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Canonical Notch signaling is required for bone morphogenetic protein ‐mediated human osteoblast differentiation
Bone morphogenetic protein (BMP) stimulation of bone ‐marrow‐derived human mesenchymal progenitor cells (hMSCs) increases Notch proteins via increased Notch ligand Jagged1 expression. Canonical Notch signaling is required for BMP‐induced ALPL expression and osteoblastic commitment of hMSCs. Both BMP‐induced osteoblastogenesis and Notch‐induc ed osteoblastogenesis require Runx2. AbstractOsteoblast differentiation of bone ‐marrow‐derived human mesenchymal stem cells (hMSC) can be induced by stimulation with canonical Notch ligand, Jagged1, or bone morphogenetic proteins (BMPs). However, it remains elusive how t...
Source: Stem Cells - June 23, 2020 Category: Stem Cells Authors: Yadav Wagley, Alessandra Chesi, Parker K. Acevedo, Sumei Lu, Andrew D. Wells, Matthew E. Johnson, Struan F. A. Grant, Kurt D. Hankenson Tags: Tissue ‐Specific Stem Cells Source Type: research

Canonical Notch Signaling is Required for Bone Morphogenetic Protein ‐mediated Human Osteoblast Differentiation
BMP stimulation of bone ‐marrow derived human mesenchymal progenitor cells (hMSCs) increases Notch proteins via increased Notch ligand Jagged1 expression. Canonical Notch signaling is required for BMPinduced ALPL expression and osteoblastic commitment of hMSCs. Both BMP‐induced osteoblastogenesis and Notch‐induced os teoblastogenesis require Runx2. AbstractOsteoblast differentiation of bone ‐marrow derived human mesenchymal stem cells (hMSC) can be induced by stimulation with either canonical Notch ligand, Jagged1, or bone morphogenetic proteins (BMP). However, it remains elusive how these two pathways lead to the ...
Source: Stem Cells - June 13, 2020 Category: Stem Cells Authors: Yadav Wagley, Alessandra Chesi, Parker K. Acevedo, Sumei Lu, Andrew D. Wells, Matthew E. Johnson, Struan F. A. Grant, Kurt D. Hankenson Tags: Tissue ‐Specific Stem Cells Source Type: research

TGF ‐β secreted by human umbilical cord blood‐derived mesenchymal stem cells ameliorates atopic dermatitis by inhibiting secretion of TNF‐α and IgE
This study investigated the role of transforming growth factor‐beta (TGF‐β) in the therapeutic effect of hUCB‐MSCs on AD. Small interfering RNA (siRNA)‐ mediated depletion of TGF‐β disrupted the therapeutic effect of hUCB‐MSCs in a mouse model of AD by attenuating the beneficial changes in histopathology, mast cell infiltration, tumor necrosis factor‐alpha (TNF‐α) expression, and the serum IgE level. To confirm that hUCB‐MSCs regulate se cretion of TNF‐α, we investigated whether they inhibit TNF‐α secretion by activated LAD2 cells. Coculture with hUCB‐MSCs significantly inhibited secretion of T...
Source: Stem Cells - April 13, 2020 Category: Stem Cells Authors: Hwan hee Park, Seunghee Lee, Yeonsil Yu, Sae Mi Yoo, Song Yi Baek, Namhee Jung, Kwang ‐Won Seo, Kyung‐Sun Kang Tags: Translational and Clinical Research Source Type: research

Nanocarrier mediated siRNA delivery targeting stem cell differentiation.
Abstract Stem cell based regenerative medicine holds exceptional therapeutic potential and hence the development of efficient techniques to enhance control over the rate of differentiation has been the focus of active research. One of the strategies to achieve this involves delivering siRNA into stem cells and exploiting the RNA interference (RNAi) mechanism. Transport of siRNA across the cell membrane is a challenge due to its anionic property, especially in primary human cells and stem cells. Moreover, naked siRNA incites immune responses, may cause off-target effects, exhibits low stability and is easily degrad...
Source: Current Stem Cell Research and Therapy - November 30, 2019 Category: Stem Cells Authors: Fernandes F, Kotharkar P, Chakravorty A, Kowshik M, Talukdar I Tags: Curr Stem Cell Res Ther Source Type: research

