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Specialty: Endocrinology
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Total 391 results found since Jan 2013.

Reversal of dual epigenetic repression of non-canonical Wnt-5a normalises diabetic corneal epithelial wound healing and stem cells
Conclusions/interpretationWe provide the first account of epigenetic changes in diabetic corneas including dual inhibition ofWNT5A by DNA methylation and miRNA action. Overall, Wnt-5a is a new corneal epithelial wound healing stimulator that can be targeted to improve wound healing and stem cells in the diabetic cornea.Data availabilityThe DNA methylation dataset is available from the public GEO repository under accession no. GSE229328 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE229328).Graphical Abstract
Source: Diabetologia - September 3, 2023 Category: Endocrinology Source Type: research

Aberrant PI3K δ splice isoform as a potential biomarker and novel therapeutic target for endocrine cancers
ConclusionIn summary, our study has suggested a promising potential of utilizing PI3Kδ-S (an oncogenic isoform conferring drug resistance and exempt from PTEN regulation) as a prognostic biomarker and drug target in advanced endocrine cancers.
Source: Frontiers in Endocrinology - August 21, 2023 Category: Endocrinology Source Type: research

Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets
Conclusions/interpretationFFA1 promotes glucose-responsive insulin secretion and functional maturation of newborn islets and is required for adaptive offspring insulin secretion in the face of metabolic challenge, such as parental HFD.Graphical Abstract
Source: Diabetologia - July 3, 2023 Category: Endocrinology Source Type: research

Chaperonin counteracts diet-induced non-alcoholic fatty liver disease by aiding sirtuin 3 in the control of fatty acid oxidation
Conclusion/interpretationMitochondrial HSP60 promotes fatty acid oxidation while repressing mitochondrial stress and inflammation to ameliorate the development of NAFLD by preserving SIRT3 signalling. This study reveals the hepatoprotective effects of HSP60 and indicates that HSP60 could play a fundamental role in the development of therapeutics for NAFLD or type 2 diabetes.Graphical abstract
Source: Diabetologia - March 24, 2023 Category: Endocrinology Source Type: research

A large-scale screening and functional sorting of tumour microenvironment prognostic genes for breast cancer patients
ConclusionsThis integrated study hypothesised an innovative TME-associated genetic functional network for breast cancer patients. The external relationships between these TME prognostic genes and the disease were measured. Meanwhile, the internal molecular mechanisms were also investigated.
Source: Frontiers in Endocrinology - March 1, 2023 Category: Endocrinology Source Type: research

5-Iodotubercidin Inhibits the Growth of Insulinoma Cells by Inducing Apoptosis
Conclusions: 5-iodotubercidin induce DNA damage leading to insulinoma cells apoptosis by activating ATM/p53 pathway. Therefore, this is a potential strategy for treating Insulinoma.
Source: Neuroendocrinology - February 9, 2023 Category: Endocrinology Source Type: research

BASP1 promotes high glucose ‐induced endothelial apoptosis in diabetes via activation of EGFR signaling
ConclusionBASP1 promotes endothelial cell injury induced by high glucose in patients with diabetes, which may be activated by activating the EGFR pathway.
Source: Journal of Diabetes Investigation - February 9, 2023 Category: Endocrinology Authors: Fengnan Sun, Junwei Liu, Yanzheng Wang, Hongmei Yang, Danfeng Song, Haiyan Fu, Xingxing Feng Tags: Original Article Source Type: research

Advanced glycation end products induce skeletal muscle atrophy and insulin resistance via activating ROS-mediated ER stress PERK/FOXO1 signaling
In this study, we investigated whether AGEs could exacerbate skeletal muscle atrophy and its related insulin resistance. Mice were exposed to AGEs. Forkhead box O1 (FOXO1) was silenced by a constructed viral vector carrying siRNA. Skeletal muscle atrophy was evaluated by H&E, oil red O, myosin skeletal heavy chain (MHC) and laminin immunofluorescent stains. Reactive oxygen species (ROS) generation was assessed by DHE stain. Western blotting was used to evaluate protein expression and phosphorylation. Insulin resistance was monitored by insulin tolerance test (ITT) and glucose infusion rate (GIR). Mice exposed to AGEs s...
Source: Am J Physiol Endocri... - February 1, 2023 Category: Endocrinology Authors: Haixia Du Yanpeng Ma Xiqiang Wang Yong Zhang Ling Zhu Shuang Shi Shuo Pan Zhongwei Liu Source Type: research