Knockdown of SERPINB2 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the Wnt/ β-catenin signalling pathway

CONCLUSIONS: Taken together, these findings indicate that SERPINB2 silencing promoted osteogenic differentiation of BMSCs via the Wnt/β-catenin signaling pathway, and silenced SERPINB2 in vivo effectively promotes fracture healing, suggesting that SERPINB2 may be a novel target for bone fracture healing.PMID:34620242 | DOI:10.1186/s13287-021-02581-6

Source: Cell Research - October 8, 2021 Category: Cytology Authors: Kai Hang Li Ying Jinwu Bai Yibo Wang Zhihui Kuang Deting Xue Zhijun Pan Source Type: research