Lysophosphatidic acid receptor 4 regulates osteogenic and adipogenic differentiation of progenitor cells via inactivation of RhoA/ROCK1/ β‐catenin signaling
This study has demonstrated that ras homolog family member A (RhoA), along with its major effector, Rho ‐associated kinases 1 (ROCK1) activates β‐catenin signaling to promote osteogenic differentiation and restrain adipogenic differentiation. Lysophosphatidic acid (LPA) receptor 4 (LPAR4), one of the receptors of LPA, blocks the activation of RhoA/ROCK1/β‐catenin signaling pathway, and thereby reciprocally regulates osteogenic and adipogenic differentiation of mesenchymal progenitor cellsin vitro andin vivo. The study suggests the potential of LPAR4 as a pharmaceutical target to treat metabolic disorders such as osteoporosis.
Source: Stem Cells - November 27, 2019 Category: Stem Cells Authors: Yan Xie, Xiaochen Wang, Xiaowen Wu, Lijie Tian, Jie Zhou, Xiaoxia Li, Baoli Wang Tags: Tissue ‐Specific Stem Cells Source Type: research

Chemical activation of the Piezo1 channel drives mesenchymal stem cell migration via inducing ATP release and activation of P2 receptor purinergic signalling
In this study, we show the expression of the Ca2+‐permeable Piezo1 channel, a newly‐discovered mechanosensing mechanism, in human dental pulp‐derived MSC and its important role in the regulation of MSC migration. We further demonstrate that activation of the Piezo1 channel stimulates MSC migration via inducing ATP release and subsequent acti vation of P2 receptor purinergic signaling. Our study thus provide novel insights into the mechanisms regulating MSC migration. Such information is useful for gaining a better understanding of MSC migration and designing strategies to improve applications of MSC in tissue enginee...
Source: Stem Cells - November 18, 2019 Category: Stem Cells Authors: Fatema Mousawi, Hongsen Peng, Jing Li, Ponnambalam Sreenivasan, Sebastian Roger, Hucheng Zhao, Xuebin Yang, Lin ‐Hua Jiang Tags: Tissue ‐Specific Stem Cells Source Type: research

BCR-Abl Silencing by siRNA: A Potent Approach to Sensitize Chronic Myeloid Leukemia Cells to Tyrosine Kinase Inhibitor Therapy
Stem Cells and Development,Volume 28, Issue 11, Page 734-744, June 1, 2019.
Source: Stem Cells and Development - June 2, 2019 Category: Stem Cells Authors: Remant KC Bindu Thapa Anyeld Ubeda Xiaoyan Jiang Hasan Uluda ğ Source Type: research

Sufficiency of hypoxia-inducible 2-oxoglutarate dioxygenases to block chemical oxidative stress-induced differentiation of human embryonic stem cells
Publication date: Available online 12 December 2018Source: Stem Cell ResearchAuthor(s): Eirini Koutsouraki, Steve Pells, Paul A. De SousaAbstractHypoxia benefits undifferentiated pluripotent stem cell renewal, and 2-oxoglutarate (2OG) dioxygenases have been implicated in pluripotent stem cell induction and renewal. We show in human embryonic stem cells (hESC) that an ambient oxygen-induced oxidative stress response elicited by culture in a hypoxic atmosphere (0.5% O2) correlates with the expression of 2OG dioxygenases, which oxidise DNA (TET1, 2, 3) and histone H3 (KDM4C), the former reflected by elevation in genomic 5-hyd...
Source: Stem Cell Research - December 12, 2018 Category: Stem Cells Source Type: research

Markers of Accelerated Skeletal Muscle Regenerative Response in MRL/MpJ Mice: Characteristics of Muscle Progenitor Cells and Circulating Factors
This study suggests that a combination of MPCs and modulating antio xidative stress can represent a novel therapy to improve muscle healing after injury, disease, and aging.© AlphaMed Press 2018
Source: Stem Cells - December 10, 2018 Category: Stem Cells Authors: Chieh Tseng, Krishna Sinha, Haiying Pan, Yan Cui, Ping Guo, Chih Yi Lin, Fan Yang, Zhenhan Deng, Holger K. Eltzschig, Aiping Lu, Johnny Huard Tags: Regenerative Medicine Source Type: research

EDG5 plays an important role in induction and maintenance of pluripotency
Graphical abstract summarizing the main findings generated from this study. AbstractDirect reprogramming of human somatic cells toward induced pluripotent stem cells holds great promise for regenerative medicine and basic biology. We used a high ‐throughput siRNA screening assay in the initiation phase of reprogramming for 784 genes belonging to kinase and phosphatase families and identified 68 repressors and 22 effectors. Six new candidates belonging to the family of the G protein–coupled receptors (GPCRs) were identified suggesting an important role for this key signalling pathway during somatic cell induced reprogra...
Source: Stem Cells - December 4, 2018 Category: Stem Cells Authors: Irina Neganova, Lewis Cotts, Peter Banks, Katja Gassner, Lyle Armstrong, Graham Ladds, Majlinda Lako Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research

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