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Drug: Melatonin
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Total 136 results found since Jan 2013.
Melatonin attenuates methamphetamine-induced neuroinflammation through the melatonin receptor in the SH-SY5Y cell line.
In this study, we investigated the effect of methamphetamine on TNFα expression and NFκB activation in the neuroblastoma cell line SH-SY5Y. We demonstrated the time-dependent effect of methamphetamine on the induction of TNFα expression as well as IκB degradation and NFκB nuclear translocation. Furthermore, we investigated the effect of melatonin on methamphetamine-induced TNFα overexpression and NFκB activation. The results showed that pretreatment with 100nM melatonin could prevent the TNFα overexpression caused by methamphetamine exposure. This attenuating effect was prevented by pre-incubation with luzindole, a...
Source: Neurotoxicology - August 14, 2015 Category: Neurology Authors: Wongprayoon P, Govitrapong P Tags: Neurotoxicology Source Type: research
Reduced SIRT1 signaling exacerbates myocardial ischemia reperfusion injury in type 2 diabetic rats and the protective effect of melatonin
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - August 20, 2015 Category: Research Authors: Liming Yu, Hongliang Liang, Xiaochao Dong, Guolong Zhao, Zhenxiao Jin, Mengen Zhai, Yang Yang, Wensheng Chen, Jincheng Liu, Wei Yi, Jian Yang, Dinghua Yi, Weixun Duan, Shiqiang Yu Tags: Original Article Source Type: research
Reduced silent information regulator 1 signaling exacerbates myocardial ischemia–reperfusion injury in type 2 diabetic rats and the protective effect of melatonin
In this study, we developed high‐fat diet‐fed streptozotocin (HFD‐STZ) rat, a well‐known type 2 diabetic model, to evaluate the effect of melatonin on MI/R injury with a focus on silent information regulator 1 (SIRT1) signaling, oxidative stress, and PERK/eIF2α/ATF4‐mediated ER stress. HFD‐STZ treated rats were exposed to melatonin treatment in the presence or the absence of sirtinol (a SIRT1 inhibitor) and subjected to MI/R surgery. Compared with nondiabetic animals, type 2 diabetic rats exhibited significantly decreased myocardial SIRT1 signaling, increased apoptosis, enhanced oxidative stress, and ER stress...
Source: Journal of Pineal Research - September 11, 2015 Category: Research Authors: Liming Yu, Hongliang Liang, Xiaochao Dong, Guolong Zhao, Zhenxiao Jin, Mengen Zhai, Yang Yang, Wensheng Chen, Jincheng Liu, Wei Yi, Jian Yang, Dinghua Yi, Weixun Duan, Shiqiang Yu Tags: Original Article Source Type: research
Melatonin antagonizes cadmium‐induced neurotoxicity by activating the transcription factor EB ‐dependent autophagy‐lysosome machinery in mouse neuroblastoma cells
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - July 11, 2016 Category: Research Authors: Min Li, Huifeng Pi, Zhiqi Yang, Russel J. Reiter, Shangcheng Xu, Xiaowei Chen, Chunhai Chen, Lei Zhang, Yang Min, Yuming Li, Pan Guo, Gaoming Li, Manyu Tu, Li Tian, Jia Xie, Mindi He, Yonghui Lu, Min Zhong, Yanwen Zhang, Zhengping Yu, Zhou Zhou Tags: Original Article Source Type: research
Melatonin antagonizes cadmium ‐induced neurotoxicity by activating the transcription factor EB ‐dependent autophagy‐lysosome machinery in mouse neuroblastoma cells
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - July 9, 2016 Category: Research Authors: Min Li, Huifeng Pi, Zhiqi Yang, Russel J. Reiter, Shangcheng Xu, Xiaowei Chen, Chunhai Chen, Lei Zhang, Yang Min, Yuming Li, Pan Guo, Gaoming Li, Manyu Tu, Li Tian, Jia Xie, Mindi He, Yonghui Lu, Min Zhong, Yanwen Zhang, Zhengping Yu, Zhou Zhou Tags: Original Article Source Type: research
Melatonin ‐induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - August 1, 2016 Category: Research Authors: N éstor Prieto‐Domínguez, Raquel Ordóñez, Anna Fernández, Carolina Méndez‐Blanco, Anna Baulies, Carmen Garcia‐Ruiz, José C. Fernández‐Checa, José L. Mauriz, Javier González‐Gallego Tags: Original Article Source Type: research
Melatonin antagonizes cadmium ‐induced neurotoxicity by activating the transcription factor EB‐dependent autophagy–lysosome machinery in mouse neuroblastoma cells
Abstract
Cadmium (Cd), a highly ubiquitous heavy metal, induces neurotoxicity. Melatonin, a major secretory product of the pineal gland, protects against Cd‐induced neurotoxicity. However, the mechanism that accounts for this protection remains to be elucidated. Herein, we exposed mouse neuroblastoma cells (Neuro‐2a cells) to different concentrations of cadmium chloride (CdCl2) (12.5, 25, and 50 μ mol L−1) for 24 hours. We showed that Cd inhibits autophagosome–lysosome fusion and impairs lysosomal function, subsequently leading to nerve cell death. In addition, Cd decreases the level of transcription factor EB...
