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Infectious Disease: Helicobacter Pylori

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Total 31 results found since Jan 2013.

Autophagy Is a Defense Mechanism Inhibiting Invasion and Inflammation During High-Virulent Haemophilus parasuis Infection in PK-15 Cells
In this study, we sought to investigate whether SH0165 (serovar 5, high-virulent strain) and HN0001 (serovar 6, non-virulent strain) infection induces autophagy and the specific role of autophagy in bacterial invasion and inflammation during H. parasuis infection. Moreover, we explored the mechanism underlying autophagy regulated inflammation through inflammatory signaling cascades during H. parasuis infection. This observation could provide useful information for further understanding the role of autophagy in H. parasuis infection and improve our knowledge of new strategies against this pathogen. Materials and Methods B...
Source: Frontiers in cellular and infection microbiology - April 15, 2019 Category: Microbiology Source Type: research

SFRP5 inhibits gastric epithelial cell migration induced by macrophage-derived Wnt5a
This study found that macrophages over-produced Wnt5a under the stimulation of Lipopolysaccharide (LPS) or Helicobacter pylori, the most common infectious agent in human stomach. Wnt5a-conditioned medium from macrophages enhanced cell migration and CXCR4 expression in either SFRP5-negative gastric epithelial cells (GEC) harboring SFRP5 methylation or SFRP5-positive cells treated with SFRP5 small interfering RNA (siRNA). However, such induced effect was remarkably eliminated by either Wnt5a siRNA in macrophages or treatment with recombinant SFRP5. We also found that Wnt5a-conditioned medium stimulated phosphorylation of c-j...
Source: Carcinogenesis - January 2, 2013 Category: Cancer & Oncology Authors: Zhao, C., Ma, H., Bu, X., Wang, W., Zhang, N. Tags: Original Manuscript Source Type: research

Helicobacter pylori Induces Increased Expression of the Vitamin D Receptor in Immune Responses
ConclusionsThe expression of VDR and CAMP in the gastric epithelium is up‐regulated in the case of H. pylori infection; thus, VDR plays an important role in gastric mucosa homeostasis and host protection from H. pylori infection.
Source: Helicobacter - November 5, 2013 Category: Gastroenterology Authors: Lihua Guo, Wenguo Chen, Huatuo Zhu, Yu Chen, Xingyong Wan, Ningmin Yang, Shuhua Xu, Chaohui Yu, Lihua Chen Tags: Original Article Source Type: research

Abstract 1143: Induction of epithelial-mesenchymal transition (EMT) in human gastric cancer cell lines induced by Tip{alpha} of H. pylori mediated through surface nucleolin
Conclusions: This is the first report that Tipα is a new inducer of EMT in human gastric cancer cells, and that EMT was induced through the binding of Tipα to surface nucleolin. Citation Format: Hirota Fujiki, Tatsuro Watanabe, Atsushi Takahashi, Kaori Suzuki, Miki Kurusu-Kanno, Kensei Yamaguchi, Masami Suganuma. Induction of epithelial-mesenchymal transition (EMT) in human gastric cancer cell lines induced by Tipα of H. pylori mediated through surface nucleolin. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Fujiki, H., Watanabe, T., Takahashi, A., Suzuki, K., Kurusu-Kanno, M., Yamaguchi, K., Suganuma, M. Tags: Tumor Biology Source Type: research

Effects of Helicobacter pylori and Heat Shock Protein 70 on the Proliferation of Human Gastric Epithelial Cells.
Conclusions. Coculture of H. pylori altered the proliferation of gastric epithelial cells and decreased HSP70 expression. HSP70 knockdown supplemented the inhibitory effect of H. pylori on proliferation of epithelial cells. These results indicate that the effects of H. pylori on the proliferation of gastric epithelial cells at least partially depend on the decreased expression of HSP70 induced by the bacterium. PMID: 25161665 [PubMed]
Source: Gastroenterology Research and Practice - November 26, 2014 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

MicroRNA ‐3178 ameliorates inflammation and gastric carcinogenesis promoted by Helicobacter pylori new toxin, Tip‐α, by targeting TRAF3
ConclusionsTaken all together, Tip‐α might activate NF‐κB to promote inflammation and carcinogenesis by inhibiting miR‐3178 expression, which directly targeting TRAF3, during H. pylori infection in gastric mucosal epithelial cells.
Source: Helicobacter - July 31, 2016 Category: Gastroenterology Authors: Meijuan Zou, Fang Wang, Aiqin Jiang, Anliang Xia, Siya Kong, Chun Gong, Mingxia Zhu, Xin Zhou, Jun Zhu, Wei Zhu, Wenfang Cheng Tags: Original Article Source Type: research

