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Total 92 results found since Jan 2013.
Upregulation of miR-93 and inhibition of LIMK1 improve ventricular remodeling and alleviate cardiac dysfunction in rats with chronic heart failure by inhibiting RhoA/ROCK signaling pathway activation.
CONCLUSION: Our study provides evidence that upregulated miR-93 and downregulated LIMK1 improve ventricular remodeling and reduce cardiac dysfunction in CHF rats by inhibiting RhoA/ROCK signaling pathway activation.
METHODS: First, rat models of CHF were established by aortic coarctation, and the rats were injected with miR-93 mimics, LIMK1-siRNA or overexpressed-LIMK1. Then expression of miR-93, LIMK1, RhoA, and ROCK1 expression in myocardial tissues were detected, after which indices of cardiac ultrasound, hemodynamics, and oxidative stress, inflammatory factors, apoptosis-related indicators were detected via a seri...
Source: Aging - September 19, 2019 Category: Biomedical Science Authors: Su Q, Zhang P, Yu D, Wu Z, Li D, Shen F, Liao P, Yin G Tags: Aging (Albany NY) Source Type: research
Low-intensity Pulsed Ultrasound regulates alveolar bone homeostasis in experimental Periodontitis by diminishing Oxidative Stress
Conclusions: These results demonstrated that LIPUS regulates alveolar bone homeostasis in periodontitis by attenuating oxidative stress via the regulation of PI3K-Akt/Nrf2 signaling. Thus, Nrf2 plays a pivotal role in the protective effect exerted by LIPUS against ligature-induced experimental periodontitis.
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Siqi Ying, Minmin Tan, Ge Feng, Yunchun Kuang, Duanjing Chen, Jie Li, Jinlin Song Tags: Research Paper Source Type: research
Temporary opening of the blood-brain barrier with the nitrone compound OKN-007
This study demonstrates that OKN-007 may be able to temporarily open up the BBB to augment the delivery of various compounds ranging in MW from as small as ~550 to as large as ~470 kDa. This compound is an investigational new drug for glioblastoma (GBM) therapy in clinical trials. The translational capability for human use to augment the delivery of non-BBB-permeable drugs is extremely high.PMID:34754607 | PMC:PMC8569329
Source: Molecular Medicine - November 10, 2021 Category: Molecular Biology Authors: Rheal A Towner Debra Saunders Megan Lerner Robert Silasi Mansat Tian Yuan Dylan Barber Janet Faakye Adam Nyul-Toth Anna Csiszar Beverley Greenwood-Van Meerveld Nataliya Smith Source Type: research
Gene therapy: Comprehensive overview and therapeutic applications
Life Sci. 2022 Feb 3:120375. doi: 10.1016/j.lfs.2022.120375. Online ahead of print.ABSTRACTGene therapy is the product of man's quest to eliminate diseases. Gene therapy has three facets namely, gene silencing using siRNA, shRNA and miRNA, gene replacement where the desired gene in the form of plasmids and viral vectors, are directly administered and finally gene editing based therapy where mutations are modified using specific nucleases such as zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and clustered regulatory interspaced short tandem repeats (CRISPR)/CRISPR-associated protein ...
Source: Cell Research - February 6, 2022 Category: Cytology Authors: Nilofer Sayed Prince Allawadhi Amit Khurana Vishakha Singh Umashanker Navik Sravan Kumar Pasumarthi Isha Khurana Anil Kumar Banothu Ralf Weiskirchen Kala Kumar Bharani Source Type: research
Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research
A hybrid nanoassembly for ultrasound-inducible cytosolic siRNA delivery and cancer sono-gene therapy
Ultrason Sonochem. 2022 Dec 9;92:106262. doi: 10.1016/j.ultsonch.2022.106262. Online ahead of print.NO ABSTRACTPMID:36512940 | DOI:10.1016/j.ultsonch.2022.106262
Source: Ultrasonics Sonochemistry - December 13, 2022 Category: Chemistry Authors: Gaigai Li Yan Zhang Jinbo Li Source Type: research
