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Radiation Induces Bone Microenvironment Disruption by Activating the STING-TBK1 Pathway
Conclusions: The STING-P-TBK1 signaling pathway plays a crucial role in the regulation of the secretion of inflammatory cytokines and osteoclastogenesis potential in IR-induced bone microenvironment disruption. The selective STING antagonist can be used to intervene to block the STING pathway and, thereby, repair IR-induced multicellular biological damage and mitigate the imbalance between osteoclastogenesis and osteoblastgenesis.PMID:37512126 | PMC:PMC10386124 | DOI:10.3390/medicina59071316
Source: Medicina (Kaunas) - July 29, 2023 Category: Universities & Medical Training Authors: Yuyang Wang Li Ren Linshan Xu Jianping Wang Jianglong Zhai Guoying Zhu Source Type: research

Down-regulation of BTG1 by miR-454-3p enhances cellular radiosensitivity in renal carcinoma cells
Conclusions: Our results indicate that BTG1 is a direct target of miR-454-3p. Down-regulation of BTG1 by miR-454-3p renders tumor cells sensitive to radiation. These results may shed light on the potential application in tumor radiotherapy.
Source: Radiation Oncology - August 12, 2014 Category: Cancer & Oncology Authors: Xin WuNan DingWentao HuJinpeng HeShuai XuHailong PeiJunrui HuaGuangming ZhouJufang Wang Source Type: research

Radiation Exposure Promotes Hepatocarcinoma Cell Invasion through Epithelial Mesenchymal Transition Mediated by H2S/CSE Pathway.
In this study, we found that exposure to X rays promoted cell invasion by triggering the epithelial mesenchymal transition (EMT) in two hepatocellular carcinoma (HCC) cell lines, HepG2 and PLC/PRF/5. This was made evident by a reduced expression of E-cadherin and enhanced expressions of N-cadherin, Vimentin and Snail. Moreover, exposure to radiation stimulated the signaling of hydrogen sulfide (H2S), a newly found gas transmitter, by upregulating the expressions of H2S-producing proteins of cysthionine-γ-lyase (CSE), cystathionine-β-synthase (CBS). Inhibition of CSE by siRNA or inhibitor not only increased the radiosensi...
Source: Radiation Research - January 4, 2016 Category: Physics Authors: Pan Y, Zhou C, Yuan D, Zhang J, Shao C Tags: Radiat Res Source Type: research

Role of Heme Oxygenase-1 in Low Dose Radioadaptive Response
In this study, we focused on the possible role of heme oxygenase 1 (HO-1) in RAR. Consistent with previous studies, priming dose of X-ray radiation (1-10cGy) induced significant RAR in normal human skin fibroblasts (AG 1522 cells). Transcription and translation of HO-1 was up-regulated more than two fold by a priming dose of radiation (5cGy). Zinc protoporphyrin Ⅸ, a specific competitive inhibitor of HO-1, efficiently inhibited RAR whereas hemin, an inducer of HO-1, could mimic priming dose of X-rays to induce RAR. Knocking down of HO-1 by transfection of HO-1 siRNA significantly attenuated RAR. Furthermore, the expressi...
Source: Redox Biology - March 5, 2016 Category: Biology Source Type: research

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