p21 is Responsible for Ionizing Radiation-induced Bypass of Mitosis

Conclusion Our results indicated that p21 was responsible for the downregulation of G2/M transition regulatory proteins and the bypass of mitosis induced by irradiation. Downregulation of p21 by siRNA resulted in G2-arrested cells entering into mitosis with serious DNA damage. This is the first report on elucidating the role of p21 in the bypass of mitosis.
Source: Biomedical and Environmental Sciences - Category: Biomedical Science Source Type: research