• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Inflammatory Cytokine Interleukin-6 (IL-6) Promotes the Proangiogenic Ability of Adipose Stem Cells from Obese Subjects < em > via < /em > the IL-6 Signaling Pathway
CONCLUSION: The finding suggests that inflammatory cytokine interleukin-6 (IL-6) promotes the proangiogenic ability of obADSCs via the IL-6 signaling pathway.PMID:36883256 | DOI:10.2174/1574888X17666220429103935
Source: Current Stem Cell Research and Therapy - March 8, 2023 Category: Stem Cells Authors: Yuanyuan Zhang Pengju Lv Yalong Li Yonghui Zhang Chaofei Cheng Hongbo Hao Han Yue Source Type: research

YBX1 promotes MSC osteogenic differentiation by activating the PI3K/AKT pathway
CONCLUSION: Our study provides a new target and theoretical basis for the treatment of bone diseases.PMID:35929633 | DOI:10.2174/1574888X17666220805143833
Source: Current Stem Cell Research and Therapy - August 5, 2022 Category: Stem Cells Authors: Jiayu Chen Zhanliang Liu Huicheng Zhang Yongqian Yang Huangxiang Zeng Rongwei Zhong Shangdao Lai Hongxing Liao Source Type: research

In  vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
Cell Stem Cell. 2022 Jan 24:S1934-5909(22)00001-7. doi: 10.1016/j.stem.2022.01.001. Online ahead of print.ABSTRACTIdentifying new pathways that regulate mammalian regeneration is challenging due to the paucity of in vivo screening approaches. We employed pooled CRISPR knockout and activation screening in the regenerating liver to evaluate 165 chromatin regulatory proteins. Both screens identified the imitation-SWI chromatin remodeling components Baz2a and Baz2b, not previously implicated in regeneration. In vivo sgRNA, siRNA, and knockout strategies against either paralog confirmed increased regeneration. Distinct BAZ2-spe...
Source: Cell Stem Cell - January 29, 2022 Category: Stem Cells Authors: Yuemeng Jia Lin Li Yu-Hsuan Lin Purva Gopal Shunli Shen Kejin Zhou Xueliang Yu Tripti Sharma Yu Zhang Daniel J Siegwart Joseph M Ready Hao Zhu Source Type: research

Increased Lipogenesis Is Critical for Self ‐Renewal and Growth of Breast Cancer Stem Cells: Impact of Omega‐3 Fatty Acids
Breast cancer stem cells (CSC) have a distinct fatty acid profile due to the aberrant expressions of lipogenic enzymes (eg, FAS, SCD1, and FADS1/2), which are highly involved in sustaining their self-renewal, and proliferative capabilities. Omega-3 PUFA can effectively suppress the self-renewal and growth of breast CSC by downregulation of the lipogenic enzymes, especially SCD1. AbstractAberrant lipid metabolism has recently been recognized as a new hallmark of malignancy, but the characteristics of fatty acid metabolism in breast cancer stem cells (BCSC) and potential interventions targeting this pathway remain to be addr...
Source: Stem Cells - September 6, 2021 Category: Stem Cells Authors: Haiqing Luo, Chih ‐Yu Chen, Xiangyong Li, Xin Zhang, Chien‐Wen Su, Yinhua Liu, Tinglan Cao, Lei Hao, Meng Wang, Jing Xuan Kang Tags: Cancer Stem Cells Source Type: research

High ‐mobility group AT‐Hook 1 mediates the role of nuclear factor I/X in osteogenic differentiation through activating canonical Wnt signaling
This study suggests that HMGA1 plays a role in osteoblast commitment and mediates the function of NFIX through transcriptionally activating canonical Wnt signaling.© AlphaMed Press 2021Significance StatementBone homeostasis depends largely on the number and function of osteoblasts. Osteoblasts and adipocytes are both derived from bone marrow mesenchymal stem cells, and a competitive relationship exists between adipogenesis and osteogenesis. We have identified a novel nuclear factor I/X (NFIX)-high-mobility group AT-Hook 1 (HMGA1)-wingless-type MMTV integration site (Wnt)/ β-catenin regulatory axis that governs the cell f...
Source: Stem Cells - May 24, 2021 Category: Stem Cells Authors: Xiaowen Wu, Xiaochen Wang, Liying Shan, Jie Zhou, Xin Zhang, Endong Zhu, Hairui Yuan, Baoli Wang Tags: Tissue ‐Specific Stem Cells Source Type: research

Pages: 1  2  3  4  5  6