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Source: Theranostics
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Total 110 results found since Jan 2013.
Silencing PCBP2 normalizes desmoplastic stroma and improves the antitumor activity of chemotherapy in pancreatic cancer
Conclusion: This approach provides a new therapeutic avenue to improve the antitumor efficacy of PDAC therapies by normalizing tumor stroma using the PCBP2 siRNA nanocomplex.
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Yuanke Li, Zhen Zhao, Chien-Yu Lin, Yanli Liu, Kevin F. Staveley-OCarroll, Guangfu Li, Kun Cheng Tags: Research Paper Source Type: research
Platelet-derived microvesicles induce calcium oscillations and promote VSMC migration via TRPV4
Conclusions: TRPV4 participated in the calcium oscillations and VSMC migration induced by PMVs. PMVs and the related molecules might be novel therapeutic targets for vascular remodeling during vascular injury.
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Shan-Shan Li, Shuang Gao, Yi Chen, Han Bao, Zi-Tong Li, Qing-Ping Yao, Ji-Ting Liu, Yingxiao Wang, Ying-Xin Qi Tags: Research Paper Source Type: research
CCL16 maintains stem cell-like properties in breast cancer by activating CCR2/GSK3 β / β -catenin/OCT4 axis
Conclusions: We identified a potential CSC regulator and suggest a novel mechanism for how CCL16 governs cancer cell stemness. We propose that CCL16 could be an effective target for breast cancer therapy.
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Wenzhi Shen, Xiaoyuan Zhang, Jiaping Tang, Zhixin Zhang, Renle Du, Dehong Luo, Xiaoran Liu, Yong Xia, Yanping Li, Shanshan Wang, Siyuan Yan, Wancai Yang, Rong Xiang, Na Luo, Yunping Luo, Jianjun Li Tags: Research Paper Source Type: research
Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish
Conclusions: These findings pointed out that the compound heterozygous mutations in human LPIN1 caused adult-onset syndromic myasthenia with peripheral neuropathy. Moreover, zebrafish could be used to model the neuromuscular phenotypes due to the lipin 1 deficiency, where a novel pathological role of over-activated Notch signaling was discovered and further confirmed in mammalian cell lines.
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Shuxian Lu, Zhaojie Lyu, Zhihao Wang, Yao Kou, Cong Liu, Shengyue Li, Mengyan Hu, Hongjie Zhu, Wenxing Wang, Ce Zhang, Yung-Shu Kuan, Yi-Wen Liu, Jianming Chen, Jing Tian Tags: Research Paper Source Type: research
Histone demethylase JMJD3 protects against renal fibrosis by suppressing TGF β and Notch signaling and preserving PTEN expression
Conclusion: These results indicate that JMJD3 confers anti-fibrotic effects by limiting activation of multiple profibrotic signaling pathways and suggest that JMJD3 modulation may have therapeutic effects for chronic kidney disease.
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Chao Yu, Chongxiang Xiong, Jinhua Tang, Xiying Hou, Na Liu, George Bayliss, Shougang Zhuang Tags: Research Paper Source Type: research
Co-delivery of siPTPN13 and siNOX4 via (myo)fibroblast-targeting polymeric micelles for idiopathic pulmonary fibrosis therapy
Conclusion: The (myo)fibroblast-targeting dual siRNA-loaded micelles offer a potential strategy with promising prospects in molecular-targeted fibrosis therapy.
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Jiwei Hou, Qijian Ji, Jie Ji, Shenghong Ju, Chun Xu, Xueqing Yong, Xiaoxuan Xu, Mohd. Muddassir, Xiang Chen, Jinbing Xie, Xiaodong Han Tags: Research Paper Source Type: research
USP7 targeting modulates anti-tumor immune response by reprogramming Tumor-associated Macrophages in Lung Cancer
Conclusions: Taken together, these results provide evidence to suggest that therapeutic approaches targeting USP7, in combination with immunotherapy, should be considered for lung cancer treatment.
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Xiaomeng Dai, Lisen Lu, Suke Deng, Jingshu Meng, Chao Wan, Jing Huang, Yajie Sun, Yan Hu, Bian Wu, Gang Wu, Jonathan F. Lovell, Honglin Jin, Kunyu Yang Tags: Research Paper Source Type: research
Cardiomyocyte-derived small extracellular vesicles can signal eNOS activation in cardiac microvascular endothelial cells to protect against Ischemia/Reperfusion injury
Conclusions: These data uncover a mechanism by which the crosstalk between CMs and CMECs leads to the increased survival of the heart after I/R injury and point to a new therapeutic target for the blunting of myocardial I/R injury.
