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Total 35 results found since Jan 2013.

Autophagy suppresses radiation damage by activating PARP-1 and attenuating reactive oxygen species in hepatoma cells.
CONCLUSION: Autophagy upregulates the expression of PARP-1 and relieves radiation damage by reducing the generation of ROS. PMID: 30964366 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - April 10, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research

DCLK1 Inhibition Sensitizes Colorectal Cancer Cells to Radiation Treatment
Int J Mol Cell Med. 2021 Winter;10(1):23-33. doi: 10.22088/IJMCM.BUMS.10.1.23. Epub 2021 May 22.ABSTRACTColorectal cancer (CRC) is one of the most prevalent diagnosed cancers and a common cause of cancer-related mortality. Despite effective clinical responses, a large proportion of patients undergo resistance to radiation therapy. Therefore, the identification of efficient targeted therapy strategies would be beneficial to overcome cancer radioresistance. Doublecortin-like kinase 1 (DCLK1) is an intestinal and pancreatic stem cell marker that showed overexpression in a variety of cancers. The transfection of DCLK1 siRNA to...
Source: Molecular Medicine - July 16, 2021 Category: Molecular Biology Authors: Chiman Mohammadi Ali Mahdavinezhad Massoud Saidijam Fatemeh Bahreini Abdolazim Sedighi Pashaki Mohammad Hadi Gholami Rezvan Najafi Source Type: research

Anti-miRNA-221 sensitizes human colorectal carcinoma cells to radiation by upregulating PTEN.
CONCLUSION: Anti-miR-221 can enhance the radiosensitivity of CRC cells by upregulating PTEN. PMID: 24409057 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 28, 2013 Category: Gastroenterology Authors: Xue Q, Sun K, Deng HJ, Lei ST, Dong JQ, Li GX Tags: World J Gastroenterol Source Type: research

p21 is Responsible for Ionizing Radiation-induced Bypass of Mitosis.
CONCLUSION: Our results indicated that p21 was responsible for the downregulation of G2/M transition regulatory proteins and the bypass of mitosis induced by irradiation. Downregulation of p21 by siRNA resulted in G2-arrested cells entering into mitosis with serious DNA damage. This is the first report on elucidating the role of p21 in the bypass of mitosis. PMID: 27554118 [PubMed - in process]
Source: Biomedical and Environmental Sciences : BES - June 30, 2016 Category: Biomedical Science Authors: Zhang XR, Liu YA, Sun F, Li H, Lei SW, Wang JF Tags: Biomed Environ Sci Source Type: research

p21 is Responsible for Ionizing Radiation-induced Bypass of Mitosis
Conclusion Our results indicated that p21 was responsible for the downregulation of G2/M transition regulatory proteins and the bypass of mitosis induced by irradiation. Downregulation of p21 by siRNA resulted in G2-arrested cells entering into mitosis with serious DNA damage. This is the first report on elucidating the role of p21 in the bypass of mitosis.
Source: Biomedical and Environmental Sciences - August 30, 2016 Category: Biomedical Science Source Type: research

USP9X Is Required to Maintain Cell Survival in Response to High-LET Radiation
Ionizing radiation (IR) principally acts through induction of DNA damage that promotes cell death, although the biological effects of IR are more broad ranging. In fact, the impact of IR of higher-linear energy transfer (LET) on cell biology is generally not well understood. Critically, therefore, the cellular enzymes and mechanisms responsible for enhancing cell survival following high-LET IR are unclear. To this effect, we have recently performed siRNA screening to identify deubiquitylating enzymes that control cell survival specifically in response to high-LET α-particles and protons, in comparison to low-LET X-rays an...
Source: Frontiers in Oncology - July 1, 2021 Category: Cancer & Oncology Source Type: research

Radiation Induces Bone Microenvironment Disruption by Activating the STING-TBK1 Pathway
Conclusions: The STING-P-TBK1 signaling pathway plays a crucial role in the regulation of the secretion of inflammatory cytokines and osteoclastogenesis potential in IR-induced bone microenvironment disruption. The selective STING antagonist can be used to intervene to block the STING pathway and, thereby, repair IR-induced multicellular biological damage and mitigate the imbalance between osteoclastogenesis and osteoblastgenesis.PMID:37512126 | DOI:10.3390/medicina59071316
Source: Medicina (Kaunas) - July 29, 2023 Category: Universities & Medical Training Authors: Yuyang Wang Li Ren Linshan Xu Jianping Wang Jianglong Zhai Guoying Zhu Source Type: research