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Contribution of microRNA ‐27b‐3p to synovial fibrotic responses in knee osteoarthritis
ConclusionsThis study demonstrates a key role of miR-27b-3p in ECM regulation associated with synovial fibrosis during OA.
Source: Arthritis and Rheumatology - July 6, 2022 Category: Rheumatology Authors: Ghazaleh Tavallaee, Starlee Lively, Jason S. Rockel, Shabana Amanda Ali, Michelle Im, Clementine Sarda, Greniqueca M. Mitchell, Evgeny Rossomacha, Sayaka Nakamura, Pratibha Potla, Sarah Gabrial, John Matelski, Anusha Ratneswaran, Kim Perry, Tags: Full Length Source Type: research

Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research

Knockdown of SERPINB2 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the Wnt/ β-catenin signalling pathway
CONCLUSIONS: Taken together, these findings indicate that SERPINB2 silencing promoted osteogenic differentiation of BMSCs via the Wnt/β-catenin signaling pathway, and silenced SERPINB2 in vivo effectively promotes fracture healing, suggesting that SERPINB2 may be a novel target for bone fracture healing.PMID:34620242 | DOI:10.1186/s13287-021-02581-6
Source: Cell Research - October 8, 2021 Category: Cytology Authors: Kai Hang Li Ying Jinwu Bai Yibo Wang Zhihui Kuang Deting Xue Zhijun Pan Source Type: research

Therapeutic effects of human monoclonal PSMA antibody-mediated TRIM24 siRNA delivery in PSMA-positive castration-resistant prostate cancer
Conclusion: PSMAb mediated TRIM24 siRNA delivery platform could significantly inhibit cell proliferation, colony-formation, and invasion in PSMA+ CRPC in vitro and suppressed tumor growth and bone loss in PSMA+ CRPC xenograft and bone metastasis model.
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Sheng-Jia Shi, Li-Juan Wang, Dong-Hui Han, Jie-Heng Wu, Dian Jiao, Kai-Liang Zhang, Jiang-Wei Chen, Yu Li, Fa Yang, Jing-Liang Zhang, Guo-Xu Zheng, An-Gang Yang, Ai-Zhi Zhao, Wei-Jun Qin, Wei-Hong Wen Tags: Research Paper Source Type: research

RNA-Seq revealed ATF3-regulated inflammation induced by silica.
CONCLUSION: This indicated that ATF3 may be a potential early diagnostic biomarker for silicosis and ATF3 acts as a repressor in inflammatory responses induced by silica. PMID: 29102675 [PubMed - as supplied by publisher]
Source: Toxicology - November 1, 2017 Category: Toxicology Authors: Chan JYW, Tsui JCC, Law PTW, So WKW, Leung DYP, Sham MMK, Tsui SKW, Chan CWH Tags: Toxicology Source Type: research

Improving the osteogenic efficacy of BMP2 with mechano growth factor by regulating the signaling events in BMP pathway
Abstract Local application of bone morphogenetic protein 2 (BMP2) is known to promote large bone defect healing and BMP2-initiated bone regeneration could be enhanced by an additional mechanical stimulation. The C-terminal 24-a.a. peptide of mechano growth factor (MGF24E), a mechanical-sensitive molecule, has been demonstrated to promote bone healing. Here, we propose a hypothesis that MGF24E could also improve the osteogenic efficacy of BMP2 by regulating the signaling events in the BMP pathway. To confirm the hypothesis, the potentials of MGF24E, BMP2 and BMP2/MGF24E combination treatments on the phosphorylation...
Source: Cell and Tissue Research - April 7, 2015 Category: Cytology Source Type: research