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Specialty: Stem Cells
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Total 81 results found since Jan 2013.
Autocrine Action of Thrombospondin‐2 Determines the Chondrogenic Differentiation Potential and Suppresses Hypertrophic Maturation of Human Umbilical Cord Blood‐derived Mesenchymal Stem Cells
This article is protected by copyright. All rights reserved.
Source: Stem Cells - July 31, 2015 Category: Stem Cells Authors: Sang Young Jeong, Jueun Ha, Miyoung Lee, Hye Jin Jin, Dong Hyun Kim, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Jae‐Sung Kim, Byung‐Gyu Kim, Jeong Ho Chang, Dong‐Hyung Cho, Hong Bae Jeon Tags: Regenerative Medicine Source Type: research
Ex vivo immunosuppressive effects of mesenchymal stem cells on Crohn’s disease mucosal T cells are largely dependent on indoleamine 2,3-dioxygenase activity and cell-cell contact
Conclusion:
MSCs exert potent immunomodulant effects on antigen-specific T cells in CD through a complex paracrine and cell-cell contact-mediated action, which may be exploited for widespread therapeutic use.
Source: Stem Cell Research and Therapy - July 24, 2015 Category: Stem Cells Authors: Rachele CiccocioppoGiuseppina CangemiPeter KruzliakAlessandra GalliaElena BettiCarla BadulliMiryam MartinettiMarila CervioAlessandro PecciValeria BozziPaolo DionigiLivia VisaiAntonella GurradoCostanza AlvisiCristina PiconeManuela MontiMaria BernardoPaolo Source Type: research
Geminin Is Essential to Prevent DNA Re‐Replication‐Dependent Apoptosis in Pluripotent Cells, but not in Differentiated Cells
Abstract
Geminin is a dual‐function protein unique to multicellular animals with roles in modulating gene expression and preventing DNA re‐replication. Here, we show that geminin is essential at the beginning of mammalian development to prevent DNA re‐replication in pluripotent cells, exemplified by embryonic stem cells, as they undergo self‐renewal and differentiation. Embryonic stem cells, embryonic fibroblasts, and immortalized fibroblasts were characterized before and after geminin was depleted either by gene ablation or siRNA. Depletion of geminin under conditions that promote either self‐renewal or differen...
Source: Stem Cells - July 16, 2015 Category: Stem Cells Authors: Yi‐Yuan Huang, Kotaro J. Kaneko, Haiyan Pan, Melvin L. DePamphilis Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research
Geminin Is Essential To Prevent DNA Re‐Replication Dependent Apoptosis In Pluripotent Cells, But Not In Differentiated Cells
This article is protected by copyright. All rights reserved.
Source: Stem Cells - July 1, 2015 Category: Stem Cells Authors: Yi‐Yuan Huang, Kotaro J. Kaneko, Haiyan Pan, Melvin L. DePamphilis Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research
Cholesterol-derived glucocorticoids control early fate specification in embryonic stem cells
Publication date: Available online 13 May 2015 Source:Stem Cell Research Author(s): Joaquim Cabral-Teixeira , Almudena Martinez-Fernandez , Wenqing Cai , Andre Terzic , Mark Mercola , Erik Willems Aside from its role in cell membrane integrity, cholesterol is a key component in steroid hormone production. The vital functions of steroid hormones such as estrogen, testosterone, glucocorticoids (Gcrts) and mineralocorticoids (Mnrts) in perinatal and adult life are well understood; however, their role during early embryonic development remains largely unexplored. Here we show that siRNA-mediated perturbation of steroid hormo...
Source: Stem Cell Research - May 15, 2015 Category: Stem Cells Source Type: research
High‐Throughput Differentiation and Screening of a Library of Mutant Stem Cell Clones Defines New Host‐Based Genes Involved in Rabies Virus Infection
Abstract
We used a genomic library of mutant murine embryonic stem cells (ESCs) and report the methodology required to simultaneously culture, differentiate, and screen more than 3,200 heterozygous mutant clones to identify host‐based genes involved in both sensitivity and resistance to rabies virus infection. Established neuronal differentiation protocols were miniaturized such that many clones could be handled simultaneously, and molecular markers were used to show that the resultant cultures were pan‐neuronal. Next, we used a green fluorescent protein (GFP) labeled rabies virus to develop, validate, and implement on...
Source: Stem Cells - May 12, 2015 Category: Stem Cells Authors: Deeann Wallis, Kimberly Loesch, Stacy Galaviz, Qingan Sun, Michael DeJesus, Thomas Ioerger, James C. Sacchettini Tags: Stem Cell Technology: Epigenetics, Genomics, Proteomics and Metabonomics Source Type: research
Macrophage migration inhibitory factor confers resistance to senescence through CD74-dependent AMPK-FOXO3a signaling in mesenchymal stem cells
Conclusions:
MIF can rejuvenate MSCs from a state of age-induced senescence by interacting with CD74 and subsequently activating AMPK-FOXO3a signaling pathways. Pretreatment of MSCs with MIF may have important therapeutic implications in restoration or rejuvenation of endogenous bone marrow-MSCs in aged individuals.
Source: Stem Cell Research and Therapy - April 22, 2015 Category: Stem Cells Authors: Wenzheng XiaFengyun ZhangCongying XieMiaomiao JiangMeng Hou Source Type: research
Molecular differences between stromal cell populations from deciduous and permanent human teeth
Conclusions:
Taken together, our data suggest that deciduous pulp cells are more robust in self- renewal and proliferation, whereas adult dental pulp cells are more capable of signaling and matrix synthesis.
