells (HUVEC). Cellular senescence was measured by immunoblot analysis with antibodies against phosphorylated Rb and senescence-associated β-galactosidase staining. Immunoblot analysis with antibodies against LC3 and p62 was performed to determine autophagy flux. Our findings show that 17β-E2 activates SIRT3 promoter and upregulates SIRT3 gene expression in HUVEC cells. siRNA-mediated silencing of SIRT3 gene expression inhibits 17β-E...
Source: Biogerontology - March 13, 2020 Category: Geriatrics Authors: Xiang X, Huang J, Song S, Wang Y, Zeng Y, Wu S, Ruan Y Tags: Biogerontology Source Type: research

Genome-wide profiling of adult human papillary and reticular fibroblasts identifies ACAN, Col XI α1, and PSG1 as general biomarkers of dermis ageing, and KANK4 as an exemplary effector of papillary fibroblast ageing, related to contractility
Publication date: Available online 18 June 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Valérie Haydont, Véronique Neiveyans, Hélène Zucchi, Nicolas O. Fortunel, Daniel AsselineauAbstractDeciphering the characteristics of dermal fibroblasts is critical to further understand skin ageing. We have conducted a genome-wide transcriptomic characterization of papillary (Fp) and reticular (Fr) fibroblasts extracted from human skin samples corresponding to younger and older adult ages. From this screen, biomarkers suitable for the assessment of chronological ageing were identified, and extrapolated to the context ...
Source: Mechanisms of Ageing and Development - July 10, 2018 Category: Geriatrics Source Type: research

OLR1 scavenger receptor knockdown affects mitotic gene expression but is dispensable for oxidized phospholipid- mediated stress signaling in SZ 95 sebocytes
Publication date: Available online 2 November 2017 Source:Mechanisms of Ageing and Development Author(s): Ionela-Mariana Nagelreiter, Masomeh Parvardeh, Marie-Sophie Narzt, Lucian Beer, Christopher Kremslehner, Ximena Maria Muresan, Johannes Grillari, Christos C. Zouboulis, Erwin Tschachler, Florian Gruber Phospholipid oxidation products (OxPL) are versatile stress signaling mediators in the skin. These lipid signaling molecules can be generated non-enzymatically or enzymatically by ultraviolet light, the major extrinsic skin aging factor. OxPL regulate cytoprotective, immunological and metabolic adaptation of the skin to...
Source: Mechanisms of Ageing and Development - December 11, 2017 Category: Geriatrics Source Type: research

Role of Prion protein in premature senescence of human fibroblasts
Publication date: Available online 8 August 2017 Source:Mechanisms of Ageing and Development Author(s): Emmanuelle Boilan, Virginie Winant, Elise Dumortier, Benaissa ElMoualij, Pascale Quatresooz, Heinz D. Osiewacz, Florence Debacq-Chainiaux, Olivier Toussaint Prion protein (PrP) is essentially known for its capacity to induce neurodegenerative prion diseases in mammals caused by a conformational change in its normal cellular isoform (PrPC) into an infectious and disease-associated misfolded form, called scrapie isoform (PrPSc). Although its sequence is highly conserved, less information is available on its physiological ...
Source: Mechanisms of Ageing and Development - August 9, 2017 Category: Geriatrics Source Type: research

Testosterone delays vascular smooth muscle cell senescence and inhibits collagen synthesis via the Gas6/Axl signaling pathway
Abstract Testosterone deficiency is associated with a higher incidence of cardiovascular diseases in men. However, its effect on cell senescence, which plays a causal role in vascular aging, remains unclear. Here, we tested the hypothesis that testosterone alleviated vascular smooth muscle cell (VSMC) senescence and collagen synthesis via growth arrest-specific protein 6 (Gas6)/Axl- and Akt/FoxO1a-dependent pathways. Testosterone significantly ameliorated angiotensin II-induced VSMC senescence and collagen overexpression. In addition, testosterone inhibited angiotensin II-induced matrix metalloproteinase-2 (MMP-2...
Source: AGE - May 19, 2016 Category: Geriatrics Source Type: research

p15(INK4b) regulates cell cycle signaling in hippocampal astrocytes of aged rats.
CONCLUSIONS: These observations suggest p15(INK4b) is expressed at a steady level in neonatal and adult rat hippocampal astrocytes with no effect on cell cycle regulation. Importantly, aged astrocyte cell cycle regulation was significantly affected by high expression levels of p15(INK4b) suggesting a role for p15(INK4b) in cell cycle regulation when it is expressed at high but not moderate or low levels in hippocampal astrocytes. PMID: 26526028 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - November 2, 2015 Category: Geriatrics Authors: Wang F, Zhang L Tags: Aging Clin Exp Res Source Type: research