The leukocyte-associated immunoglobulin (Ig) –like receptor-1 modulating cell apoptosis and inflammatory cytokines secretion in THP-1 cells after Helicobacter pylori infection
Conclusion These results together indicated that LAIR-1 modulated cell apoptosis and inflammatory cytokines secretion in THP-1 cells, which might help sustain inflammation and prevent removal of the bacteria by the immune responses.
Source: Microbial Pathogenesis - June 19, 2017 Category: Infectious Diseases Source Type: research

Gastric Cancer Cell Lines Have Different MYC-Regulated Expression Patterns but Share a Common Core of Altered Genes.
Authors: Maués JHDS, Ribeiro HF, Pinto GR, Lopes LO, Lamarão LM, Pessoa CMF, Moreira-Nunes CFA, de Carvalho RM, Assumpção PP, Rey JA, Burbano RMR Abstract MYC is an oncogene responsible for excessive cell growth in cancer, enabling transcriptional activation of genes involved in cell cycle regulation, metabolism, and apoptosis, and is usually overexpressed in gastric cancer (GC). By using siRNA and Next-Generation Sequencing (NGS), we identified MYC-regulated differentially expressed Genes (DEGs) in three Brazilian gastric cancer cell lines representing the histological subtypes of GC (diffuse, intestinal, and ...
Source: Canadian Journal of Gastroenterology - November 11, 2018 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Helicobacter pylori activates NF‐κB by inducing Ubc13‐mediated ubiquitination of lysine 158 of TAK1
Abstract The Helicobacter pylori virulence factor CagA targets a variety of host proteins to alter different cellular responses, including the induction of pro‐inflammatory cytokines. We have previously shown that CagA‐facilitated lysine 63‐linked ubiquitination of TAK1 is essential for the H. pylori‐induced NF‐κB activation and the expression of proinflammatory cytokines. However, the molecular mechanism for TAK1 ubiquitination and activation in H. pylori‐mediated NF‐κB activation remains elusive. Here, we identify lysine 158 of TAK1 as the key residue undergoing lysine 63‐linked ubiquitination in respon...
Source: Journal of Cellular Biochemistry - April 19, 2013 Category: Biochemistry Authors: Acacia Lamb, JinJing Chen, Steven R. Blanke, Lin‐Feng Chen Tags: Article Source Type: research

Helicobacter pylori down‐regulates expression of human β‐defensin 1 in the gastric mucosa in a type IV secretion dependent fashion
Summary Helicobacter pylori establishes a chronic lifelong infection in the human gastric mucosa, which may lead to peptic ulcer disease or gastric adenocarcinoma. The human beta‐defensins (hβDs) are antimicrobial peptides, hβD1 being constitutively expressed in the human stomach. We hypothesised that H. pylori may persist, in part, by downregulating gastric hβD1 expression. We measured hβD1 and hβD2 expression in vivo in relation to the presence, density and severity of H. pylori infection, investigated differential effects of H. pylori virulence factors, and studied underlying signalling mechanisms in vitro. Signi...
Source: Cellular Microbiology - July 29, 2013 Category: Microbiology Authors: S.R. Patel, K. Smith, D.P. Letley, K.W. Cook, A.A. Memon, R.J.M. Ingram, E. Staples, S. Backert, A.M. Zaitoun, J.C. Atherton, K. Robinson Tags: Research Article Source Type: research