Source: Journal of Pineal Research - August 2, 2016 Category: Research Authors: Min Li, Huifeng Pi, Zhiqi Yang, Russel J. Reiter, Shangcheng Xu, Xiaowei Chen, Chunhai Chen, Lei Zhang, Min Yang, Yuming Li, Pan Guo, Gaoming Li, Manyu Tu, Li Tian, Jia Xie, Mindi He, Yonghui Lu, Min Zhong, Yanwen Zhang, Zhengping Yu, Zhou Zhou Tags: Original Article Source Type: research
Melatonin alleviates cadmium ‐induced liver injury by inhibiting the TXNIP‐NLRP3 inflammasome
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - January 17, 2017 Category: Research Authors: Zhengwang Cao, Yiliang Fang, Yonghui Lu, Dunxian Tan, Changhong Du, Yuming Li, Qinlong Ma, Junmei Yu, Mengyan Chen, Chao Zhou, Liping Pei, Lei Zhang, Haiying Ran, Mindi He, Zhengping Yu, Zhou Zhou Tags: Original Article Source Type: research
Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation.
CONCLUSION: These findings indicate that melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis.
PMID: 28246472 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - February 13, 2017 Category: Gastroenterology Authors: Bu LJ, Yu HQ, Fan LL, Li XQ, Wang F, Liu JT, Zhong F, Zhang CJ, Wei W, Wang H, Sun GP Tags: World J Gastroenterol Source Type: research
Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3 ‐dependent regulation of oxidative stress and apoptosis
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - May 13, 2017 Category: Research Authors: Mengen Zhai, Buying Li, Weixun Duan, Lin Jing, Bin Zhang, Meng Zhang, Liming Yu, Zhenhua Liu, Bo Yu, Kai Ren, Erhe Gao, Yang Yang, Hongliang Liang, Zhenxiao Jin, Shiqiang Yu Tags: Original Article Source Type: research
Melatonin synthesis in the human ciliary body triggered by TRPV4 activation: Involvement of AANAT phosphorylation.
In conclusion, the activation of calmodulin and calmodulin-dependent protein kinase II was confirmed, as shown by the cascade seen in AANAT phosphorylation (***p < 0.001, n = 4). This mechanism was also established by measuring N-acetyl serotonin and melatonin levels. In conclusion, the activation of a TRPV4 present in human ciliary body epithelial cells produced an increase in AANAT phosphorylation and a further melatonin increase by a mechanism in which Ca-calmodulin and the calmodulin-dependent protein kinase II are involved.
PMID: 28655604 [PubMed - as supplied by publisher]
Source: Experimental Eye Research - June 24, 2017 Category: Opthalmology Authors: Alkozi HA, Perez de Lara MJ, Pintor J Tags: Exp Eye Res Source Type: research
Melatonin protects chondrocytes from impairment induced by glucocorticoids via NAD+-dependent SIRT1
Publication date: Available online 10 August 2017 Source:Steroids Author(s): Wei Yang, Xiaomin Kang, Na Qin, Feng Li, Xinxin Jin, Zhengmin Ma, Zhuang Qian, Shufang Wu Intra-articular injection of glucocorticoids is used to relieve pain and inflammation in osteoarthritis patients, which is occasionally accompanied with the serious side effects of glucocorticoids in collagen-producing tissue. Melatonin is the major hormone released from the pineal gland and its beneficial effects on cartilage has been suggested. In the present study, we investigated the protective role of melatonin on matrix degeneration in chondrocytes ind...
Source: Steroids - August 10, 2017 Category: Drugs & Pharmacology Source Type: research
Melatonin protects diabetic heart against ischemia-reperfusion injury, role of membrane receptor-dependent cGMP-PKG activation
This study was designed to determine the role of melatonin membrane receptors in melatonin's cardioprotective actions against diabetic MI/R injury with a focus on cGMP and its downstream effector PKG. Streptozotocin-induced diabetic Sprague-Dawley rats and high-glucose medium-incubated H9c2 cardiomyoblasts were utilized to determine the effects of melatonin against MI/R injury. Melatonin treatment preserved cardiac function and reduced oxidative damage and apoptosis. Additionally, melatonin increased intracellular cGMP level, PKGIα expression, p-VASP/VASP ratio and further modulated myocardial Nrf-2-HO-1 and MAPK signalin...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - December 6, 2017 Category: Molecular Biology Source Type: research
TMEM16A and TMEM16B channel proteins generate Ca2+-activated Cl- current and regulate melatonin secretion in rat pineal glands Cell Biology
In conclusion, pineal ClCa channels are composed of TMEM16A and TMEM16B subunits, and these fluxes regulate melatonin secretion in pineal glands.
Source: Journal of Biological Chemistry - January 19, 2018 Category: Chemistry Authors: Hisao Yamamura, Kaori Nishimura, Yumiko Hagihara, Yoshiaki Suzuki, Yuji Imaizumi Tags: Membrane Biology Source Type: research
Melatonin protects against myocardial ischemia-reperfusion injury by elevating Sirtuin3 expression and manganese superoxide dismutase activity.
Authors: Feng J, Chen X, Liu R, Cao C, Zhang W, Zhao Y, Nie S
Abstract
Myocardial ischemia-reperfusion (MI/R) injury is a crucial cause for mortality throughout the world. Recent studies indicated that melatonin might exert profound cardio-protective effect in MI/R injury. However, the underlying mechanisms are not completely understood. In the current study, we aimed to explore the potential effect of melatonin in the pathological process of MI/R. Both in vivo MI/R model and in vitro H9c2 cell line simulated I/R (SIR) model were applied with or without melatonin supplementation. We found that Sirtuin3 (Sirt3) expr...
Source: Free Radical Research - September 15, 2018 Category: Research Tags: Free Radic Res Source Type: research