Up-regulation of steroid biosynthesis by retinoid signaling: Implications for aging
We reported that regulation of retinoid, especially atRA and 9-cis RA, responsive StAR transcription is largely mediated by an LXR-RXR/RAR heterodimeric motif in the mouse StAR promoter. Herein we demonstrate that retinoids are capable of enhancing StAR protein, P-StAR, and steroid production, in granulosa, adrenocortical, glial, and epidermal cells. Whereas transient expression of RARα and RXRα enhanced 9-cis RA-treated StAR gene transcription, silencing of RXRα with siRNA, decreased StAR and steroid levels. An oligonucleotide probe encompassing an LXR-RXR/RAR motif bound to adrenocortical and epidermal keratinocyte NE...
Source: Mechanisms of Ageing and Development - August 22, 2015 Category: Geriatrics Source Type: research

Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells
The heat shock 70 family protein, mortalin, has pancytoplasmic distribution pattern in normal and perinuclear in cancer human cells. Cancer cells when induced to senesce by either chemicals or stress showed shift in mortalin staining pattern from perinuclear to pancytoplasmic type. Using such shift in mortalin staining as a reporter, we screened human shRNA library and identified nine senescence-inducing siRNA candidates. An independent Comparative Genomic Hybridization analysis of 35 breast cancer cell lines revealed that five (NBS1, BRCA1, TIN2, MRE11A, and KPNA2) of the nine genes located on chromosome regions identifie...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 9, 2015 Category: Geriatrics Authors: Gao, R., Singh, R., Kaul, Z., Kaul, S. C., Wadhwa, R. Tags: Original Article Source Type: research

Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis.
In this study, we show for the first time that the protein level of plasminogen activator inhibitor 1 (PAI-1), a protease inhibitor which plays an essential role in the control of fibrinolysis, was significantly increased with age in mouse lung homogenate and lung fibroblasts. Upon bleomycin challenge, old mice experienced augmented PAI-1 induction and lung fibrosis as compared to young mice. Most interestingly, we show that fewer (myo)fibroblasts underwent apoptosis and more (myo)fibroblasts with increased level of PAI-1 accumulated in the lung of old than in young mice after bleomycin challenge. In vitro studies further ...
Source: Experimental Gerontology - November 28, 2014 Category: Geriatrics Authors: Huang WT, Akhter H, Jiang C, MacEwen M, Ding Q, Antony V, Thannickal VJ, Liu RM Tags: Exp Gerontol Source Type: research

p16INK4A mediates age-related changes in mesenchymal stem cells derived from human dental pulp through the DNA damage and stress response
Publication date: November–December 2014 Source:Mechanisms of Ageing and Development, Volumes 141–142 Author(s): Xingmei Feng , Jing Xing , Guijuan Feng , Dan Huang , Xiaohui Lu , Suzhe Liu , Wei Tan , Liren Li , Zhifeng Gu Mesenchymal stem cells derived from human dental pulp (DP-MSCs) are characterized by self-renewal and multi-lineage differentiation, which play important roles in regenerative medicine. Autologous transfers, as non-immunogenic, constitute the safest approach in cellular transplantations. However, their use may be limited by age-related changes. In the study, we compared DP-MSCs isolated from human...
Source: Mechanisms of Ageing and Development - November 3, 2014 Category: Geriatrics Source Type: research

Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats.
Abstract Adipogenesis and lipid accumulation during aging have a great impact on the aging process and the pathogenesis of chronic, age-related diseases. However, little is known about the age-related molecular changes in lipid accumulation and the mechanisms underlying them. Here, using 5-month- and 25-month-old rats (young and old, respectively), we found that epididymal fat is the only tissue to accumulate during aging. By testing tissues rich with mitochondria in old and young animals, we found that the old animals had elevated levels of triglycerides in their muscle, heart and liver tissues but not in their k...
Source: Experimental Gerontology - February 8, 2014 Category: Geriatrics Authors: Zhao L, Zou X, Feng Z, Luo C, Liu J, Li H, Chang L, Wang H, Li Y, Long J, Gao F, Liu J Tags: Exp Gerontol Source Type: research