Helicobacter pylori-induced post-transcriptional regulation of H,K-ATPase α subunit gene expression by miRNA.
Abstract Acute H. pylori infection of gastric epithelial cells induces CagA oncoprotein- and peptidoglycan (SLT)-dependent mobilization of NF-κB p50 homodimers that bind to H,K-ATPase α subunit (HKα) promoter and repress HKα gene transcription. This process may facilitate gastric H. pylori colonization by induction of transient hypochlorhydria. We hypothesized that H. pylori also regulates HKα expression post-transcriptionally by miRNA interaction with HKα mRNA. In silico analysis of HKα 3' untranslated region (UTR) identified miR-1289 as a highly-conserved putative HKα-regulatory miRNA. H. pylori infectio...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - February 6, 2014 Category: Physiology Authors: Zhang YM, Noto JM, Hammond CE, Barth JL, Argraves WS, Backert S, Peek RM, Smolka AJ Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Helicobacter pylori-induced posttranscriptional regulation of H-K-ATPase {alpha}-subunit gene expression by miRNA
Acute Helicobacter pylori infection of gastric epithelial cells induces CagA oncoprotein- and peptidoglycan (SLT)-dependent mobilization of NF-B p50 homodimers that bind to H-K-ATPase α-subunit (HKα) promoter and repress HKα gene transcription. This process may facilitate gastric H. pylori colonization by induction of transient hypochlorhydria. We hypothesized that H. pylori also regulates HKα expression posttranscriptionally by miRNA interaction with HKα mRNA. In silico analysis of the HKα 3' untranslated region (UTR) identified miR-1289 as a highly conserved putative HKα-regulato...
Source: AJP: Gastrointestinal and Liver Physiology - April 1, 2014 Category: Gastroenterology Authors: Zhang, Y.-M., Noto, J. M., Hammond, C. E., Barth, J. L., Argraves, W. S., Backert, S., Peek, R. M., Smolka, A. J. Tags: MUCOSAL BIOLOGY Source Type: research

The focal complex of epithelial cells provides a signaling platform for interleukin‐8 induction in response to bacterial pathogens
We examined the interaction of several bacterial pathogens with host cells, including Campylobacter jejuni, to determine if the FC is required for induction of chemokine signaling in response to bacterial pathogens. Our data indicate that secretion of IL‐8 is triggered by C. jejuni, Helicobacter pylori, and Salmonella enterica serovar Typhimurium in response to engagement of β1 integrins. Additionally, we found that the secretion of IL‐8 from C. jejuni infected epithelial cells requires FAK, Src, and paxillin, which in turn are necessary for Erk 1/2 recruitment and activation. Targeting the FC component paxillin with ...
Source: Cellular Microbiology - April 29, 2014 Category: Microbiology Authors: Tyson P. Eucker, Derrick R. Samuelson, Mary Hunzicker‐Dunn, Michael E. Konkel Tags: Research Article Source Type: research

The focal complex of epithelial cells provides a signalling platform for interleukin‐8 induction in response to bacterial pathogens
We examined the interaction of several bacterial pathogens with host cells, including Campylobacter jejuni, to determine if the FC is required for induction of chemokine signalling in response to bacterial pathogens. Our data indicate that secretion of IL‐8 is triggered by C. jejuni, Helicobacter pylori and Salmonella enterica serovar Typhimurium in response to engagement of β1 integrins. Additionally, we found that the secretion of IL‐8 from C. jejuni infected epithelial cells requires FAK, Src and paxillin, which in turn are necessary for Erk 1/2 recruitment and activation. Targeting the FC component paxillin with s...
Source: Cellular Microbiology - June 2, 2014 Category: Microbiology Authors: Tyson P. Eucker, Derrick R. Samuelson, Mary Hunzicker‐Dunn, Michael E. Konkel Tags: Research Article Source Type: research

Abstract 883: Angiopoietin-like protein 2, a driver of cancer cell metastasis, is a novel serum biomarker for the diagnosis and prognosis in patients with gastric cancer
Background: Gastric carcinogenesis is regarded as a multistep process with an intestinal metaplasia-dysplasia-carcinoma sequence, which is initiated by Helicobacter pylori infection that causes a chronic active inflammation in the gastric mucosa. Angiopoietin-like protein 2 (ANGPTL2) is known to act as a causative mediator of chronic inflammation and inflammatory carcinogenesis. However, the biological role and clinical significance of ANGPTL2 expression remains poorly understood in human cancer. We investigated the functional role of ANGPTL2 and evaluated the clinical significance of its expression in both primary tumor a...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Toiyama, Y., Kitajima, T., Shimura, T., Imaoka, H., Kondo, S., Ide, S., Okigami, M., Yasuda, H., Saigusa, S., Ohi, M., Tanaka, K., Inoue, Y., Mhori, Y., Goel, A., Kusunoki, M. Tags: Clinical Research (Excluding Clinical Trials) Source Type: research