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Vitamin D/vitamin D receptor/Atg16L1  axis maintains podocyte autophagy and survival in diabetic kidney disease
CONCLUSION: Autophagy protects podocytes from damage in DN and is modulated by VitD3/VDR signaling and downstream regulation of Atg16L1 expression.PMID:35469547 | DOI:10.1080/0886022X.2022.2063744
Source: Renal Failure - April 26, 2022 Category: Urology & Nephrology Authors: Lang Shi Chao Xiao Yafei Zhang Yao Xia Hongchu Zha Jiefu Zhu Zhixia Song Source Type: research

CCAAT/Enhancer-Binding Protein Alpha Is a Novel Regulator of Vascular Smooth Muscle Cell Osteochondrogenic Transition and Vascular Calcification
CONCLUSION: Findings in this study indicate that C/EBPα is a key regulator of the osteochondrogenic transdifferentiation of VSMCs and vascular calcification, which may represent a novel therapeutic target for vascular calcification.PMID:35295585 | PMC:PMC8918665 | DOI:10.3389/fphys.2022.755371
Source: Atherosclerosis - March 17, 2022 Category: Cardiology Authors: Pengyuan Chen Wanzi Hong Ziying Chen Flora Gordillo-Martinez Siying Wang Hualin Fan Yuanhui Liu Yining Dai Bo Wang Lei Jiang Hongjiao Yu PengCheng He Source Type: research

Tanshinone IIA attenuates high glucose-induced epithelial-to-mesenchymal transition in HK-2 cells through VDR/Wnt/ β-catenin signaling pathway
CONCLUSIONS: TSIIA was able to attenuate high glucose-induced EMT in HK2 cells by up-regulating VDR levels, which might be related to the inhibitory effect of VDR on the Wnt pathway.PMID:34852178 | DOI:10.5603/FHC.a2021.0025
Source: Folia Histochemica et Cytobiologica - December 1, 2021 Category: Cytology Authors: Jingyi Zeng Xiaorong Bao Source Type: research

Vitamin D protects glomerular mesangial cells from high glucose-induced injury by repressing JAK/STAT signaling
ConclusionVitamin D (VD) treatment inhibits the function of HG on fibronectin production through regulating JAK/STAT pathway. These results provide direct evidences that VD protects glomerular mesangial cells from high glucose-induced injury through repressing JAK/STAT signaling, which has the potential for clinical DN treatment.
Source: International Urology and Nephrology - May 3, 2021 Category: Urology & Nephrology Source Type: research

Leading RNA Interference Therapeutics Part 1: Silencing Hereditary Transthyretin Amyloidosis, with a Focus on Patisiran
AbstractIn 2018, patisiran was the first-ever RNA interference (RNAi)-based drug approved by the US Food and Drug Administration. Now pharmacology textbooks may include a new drug class that  results in the effect first described by Fire and Mello 2 decades ago: post-transcriptional gene silencing by a small-interfering RNA (siRNA). Patients with hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis) present with mutations in the transthyretin (TTR) gene that lead to the formation of amyloid deposits in peripheral nerves and heart. The disease may also affect the eye and central nervous system. The formulatio...
Source: Molecular Diagnosis and Therapy - November 6, 2019 Category: Molecular Biology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Vitamin D suppresses macrophage infiltration by down-regulation of TREM-1 in diabetic nephropathy rats
This study intends to investigate the effect of active vitamin D (VD) on the expression of triggering receptor expressed on myeloid cells-1 (TREM-1) in the renal tissues of diabetic nephropathy (DN) rats and to explore the impact of TREM-1 on macrophage adhesion and migration. We find that the expressions of TREM-1 and CD68 protein are higher in DN rats compared with rats in the normal control group and that these changes are decreased in the DN + VD group. In vitro, the capacity for macrophage adhesion and migration and the expression of TREM-1 are increased under high-glucose conditions, but VD inhibits this progress....
Source: Molecular and Cellular Endocrinology - July 10, 2018 Category: Endocrinology Source Type: research

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