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Assessment of cervical lymph node metastasis based on total RNA from saliva and tumor tissue in patients with oral squamous cell carcinoma: An observational study
Conclusion: Saliva and tumor tissue RNA can be a good marker for pretreatment assessment of lymph node metastasis in patients with OSCC. Although the diagnostic accuracy which range from 63% to 65%, further characterization and study of specific mRNA, siRNA and miRNA may come out with high diagnostic accuracy.
Source: Journal of Oral and Maxillofacial Pathology - September 8, 2020 Category: ENT & OMF Authors: Kiran B Jadhav Vandana Shah Ghansham Parmar Nirali Chauhan Naveen Shah Nidhi Gupta Source Type: research

Ladinin-1 is involved in cell motility and proliferation of oral squamous cell carcinoma cells
ConclusionsLAD1 is potentially involved in modulation of actin dynamics in oral SCC cells, affecting their motility and proliferation at the interface between cancer and non-cancerous tissue.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - June 13, 2019 Category: ENT & OMF Source Type: research

Epidermal growth factor receptor inhibition by anti‐CD147 therapy in cutaneous squamous cell carcinoma
ConclusionInhibition and downregulation of CD147 in cutaneous SCC resulted in suppression of the malignant phenotype in vitro and in vivo, which may be mediated in part by an alteration in EGFR expression. As a result, CD147 may serve as a potential therapeutic target for advanced cutaneous SCC. © 2014 Wiley Periodicals, Inc. Head Neck, 2015
Source: Head and Neck - June 16, 2015 Category: ENT & OMF Authors: John W. Frederick, Larissa Sweeny, Yolanda Hartman, Tong Zhou, Eben L. Rosenthal Tags: Original Article Source Type: research

EGFR inhibition by anti‐CD147 therapy in Cutaneous Squamous cell Carcinoma
Conclusions: Inhibition and down‐regulation of CD147 in cSCC resulted in suppression of the malignant phenotype in vitro and in vivo which may be mediated in part by an alteration in EGFR expression. As a result, CD147 may serve as a potential therapeutic target for advanced cSCC. Head Neck, 2014
Source: Head and Neck - October 1, 2014 Category: ENT & OMF Authors: John W. Frederick, Larissa Sweeny, Yolanda Hartman, Tong Zhou, Eben L. Rosenthal Tags: Original Article Source Type: research

In vitro study of normoxic epidermal growth factor receptor–induced hypoxia‐inducible factor‐1‐alpha, vascular endothelial growth factor, and BNIP3 expression in head and neck squamous cell carcinoma cell lines: Implications for anti–epidermal growth factor receptor therapy
ConclusionThe search for molecular predictors of sensitivity to gefitinib in HNSCC should be extended to the activation status of EGFR‐downstream pathways, phosphorylated protein kinase B, pMAPK, and HIF‐1α. © 2014 Wiley Periodicals, Inc. Head Neck, 2014
Source: Head and Neck - July 7, 2014 Category: ENT & OMF Authors: Pablo Secades, Inés Saenz Santa‐María, Anna Merlo, Carlos Suarez, María‐Dolores Chiara Tags: Original Article Source Type: research

In vitro study of normoxic epidermal growth factor (EGF)‐induced HIF‐1α, VEGF and BNIP3 expression in head and neck squamous cell carcinoma cell lines: implications for anti‐EGFR therapy
Conclusions The search for molecular predictors of sensitivity to gefitinib in HNSCC should be extended to the activation status of EGFR‐downstream pathways, pAkt, pMAPK, and HIF‐1α. Head Neck, 2014
Source: Head and Neck - May 2, 2014 Category: ENT & OMF Authors: Pablo Secades, Inés Saenz de Santamaría, Anna Merlo, Carlos Suarez, María‐Dolores Chiara Tags: Original Article Source Type: research

