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Procedure: Liver Transplant
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Total 111 results found since Jan 2013.
Petits ARN interf érents : applications potentielles pour les néphrologues Small interfering RNA: potential applications for nephrologists
Nephrol Ther. 2022 Dec;18(6S1):6S1-6S6. doi: 10.1016/S1769-7255(22)00646-0.ABSTRACTSmall interfering RNA (siRNAs) are double-stranded RNAs of around 20 base pairs in length that trigger RNAi machinery, which promotes degradation of a target mRNA avoiding protein translation. SiRNAs are liver-targeted, using tris N-acetylgalactosamine (GalNAc) as the targeting ligand. This discovery received the Nobel Prize for medicine and physiology in 2006 and lead to substantial therapeutic advances. Application field and development of these siRNA has been very fast. Indeed, patisiran has been released in 2018 for hereditary transthyre...
Source: Nephrologie and Therapeutique - December 30, 2022 Category: Urology & Nephrology Authors: Sandrine Lemoine Marie Courbebaisse Source Type: research
Regulation of Heme Oxygenase 1 Expression by miR-27b With Stem Cell Therapy for Liver Regeneration in Rats
In this study, we studied the role of miR-27b in ASCs and their regenerative potential after partial liver resection in rats. ASCs transfected with control siRNA or miR-27b were intravenously injected into autologous rats undergoing 70% partial hepatectomy (PH). Our data showed that the regenerative capacities of ASCs with overexpressed miR-27b were significantly higher compared with control ASCs. However, the enhanced regeneration, hepatic differentiation, and suppressed liver inflammation, as well as fibrotic activity, were significantly reverted by ZnPP coadministration (heme oxygenase-1 [HO-1] inhibitor) indicating an ...
Source: Transplantation Proceedings - May 1, 2014 Category: Transplant Surgery Authors: K.-D. Chen, L.-W. Hsu, S. Goto, K.-T. Huang, T. Nakano, W.-T. Weng, C.-Y. Lai, Y.-R. Kuo, K.-W. Chiu, C.-C. Wang, Y.-F. Cheng, C.-C. Lin, Y.-Y. Ma, C.-L. Chen Tags: Experimental Transplantation Source Type: research
Platelet factor 4 limits Th17 differentiation and ischemia‐reperfusion injury after liver transplantation in mice
In conclusion, PF4 limits liver IRI through IL‐17 inhibition via up‐regulation of SOCS3.
This article is protected by copyright. All rights reserved.
Source: Scandinavian Journal of Immunology - November 29, 2014 Category: Allergy & Immunology Authors: Hefeng Guo, Zhiming Zhao, Yue Wang Tags: Regular Manuscript Source Type: research
Platelet Factor 4 Limits Th17 Differentiation and Ischaemia–Reperfusion Injury After Liver Transplantation in Mice
In conclusion, PF4 limits liver IRI through IL‐17 inhibition via upregulation of SOCS3.
Source: Scandinavian Journal of Immunology - January 20, 2015 Category: Allergy & Immunology Authors: H. Guo, Y. Wang, Z. Zhao, X. Shao Tags: Experimental Immunology Source Type: research
Delivery and Targeting of miRNAs for Treating Liver Fibrosis
Abstract
Liver fibrosis is a pathological condition originating from liver damage that leads to excess accumulation of extracellular matrix (ECM) proteins in the liver. Viral infection, chronic injury, local inflammatory responses and oxidative stress are the major factors contributing to the onset and progression of liver fibrosis. Multiple cell types and various growth factors and inflammatory cytokines are involved in the induction and progression of this disease. Various strategies currently being tried to attenuate liver fibrosis include the inhibition of HSC activation or induction of their apoptosis, reduc...
Source: Pharmaceutical Research - January 24, 2015 Category: Drugs & Pharmacology Source Type: research
Pharmacological strategies for protection of extrahepatic islet transplantation.
This article gathers courses and conditions that lead to islet loss, from organ procurement through islet transplantation, with special emphasis on hypoxia, oxidative stress, and antigen non-specific inflammation, and reviews strategies using pharmacological agents that have shown effectiveness in protecting islets, including a new treatment approach utilizing siRNA. Pharmacological agents that support islet survival and promote β-cell proliferation are also included. Treatment of donor pancreata and/or islets with these agents should increase the effectiveness of islets transplanted into extrahepatic sites. Furthermore, ...
Source: Minerva Endocrinologica - June 4, 2015 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
RNA Interference as a Therapeutic Strategy for the Treatment of Liver Diseases.
Abstract
RNA interference has emerged as an innovative technology for gene silencing that degrades mRNAs complementary to the antisense strands of double-stranded, short interfering RNAs (siRNAs). Its therapeutic application has important advantages over small-molecule drugs since offers the possibility of targeting virtually all genes and allows selective silencing of one or several genes. So far, a relative small proportion of cellular proteins can bind and respond to chemical drugs. Based on that, RNA interference-mediated gene silencing is widely considered as a crucial breakthrough in molecular biology with a...
Source: Current Pharmaceutical Design - October 23, 2015 Category: Drugs & Pharmacology Authors: Gonzalez-Rodriguez A, Valverde AM Tags: Curr Pharm Des Source Type: research
HERC5 is a prognostic biomarker for post-liver transplant recurrent human hepatocellular carcinoma
Conclusions:
HERC5 plays a crucial role in HCC immune evasion and has clinical relevance as a reproducible prognostic marker for risk of tumor recurrence and survival in patients.
Source: Journal of Translational Medicine - December 11, 2015 Category: Research Authors: Feng XueBrandon HiggsJiaqi HuangChris MorehouseWei ZhuXin YaoPhilip BrohawnZhan XiaoYinong SebastianZheng LiuYun XiaDong ShenMike KuzioraZhengwei DongHulin HanYi GuJianren GuQiang XiaYihong Yao Source Type: research
Identification of NUCKS1 as a putative oncogene and immunodiagnostic marker of hepatocellular carcinoma.
Abstract
Although the molecular mechanisms underpinning hepatocellular carcinoma (HCC) are unknown, gene copy number and associated mRNA expression changes are frequently reported. Comparative genomic hybridization arrays spotted with 4041 bacterial artificial chromosome clones were used to assess copy number changes in 45 HCC tissues. Seventy more HCC tissues were used to validate candidate genes by using western blots and immunohistochemistry. A total of 259 clones were associated with copy number changes that significantly differed between normal liver and HCC samples. The chromosomal region 1q32.1 containing t...
Source: Gene - March 8, 2016 Category: Genetics & Stem Cells Authors: Cheong JY, Kim YB, Woo JH, Kim DK, Yeo M, Yang SJ, Yang KS, Soon SK, Wang HJ, Kim BW, Park JH, Cho SW Tags: Gene Source Type: research
New role and molecular mechanism of Gadd45a in hepatic fibrosis.
CONCLUSION: Gadd45a may counteract hepatic fibrosis by regulating the activation of HSCs via the inhibition of TGF-β/Smad signaling.
PMID: 26973416 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - March 7, 2016 Category: Gastroenterology Authors: Hong L, Sun QF, Xu TY, Wu YH, Zhang H, Fu RQ, Cai FJ, Zhou QQ, Zhou K, Du QW, Zhang D, Xu S, Ding JG Tags: World J Gastroenterol Source Type: research
