Temporary opening of the blood-brain barrier with the nitrone compound OKN-007

This study demonstrates that OKN-007 may be able to temporarily open up the BBB to augment the delivery of various compounds ranging in MW from as small as ~550 to as large as ~470 kDa. This compound is an investigational new drug for glioblastoma (GBM) therapy in clinical trials. The translational capability for human use to augment the delivery of non-BBB-permeable drugs is extremely high.PMID:34754607 | PMC:PMC8569329

Source: Molecular Medicine - November 10, 2021 Category: Molecular Biology Authors: Rheal A Towner Debra Saunders Megan Lerner Robert Silasi Mansat Tian Yuan Dylan Barber Janet Faakye Adam Nyul-Toth Anna Csiszar Beverley Greenwood-Van Meerveld Nataliya Smith Source Type: research