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Drug: Melatonin
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Total 136 results found since Jan 2013.
Melatonin attenuates MPP < sup > + < /sup > -induced apoptosis via heat shock protein in a Parkinson's disease model
Biochem Biophys Res Commun. 2022 Jul 1;621:59-66. doi: 10.1016/j.bbrc.2022.06.099. Online ahead of print.ABSTRACTHeat shock proteins (HSPs) play an essential role as molecular chaperones to prevent abnormal protein aggregation and misfolding. Moreover, they protect dopamine neurons from oxidative stress, inflammation, and apoptosis, all well-known pathomechanisms of Parkinson's disease (PD). Melatonin is a potent antioxidant that has the beneficial ability to prevent neurodegenerative diseases like PD. We aimed to explore the protective properties of melatonin in an in vitro PD model, focusing on its underlying mechanism u...
Source: Biochemical and Biophysical Research communications - July 10, 2022 Category: Biochemistry Authors: Yu Jin Jung Hyunsu Choi Eungseok Oh Source Type: research
Melatonin ameliorates diabetic hyperglycaemia-induced impairment of Leydig cell steroidogenic function through activation of SIRT1 pathway
CONCLUSIONS: These findings suggest that SIRT1 pathway plays essential roles in the pleiotropic actions of melatonin on Leydig cells and in the prevention of hyperglycaemia-induced steroidogenic dysfunction. The stimulatory action of melatonin on SIRT1 pathway is related to oxidative stress and its antioxidant property. Our data provide new evidence for the relationship of melatonin and SIRT1 pathway in the context of hyperglycaemia, and melatonin as a combination therapy may be useful to combat DM-related complications, especially male reproductive system injury.PMID:35962432 | DOI:10.1186/s12958-022-00991-6
Source: Reproductive Biology - August 12, 2022 Category: Reproduction Medicine Authors: Ping Wang Shoubing Zhang Shuai Lin Zhengmei Lv Source Type: research
Melatonin Sensitizes OVCAR-3 Cells to Cisplatin through Suppression of PI3K/Akt Pathway
This study examined the effect of melatonin on oxidative stress, expression of pro-apoptotic protein, anti-apoptotic proteins, and the activity of the PI3K/Akt signaling pathway in the human ovarian cancer cell line (OVCAR3). OVCAR3 cells were treated with cisplatin, melatonin, cisplatin + melatonin, and siRNA Akt. Reactive oxygen species levels were assessed. The expression of the proteins was determined by Western blot. Melatonin administration significantly increased intracellular ROS generation, the cleavage of caspase 3 and decreased phosphorylation of Akt. Combination therapy of cisplatin and melatonin increases apop...
Source: Mol Biol Cell - August 21, 2022 Category: Molecular Biology Authors: Sahar Baghal-Sadriforoush Morteza Bagheri Isa Abdi Rad Fattah Sotoodehnejadnematalahi Source Type: research
Melatonin activates the Mst1-Nrf2 signaling to alleviate cardiac hypertrophy in pulmonary arterial hypertension
This study aims to suggest one such possible treatment, through investigating the cardio-protective capabilities of the anti-oxidant, melatonin (Mel), for treating adverse RV remodeling in PAH, along with its underlying mechanisms. Arginine vasopressin induced neonatal rat cardiomyocyte hypertrophy in vitro; in vivo, PAH was induced in rats through intraperitoneal monocrotaline (MCT) injections, and Mel was administered intraperitoneally 24 h prior to MCT. Mel reduced rat cardiomyocyte hypertrophy and mitochondrial oxidative stress in vitro by activating the Mst1-Nrf2 pathway, which were all reversed upon siRNA knockdown o...
Source: European Journal of Pharmacology - September 13, 2022 Category: Drugs & Pharmacology Authors: Shuang Chen Ping Sun You Li Wenqian Shen Chao Wang Peng Zhao Hao Cui Jing-Yi Xue Guo-Qing Du Source Type: research
Melatonin alleviates arginine vasopressin-induced cardiomyocyte apoptosis via increasing Mst1-Nrf2 pathway activity to reduce oxidative stress
In this study, high AVP doses were found to induce H9c2 cardiomyoblast apoptosis, demonstrated by increased terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells, pro-apoptotic B-cell lymphoma-2 (Bcl-2)-associated X protein (Bax) up-regulation, and anti-apoptotic Bcl-2 downregulation. This AVP-induced apoptotic increase, along with lowered cell viability, was also associated with higher reactive oxygen species (ROS) levels and lowered mitochondrial membrane potentials (MMP), which were all reversed upon Mel administration. Further investigations found that apoptosis, ROS, and MMP outcomes unde...
Source: Biochemical Pharmacology - October 2, 2022 Category: Drugs & Pharmacology Authors: Shuang Chen You Li Shuai Fu Yang Li Chao Wang Ping Sun Hairu Li Jiawei Tian Guo-Qing Du Source Type: research
Melatonin Protects Against Hyperoxia-Induced Apoptosis in Alveolar Epithelial type II Cells by Activating the MT2/PI3K/AKT/ETS1 Signaling Pathway
ConclusionMelatonin prevents hyperoxia-induced apoptosis by activating the MT2/PI3K/AKT/ETS1 axis in alveolar epithelial cells.
Source: Lung - March 17, 2023 Category: Respiratory Medicine Source Type: research
