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Nutrition: Flavonoids

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Total 111 results found since Jan 2013.

Dihydromyricetin inhibits NLRP3 inflammasome ‐dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cells
Abstract Increasing evidence demonstrates that pyroptosis, pro‐inflammatory programmed cell death, is linked to atherosclerosis; however, the underlying mechanisms remain to be elucidated. Dihydromyricetin (DHM), a natural flavonoid, was reported to exert anti‐oxidative and anti‐inflammatory bioactivities. However, the effect of DHM on atherosclerosis‐related pyroptosis has not been studied. In the present study, palmitic acid (PA) treatment led to pyroptosis in human umbilical vein endothelial cells (HUVECs), as evidenced by caspase‐1 activation, LDH release, and propidium iodide‐positive staining; enhanced th...
Source: BioFactors - September 10, 2017 Category: Biochemistry Authors: Qin Hu, Ting Zhang, Long Yi, Xi Zhou, Mantian Mi Tags: Research Communication Source Type: research

Kaempferol induces hepatocellular carcinoma cell death via endoplasmic reticulum stress-CHOP-autophagy signaling pathway.
Authors: Guo H, Lin W, Zhang X, Zhang X, Hu Z, Li L, Duan Z, Zhang J, Ren F Abstract Kaempferol is a flavonoid compound that has gained widespread attention due to its antitumor functions. However, the underlying mechanisms are still not clear. The present study investigated the effect of kaempferol on hepatocellular carcinoma and its underlying mechanisms. Kaempferol induced autophagy in a concentration- and time-dependent manner in HepG2 or Huh7 cells, which was evidenced by the significant increase of autophagy-related genes. Inhibition of autophagy pathway, through 3-methyladenine or Atg7 siRNA, strongly dimini...
Source: Oncotarget - July 28, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Investigation of morin-induced insulin secretion in cultured pancreatic cells.
This article is protected by copyright. All rights reserved. PMID: 28699234 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - July 12, 2017 Category: Drugs & Pharmacology Authors: Lin MH, Hsu CC, Lin J, Cheng JT, Wu MC Tags: Clin Exp Pharmacol Physiol Source Type: research

The Involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity.
Abstract Quercetin, one of the most abundant dietary flavonoids, is reported to have protective function against various hepatotoxicants-induced hepatotoxicity. The present study aims to investigate the critical role of nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidative signaling pathway in the protection of quercetin against hepatotoxicity. Quercetin prevented the cytotoxicity induced by a variety of hepatotoxicants including clivorine (Cliv), acetaminophen (APAP), ethanol, carbon tetrachloride (CCl4), and toosendanin (TSN) in human normal liver L-02 cells. Quercetin induced the nuclear translocatio...
Source: Free Radical Biology and Medicine - April 13, 2015 Category: Biology Authors: Ji LL, Sheng YC, Zheng ZY, Shi L, Wang ZT Tags: Free Radic Biol Med Source Type: research

Involvement of C/EBPβ in monocytic differentiation of acute myeloid leukemia cells induced by LW-218, a new synthesized flavonoid.
In this study, we found that LW-218, a new synthesized flavonoid, inhibited proliferation and induced differentiation of acute myeloid leukemia cells. The IC50s of LW-218 in HL-60, U937, K562, and NB4 cell lines were all less than 5 μM, suggesting greater capacity than compounds we have reported. LW-218 induced differentiation effects including morphologic changes, NBT reduction, and both of CD11b and CD14 expression. Results of western blots and siRNA transfection revealed that LW-218 increased the LAP/LIP ratio of C/EBPβ which regulated monocytic differentiation of leukemia cells. Meanwhile, these differentiation eff...
Source: Neoplasma - August 23, 2014 Category: Cancer & Oncology Authors: Wang Q, Hui H, Yang H, Li H, Gao Y, Li Z, Guo Q, Lu N Tags: Neoplasma Source Type: research

Concurrent Regulation of the Transcription Factors Nrf2 and ATF4 Mediates the Enhancement of Glutathione Levels by the Flavonoid Fisetin.
Abstract Glutathione (GSH) and GSH-associated metabolism provide the major line of defense for the protection of cells from various forms of toxic stress. GSH also plays a key role in regulating the intracellular redox environment. Thus, maintenance of GSH levels is developing into an important therapeutic objective for the treatment of a variety of diseases. Among the transcription factors that play critical roles in GSH metabolism are NF-E2-related factor 2 (Nrf2) and activating transcription factor 4 (ATF4). Thus, compounds that can upregulate these transcription factors may be particularly useful as treatment ...
Source: Biochemical Pharmacology - April 22, 2013 Category: Drugs & Pharmacology Authors: Ehren JL, Maher P Tags: Biochem Pharmacol Source Type: research