Filtered By:
Nutrition: Flavonoids

This page shows you your search results in order of date. This is page number 4.

Order by Relevance | Date

Total 111 results found since Jan 2013.

Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NADFormula: see text-CD38 Axis
In this study, we selected the hydrogen peroxide (H2O[Formula: see text]- or doxorubicin (DOXO)-induced senescence model in WI-38 human embryonic lung fibroblast cells to determine the potential anti-aging effects of apigenin in vitro and associated molecular mechanisms. We found that apigenin reduced senescence-associated [Formula: see text]-galactosidase (SA-[Formula: see text]-gal) activity and promoted cell growth, concomitant with a decrease in levels of Acetyl (ac)-p53, p21[Formula: see text], and p16[Formula: see text] and an increase in phospho (p)-Rb. Apigenin also increased the activation ratio of silent informat...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Bing Si Li Ri Zhe Zhu Seok-Hee Lim Jae Ho Seo Byung-Min Choi Source Type: research

Total Flavonoids of Rhizoma Drynariae Restore the MMP/TIMP Balance in Models of Osteoarthritis by Inhibiting the Activation of the NF- < em > κB < /em > and PI3K/AKT Pathways
In conclusion, TFRD showed chondroprotective effects by restoring the MMP/TIMP balance in OA models by suppressing the activation of the NF-κB and PI3K/AKT pathways.PMID:33995548 | PMC:PMC8081598 | DOI:10.1155/2021/6634837
Source: Evidence-based Complementary and Alternative Medicine - May 17, 2021 Category: Complementary Medicine Authors: Guang-Yao Chen Jia-Qi Chen Xiao-Yu Liu Yuan Xu Jing Luo Yi-Fei Wang Tong-Liang Zhou Ze-Ran Yan Li Zhou Qing-Wen Tao Source Type: research

(-)-Epicatechin acts as a potent agonist of the membrane androgen receptor, ZIP9 (SLC39A9), to promote apoptosis of breast and prostate cancer cells
J Steroid Biochem Mol Biol. 2021 May 11:105906. doi: 10.1016/j.jsbmb.2021.105906. Online ahead of print.ABSTRACT(-)-Epicatechin, a flavonoid present in high concentrations in foods such as green tea and cocoa, exerts beneficial and protective effects in numerous disease models, including anti-tumorigenesis and apoptosis in human breast and prostate cancer cells. Potential interactions of (-)-epicatechin and (+)-catechin with the membrane androgen receptor, ZIP9 (SLC39A9), which mediates androgen induction of apoptosis in these cancer cells, were investigated. Both (-)-epicatechin and (+)-catechin were effective competitors...
Source: Mol Biol Cell - May 14, 2021 Category: Molecular Biology Authors: Peter Thomas Jing Dong Source Type: research

Quercetin alleviates chronic unpredictable mild stress-induced depressive-like behaviors by promoting adult hippocampal neurogenesis via FoxG1/CREB/ BDNF signaling pathway
In this study, we explored whether quercetin plays an anti-depressant role via regulation of FoxG1 signaling in mice and revealed the potential mechanisms. To explore the antidepressant effects of quercetin, mice were subjected to behavioral tests after a chronic unpredictable mild stress (CUMS) exposure. We found that chronic quercetin treatment (15 mg/kg, 30 mg/kg) obviously restored the weight loss of mice caused by CUMS and alleviated CUMS-induced depression-like behaviors, such as increased sucrose consumption, improved locomotor activity and shorten immobility time. In addition, to clarify the relationship between qu...
Source: Behavioural Brain Research - March 22, 2021 Category: Neurology Authors: Zhong-Xuan Ma Ru-Yi Zhang Wen-Juan Rui Zhi-Qing Wang None Xia-Feng Source Type: research

Quercetin induces pro ‐apoptotic autophagy via SIRT1/AMPK signaling pathway in human lung cancer cell lines A549 and H1299 in vitro
ConclusionsQuercetin ‐induced autophagy contributes to apoptosis in A549 and H1299 lung cancer cells, which involved the SIRT1/AMPK signaling pathway.
Source: Thoracic Cancer - March 12, 2021 Category: Cancer & Oncology Authors: Hengjuan Guo, Hui Ding, Xin Tang, Maoli Liang, Shuo Li, Jing Zhang, Jie Cao Tags: ORIGINAL ARTICLE Source Type: research

Quercetin reverses TNF ‑α induced osteogenic damage to human periodontal ligament stem cells by suppressing the NF‑κB/NLRP3 inflammasome pathway.
Quercetin reverses TNF‑α induced osteogenic damage to human periodontal ligament stem cells by suppressing the NF‑κB/NLRP3 inflammasome pathway. Int J Mol Med. 2021 Apr;47(4): Authors: Zhang W, Jia L, Zhao B, Xiong Y, Wang YN, Liang J, Xu X Abstract Quercetin (Quer) is a typical antioxidant flavonoid from plants that is involved in bone metabolism, as well as in the progression of inflammatory diseases. Elevated levels of tumor necrosis factor‑α (TNF‑α), a typical pro‑inflammatory cytokine, can affect osteogenesis. In the present study, TNF‑α was used to establish an in vitro model o...
Source: International Journal of Molecular Medicine - February 6, 2021 Category: Molecular Biology Authors: Zhang W, Jia L, Zhao B, Xiong Y, Wang YN, Liang J, Xu X Tags: Int J Mol Med Source Type: research

Hesperetin protects against palmitate-induced cellular toxicity via induction of GRP78 in hepatocytes.
In conclusion, hesperetin protected against palmitate-induced hepatic cell death via activation of the sXBP1/GRP78 signaling pathway, thus inhibiting palmitate-induced ER stress. Moreover, high concentrations of hesperetin induce ER stress and subsequently cause cell death in hepatocytes. PMID: 32763355 [PubMed - as supplied by publisher]
Source: Toxicology and Applied Pharmacology - August 4, 2020 Category: Toxicology Authors: Geng Y, Wu Z, Buist-Homan M, Blokzijl H, Moshage H Tags: Toxicol Appl Pharmacol Source Type: research