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Condition: Osteoarthritis
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Total 352 results found since Jan 2013.
BNIP3 mediates the different adaptive responses of fibroblast-like synovial cells to hypoxia in patients with osteoarthritis and rheumatoid arthritis
CONCLUSION: In summary, RA-FLSs maintained intracellular redox balance through mitophagy to promote cell survival under hypoxia. The mitophagy of OA-FLSs was too little to maintain the redox balance of mitochondria, resulting in apoptosis. The difference of mitophagy between OA-FLSs and RA-FLSs under hypoxia is mediated by the level of BNIP3 expression.PMID:35690741 | DOI:10.1186/s10020-022-00490-9
Source: Molecular Medicine - June 11, 2022 Category: Molecular Biology Authors: Ran Deng Yan Wang Yanhong Bu Hong Wu Source Type: research
High TRB3 expression induces chondrocyte autophagy and senescence in osteoarthritis cartilage
CONCLUSIONS: Interfering with TRB3 expression in cartilage may serve as a target in the prevention and treatment of age-related osteoarthritis.PMID:35776529 | DOI:10.18632/aging.204066
Source: Aging - July 1, 2022 Category: Biomedical Science Authors: Yanqing Gu Ren Yan Yang Wang Yiwen Zeng Qingqiang Yao Source Type: research
Contribution of microRNA ‐27b‐3p to synovial fibrotic responses in knee osteoarthritis
ConclusionsThis study demonstrates a key role of miR-27b-3p in ECM regulation associated with synovial fibrosis during OA.
Source: Arthritis and Rheumatology - July 6, 2022 Category: Rheumatology Authors: Ghazaleh Tavallaee,
Starlee Lively,
Jason S. Rockel,
Shabana Amanda Ali,
Michelle Im,
Clementine Sarda,
Greniqueca M. Mitchell,
Evgeny Rossomacha,
Sayaka Nakamura,
Pratibha Potla,
Sarah Gabrial,
John Matelski,
Anusha Ratneswaran,
Kim Perry,
Tags: Full Length Source Type: research
Network Pharmacology-Based Strategy to Investigate the Mechanisms of < em > Cibotium barometz < /em > in Treating Osteoarthritis
Evid Based Complement Alternat Med. 2022 Jul 14;2022:1826299. doi: 10.1155/2022/1826299. eCollection 2022.ABSTRACTCibotium barometz is a representative tonifying kidney drug and is widely used for osteoarthritis (OA) in traditional Chinese medicine. However, its regulatory mechanisms in treating OA remain to be sufficiently investigated. The main chemical components of Cibotium barometz were screened through the TCMID database and the corresponding targets were acquired through SwissTargetPrediction. The OA-related targets were obtained from the OMIM, Genecards, Genebank, TTD, and DisGeNET databases. The prediction of key ...
Source: Evidence-based Complementary and Alternative Medicine - July 25, 2022 Category: Complementary Medicine Authors: Guang-Yao Chen Yi-Fei Wang Xin-Bo Yu Xiao-Yu Liu Jia-Qi Chen Jing Luo Qing-Wen Tao Source Type: research
Inhibition of GAB2 expression has a protective effect on osteoarthritis:An in vitro and in vivo study
In conclusion, our study demonstrates that GAB2 is a potential therapeutic target for OA.PMID:36007472 | DOI:10.1016/j.bbrc.2022.08.006
Source: Biochemical and Biophysical Research communications - August 25, 2022 Category: Biochemistry Authors: Haokun Mo Siying Yang An-Min Chen Source Type: research
Chondroitin sulfate modified chitosan nanoparticles as an efficient and targeted gene delivery vehicle to chondrocytes
In conclusion, CH-CS nanoparticles can be considered as a candidate for gene therapy purposes in cartilage diseases.PMID:36049252 | DOI:10.1016/j.colsurfb.2022.112786
Source: Colloids and Surfaces - September 1, 2022 Category: Biotechnology Authors: Naghmeh Akbari Moghadam Fatemeh Bagheri Mohamadreza Baghaban Eslaminejad Source Type: research
Stabilization of hypoxia-inducible factor-1 α alleviates osteoarthritis via interacting with Per2 and resetting the circadian clock
CONCLUSIONS: This study shows that circadian clock resetting caused by DMOG is at least partially mediated by the HIF1α through interaction with the Per2 promoter and proposes DMOG as supportive therapy for OA.PMID:36162153 | DOI:10.1016/j.tice.2022.101942
Source: Tissue and Cell - September 26, 2022 Category: Cytology Authors: Chenzhong Wang Yueqi Zhang Zhe Wang Wei Yu Minji Tong Zuoqin Yan Source Type: research
