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Drug: Melatonin
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Total 136 results found since Jan 2013.
Melatonin MT < sub > 2 < /sub > receptor is expressed and potentiates contraction in human airway smooth muscle
Am J Physiol Lung Cell Mol Physiol. 2021 Oct 6. doi: 10.1152/ajplung.00273.2021. Online ahead of print.ABSTRACTNocturnal asthma is characterized by heightened bronchial reactivity at night, and plasma melatonin concentrations are higher in patients with nocturnal asthma symptoms. Numerous physiological effects of melatonin are mediated via its specific G protein-coupled receptors (GPCRs) named the MT1 receptor which couples to both Gq and Gi proteins, and the MT2 receptor which couples to Gi. We investigated whether melatonin receptors are expressed on airway smooth muscle, whether they regulate intracellular cyclic AMP (c...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - October 6, 2021 Category: Cytology Authors: Haruka Sasaki Yi Zhang Charles W Emala Kentaro Mizuta Source Type: research
Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation
J Pineal Res. 2021 Nov 26:e12781. doi: 10.1111/jpi.12781. Online ahead of print.ABSTRACTMelatonin, secreted by the pineal gland, regulates the circadian rhythms and also plays an oncostatic roles in cancer cells. Previously, we showed that melatonin induced the expression of Bim, a pro-apoptotic Bcl-2 protein, at both the transcriptional and post-translational levels. In the present study, we investigated the molecular mechanisms underlying the melatonin-mediated Bim upregulation through post-translational regulation. We found that ovarian tumor domain-containing protein 1 (OTUD1), a deubiquitinase belonging to the OTU pro...
Source: Cell Research - November 26, 2021 Category: Cytology Authors: Seon Min Woo Seung Un Seo Kyoung-Jin Min Taeg Kyu Kwon Source Type: research
Valsartan- and melatonin-supported adipose-derived mesenchymal stem cells preserve renal function in chronic kidney disease rat through upregulation of prion protein participated in promoting PI3K-Akt-mTOR signaling and cell proliferation
In conclusion, Mel/Val facilitated-ADMSCs preserved renal architecture and function in CKD rat through promoting PrPC to regulate the cell proliferation/oxidative-stress/cell-stress signalings.PMID:34923336 | DOI:10.1016/j.biopha.2021.112551
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 19, 2021 Category: Drugs & Pharmacology Authors: Chih-Chao Yang Pei-Hsun Sung Kuan-Hung Chen Han-Tan Chai John Y Chiang Sheung-Fat Ko Fan-Yen Lee Hon-Kan Yip Source Type: research
Melatonin alleviates doxorubicin-induced mitochondrial oxidative damage and ferroptosis in cardiomyocytes by regulating YAP expression
In this study, we established a Dox-induced cardiotoxicity model in H9c2 cardiomyocytes, zebrafish, and SD rats to explore the mechanism by which Mel alleviates Dox-induced cardiotoxicity. In vivo and in vitro experiments showed that Dox significantly decreased the viability of H9c2 cells, induced apoptosis, myocardial injury, and effectively up-regulated the expression of p-YAP but down-regulated the expression of YAP. Furthermore, we found that Dox significantly up-regulated the expression of ferroptosis-associated protein ACSL4 and down-regulated expression of GPX4. Interestingly, these effects of Dox were reversed foll...
Source: Toxicology and Applied Pharmacology - January 30, 2022 Category: Toxicology Authors: Xiao Sun Ping Sun Dong Zhen Xiangli Xu Li Yang Danni Fu Chengxi Wei Xiaofeng Niu Jiawei Tian Hairu Li Source Type: research
Copolymer micelle-administered melatonin ameliorates hyperosmolarity-induced ocular surface damage through regulating PINK1 mediated mitophagy
CONCLUSIONS: Our findings demonstrated that Mel-Mic ameliorates hyperosmolarity induced ocular surface damage via PINK1 mediated mitophagy and may represent an effective treatment for DED possibly through acting MT1 receptor.PMID:35179400 | DOI:10.1080/02713683.2021.2022163
Source: Current Eye Research - February 18, 2022 Category: Opthalmology Authors: Jing Xu Peng Chen Guangfen Zhao Susu Wei Qiqi Li Chuanlong Guo Qilong Cao Xianggen Wu Guohu Di Source Type: research
Melatonin inhibits angiotensin II-induced atrial fibrillation through preventing degradation of Ang II Type I Receptor-Associated Protein (ATRAP)
In this study, Ang II was used to induce AF, and AF inducibility and duration were documented telemetrically. Ang II-infused mice had a higher AF incidence, which was associated with atrial fibrosis, inflammation, and oxidative stress. Melatonin partially inhibited these effects, and enforced expression of siRNA-ATRAP in atria counteracted the beneficial role of melatonin. Specifically, melatonin inhibited expression of Ang II-induced proteasome and immunoproteasome subunits β2, β2i, β5, and β5i as well as their corresponding trypsin-like and chymotrypsin-like activities and blocked ATRAP degradation. In turn, this inh...
Source: Biochemical Pharmacology - June 16, 2022 Category: Drugs & Pharmacology Authors: Xin Xie Ting-Ting Shen Hai-Lian Bi Zhuo-Lin Su Zi-Qi Liao Ying Zhang Lei Shi Yun-Long Xia Source Type: research
Melatonin attenuates MPP < sup > + < /sup > -induced apoptosis via heat shock protein in a Parkinson's disease model
Biochem Biophys Res Commun. 2022 Jul 1;621:59-66. doi: 10.1016/j.bbrc.2022.06.099. Online ahead of print.ABSTRACTHeat shock proteins (HSPs) play an essential role as molecular chaperones to prevent abnormal protein aggregation and misfolding. Moreover, they protect dopamine neurons from oxidative stress, inflammation, and apoptosis, all well-known pathomechanisms of Parkinson's disease (PD). Melatonin is a potent antioxidant that has the beneficial ability to prevent neurodegenerative diseases like PD. We aimed to explore the protective properties of melatonin in an in vitro PD model, focusing on its underlying mechanism u...
Source: Biochemical and Biophysical Research communications - July 10, 2022 Category: Biochemistry Authors: Yu Jin Jung Hyunsu Choi Eungseok Oh Source Type: research