NFκB Silencing Induces Chromatin Acetylation and Ablates Resistance to Cisplatin in Head and Neck Cancer
Conclusion: Our results suggest that HDAC inhibitors and NFκB targeted therapies may represent viable adjuvant chemotherapy to revert HNSCC resistant to platinum-based therapies.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - January 21, 2014 Category: ENT & OMF Authors: ALINE CORREA ABRAHAO, LUCIANA O. ALMEIDA, LUCIANA K. ROSSELLI-MURAI, FERNANDA S. GIUDICE, ANDREIA M. LEOPOLDINO, CRISTIANE H. SQUARIZE, ROGERIO M. CASTILHO Tags: Online Only Articles Source Type: research

Relation between the expression of mitotic centromere–associated kinesin and the progression of squamous cell carcinoma of the tongue
Objective: Mitotic centromere–associated kinesin (MCAK) is a microtubule depolymerase indispensable for microtubule binding during spindle formation. The purpose of this study was to investigate the association of MCAK expression with squamous cell carcinoma of the oral tongue (SCCOT).Study Design: Immunohistochemistry was used in 47 cases of SCCOT. Determination of proliferation and migratory capabilities was performed with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and Transwell chamber assay, respectively, on cells from the human tongue squamous cell carcinoma cell line Tca8113 that were ...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - November 22, 2013 Category: ENT & OMF Authors: Cheng-Qin Wang, Feng-Gang Xiang, Yu-Jun Li, Xiao-Ming Xing, Ning Wang, Jing-Hua Chi, Wen-Juan Yu Tags: Oral and Maxillofacial Pathology Source Type: research

HRAS mutations and resistance to the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in head and neck squamous cell carcinoma cells
Conclusion: Activating HRAS mutations can confer erlotinib resistance in an HRAS mutant HNSCC cell line. Head Neck, 2013.
Source: Head and Neck - September 30, 2013 Category: ENT & OMF Authors: J. Hun Hah, Mei Zhao, Curtis R. Pickering, Mitchell J. Frederick, Genevieve A. Andrews, Samar A. Jasser, David R. Fooshee, Zvonimir L. Milas, Chad Galer, Daisuke Sano, William N. William, Edward Kim, John Heymach, Lauren A. Byers, Vali Papadimitrakopoulou Tags: Research Article Source Type: research

Gene silencing with siRNA targeting E6/E7 as a therapeutic intervention against head and neck cancer-containing HPV16 cell lines.
Conclusion: Our results indicate that siRNA E6 and/or E7 may have potential as a gene-specific therapy for human papillomavirus (HPV) type 16 (HPV16)-related squamous cell carcinoma of the head and neck (HNSCC). Objectives: To evaluate the effectiveness of siRNA targeting E6 and/or E7 on the in vitro and in vivo growth suppression of HPV16-related HNSCC. Methods: HPV16-related HNSCC (UM-SCC47) cell lines were used for the present study. Expression of HPV viral oncogenes E6 and/or E7 and their cellular targets, p53 and pRb, was evaluated by real-time PCR, Western blotting, and immunofluorescence staining. To study the effec...
Source: Acta Oto-Laryngologica - May 3, 2013 Category: ENT & OMF Authors: Adhim Z, Otsuki N, Kitamoto J, Morishita N, Kawabata M, Shirakawa T, Nibu KI Tags: Acta Otolaryngol Source Type: research

Stable gene-silence of Kif2a synergistic with 5-fluorouracil suppresses oral tongue squamous cell carcinoma growth in vitro and in vivo
Conclusions: Our data support that Kif2a is a potential molecular target for the therapeutics of recurrent and metastatic SCCOT.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 8, 2013 Category: ENT & OMF Authors: Cheng-Qin Wang, Yu-Jun Li, Zhi-Min Wei, Chang-Jun Zhu, Xun Qu, Feng-Cai Wei, Xiao-Ming Xing, Wen-Juan Yu Tags: Oral Medicine Source Type: research