Source: Stem Cell Research and Therapy - April 18, 2015 Category: Stem Cells Authors: Nina KaukuaMo ChenPaolo GuarnieriMarkus DahlMei LimTülay Yucel-LindbergErik SundströmIgor AdameykoJeremy MaoKaj Fried Source Type: research
Systematic implantation of dedifferentiated fat cells ameliorated monoclonal antibody 1-22-3-induced glomerulonephritis by immunosuppression with increases in TNF-stimulated gene 6
Conclusion:
Systematic implantation of DFAT cells effectively ameliorated mAb 1-22-3-induced glomerulonephritis through immunosuppressive effects accompanied by the suppression of macrophage infiltration and expression of IL-6, IL-10 and IL12β, and increased production of serum and renal TSG-6 that improved the mAb 1-22-3-induced renal degeneration by the immunosuppressive effects of TSG-6. Thus DFAT cells will be suitable cell source for the treatment of immunological progressive renal diseases.
Source: Stem Cell Research and Therapy - April 16, 2015 Category: Stem Cells Authors: Takashi MaruyamaNoboru FukudaTaro MatsumotoKoichiro KanoMorito EndoMinako KazamaTomohiko KazamaJin IkedaHiroyuki MatsudaTakahiro UenoMasanori AbeKazuyoshi OkadaMasayoshi SomaKoichi MatsumotoHiroshi Kawachi Source Type: research
Novel Pathway for Hypoxia‐Induced Proliferation and Migration in Human Mesenchymal Stem Cells: Involvement of HIF‐1α, FASN, and mTORC1
In conclusion, the HIF‐1α/FASN/mTORC1 axis is a key pathway linking hypoxia‐induced lipid metabolism with proliferation and migration in UCB‐hMSCs. This article is protected by copyright. All rights reserved.
Source: Stem Cells - March 31, 2015 Category: Stem Cells Authors: Hyun Jik Lee, Jung Min Ryu, Young Hyun Jung, Sang Yub Oh, Sei‐Jung Lee, Ho Jae Han Tags: Stem Cell Technology: Epigenetics, Genomics, Proteomics and Metabonomi Source Type: research
High throughput differentiation and screening of a library of mutant stem cell clones defines new host‐based genes involved in rabies virus infection
This article is protected by copyright. All rights reserved.
Source: Stem Cells - March 5, 2015 Category: Stem Cells Authors: Deeann Wallis, Kimberly Loesch, Stacy Galaviz, Qingan Sun, Michael DeJesus, Thomas Ioerger, James C. Sacchettini Tags: Stem Cell Technology: Epigenetics, Genomics, Proteomics and Metabonomics Source Type: research
Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF‐1R Onto the Primary Cilium Associated with Cilia Elongation
This study tested the hypothesis that changes in primary cilia structure are required for stem cell differentiation. hMSCs expressed primary cilia which were labelled with acetylated alpha tubulin and visualized by confocal microscopy. Chemically induced differentiation resulted in lineage specific changes in cilia length and prevalence independent of cell cycle. In particular adipogenic differentiation resulted in cilia elongation associated with the presence of dexamethasone, whilst insulin had an inhibitory effect on cilia length. Over a seven day time course adipogenic differentiation media resulted in cilia elongation...
Source: Stem Cells - February 18, 2015 Category: Stem Cells Authors: Melis T. Dalbay, Stephen D. Thorpe, John T. Connelly, J. Paul Chapple, Martin M. Knight Tags: Tissue‐specific stem cells Source Type: research
Focal Adhesion Kinase and Wnt Signaling Regulate Human Ductal Carcinoma In Situ Stem Cell Activity and Response to Radiotherapy
Abstract
Cancer stem cells (CSCs) can avoid or efficiently repair DNA damage from radio and chemotherapy, which suggests they play a role in disease recurrence. Twenty percentage of patients treated with surgery and radiotherapy for ductal carcinoma in situ (DCIS) of the breast recur and our previous data show that high grade DCIS have increased numbers of CSCs. Here, we investigate the role of focal adhesion kinase (FAK) and Wnt pathways in DCIS stem cells and their capacity to survive irradiation. Using DCIS cell lines and patient samples, we demonstrate that CSC‐enriched populations are relatively radioresistant and p...
Source: Stem Cells - January 22, 2015 Category: Stem Cells Authors: Kathryn E. Williams, Nigel J. Bundred, Göran Landberg, Robert B. Clarke, Gillian Farnie Tags: Cancer Stem Cells Source Type: research
Loss of non-coding RNA expression from the DLK1-DIO3 imprinted locus correlates with reduced neural differentiation potential in human embryonic stem cell lines
Conclusions:
Repression of ncRNAs derived from the DLK1-DIO3 imprinted locus is associated with reduced neural lineage differentiation potential in hESCs.
Source: Stem Cell Research and Therapy - January 5, 2015 Category: Stem Cells Authors: Chu-Fan MoFang-Chun WuKang-Yu TaiWei-Chun ChangKai-Wei ChangHung-Chi KuoHong-Nerng HoHsin-Fu ChenShau-Ping Lin Source Type: research
Selective interference targeting of lnk in umbilical cord‐derived late endothelial progenitor cells improves vascular repair, following hindlimb ischemic injury, via regulation of JAK2/STAT3 signaling
This article is protected by copyright. All rights reserved.
Source: Stem Cells - December 23, 2014 Category: Stem Cells Authors: Sang Hun Lee, Kyeung Bin Lee, Jun Hee Lee, Songhwa Kang, Hwi Gon Kim, Takayuki Asahara, Sang Mo Kwon Tags: Regenerative Medicine Source Type: research