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Guihao Chen, Chuansheng Xu, Thomas G. Gillette, Tongyi Huang, Peisen Huang, Qing Li, Xiangdong Li, Qinfeng Li, Yu Ning, Ruijie Tang, Cunrong Huang, Yuyan Xiong, Xiaqiu Tian, Jun Xu, Junyan Xu, Liping Chang, Cong Wei, Chen Jin, Joseph A. Hill, Yuejin Yang Tags: Research Paper Source Type: research
Nanoscale microenvironment engineering based on layer-by-layer self-assembly to regulate hair follicle stem cell fate for regenerative medicine
Conclusion: This study provides novel methods for the construction of stem cell microenvironments and experimental models of HF regeneration for the treatment of hair loss.
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Peng Chen, Yong Miao, Feifei Zhang, Junfei Huang, Yuxin Chen, Zhexiang Fan, Lunan Yang, Jin Wang, Zhiqi Hu Tags: Research Paper Source Type: research
CXCR4 induces cell autophagy and maintains EBV latent infection in EBVaGC
Conclusions: Our data suggested new roles for CXCR4 in autophagy and EBV replication in EBVaGC, which further promoted cell survival and persistent latent infection. These new findings can lead to further CXCR4-based anticancer therapy.
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Weiwen Wang, Yan Zhang, Wen Liu, Xiangyan Zhang, Hua Xiao, Menghe Zhao, Bing Luo Tags: Research Paper Source Type: research
Increased intracellular Cl- concentration improves airway epithelial migration by activating the RhoA/ROCK Pathway
Conclusion: Taken together, these results suggested that Cl- accumulation in airway epithelial cells could activate the RhoA/ROCK/LIMK cascade to induce F-actin reorganization, down-regulate cell stiffness, and improve epithelial migration.
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Wenjie Huang, Meiling Tan, Yue Wang, Lei Liu, Yan Pan, Jingjing Li, Mingxing Ouyang, Chunjiao Long, Xiangping Qu, Huijun Liu, Chi Liu, Jia Wang, Linhong Deng, Yang Xiang, Xiaoqun Qin Tags: Research Paper Source Type: research
pH-responsive DNA nanomicelles for chemo-gene synergetic therapy of anaplastic large cell lymphoma
Conclusion: DNMs co-loaded with Dox and ALK-specific siRNA exhibited significantly enhanced apoptosis of ALCL K299 cells in vitro and effectively inhibited tumor growth in vivo without obvious toxicity, providing a potential strategy in the development of nanomedicines for synergetic cancer therapy.
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Yuwei Li, Shuzhen Yue, Jingyu Cao, Chengzhan Zhu, Yixiu Wang, Xin Hai, Weiling Song, Sai Bi Tags: Research Paper Source Type: research
Flubendazole elicits anti-cancer effects via targeting EVA1A-modulated autophagy and apoptosis in Triple-negative Breast Cancer
Conclusion: Our results provide novel insights towards the putative anti-cancer efficacy of flubendazole. Furthermore, here we show that flubendazole could serve as a potential therapeutic drug in TNBC. Altogether, this study highlights the possibility of this repurposed autophagic inducer for future cancer treatments.
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Yongqi Zhen, Rongyan Zhao, Minjuan Wang, Xing Jiang, Feng Gao, Leilei Fu, Lan Zhang, Xian-Li Zhou Tags: Research Paper Source Type: research
circ-PRKCB acts as a ceRNA to regulate p66Shc-mediated oxidative stress in intestinal ischemia/reperfusion
Conclusions: Our findings reveal a crucial role for the circ-PRKCB/miR-339-5p/p66Shc signaling pathway in regulating oxidative stress in the I/R intestine. This pathway may be a potential therapeutic target for intestinal I/R injury.
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Dongcheng Feng, Zhecheng Wang, Yan Zhao, Yang Li, Deshun Liu, Zhao Chen, Shili Ning, Yan Hu, Jihong Yao, Xiaofeng Tian Tags: Research Paper Source Type: research
Low-intensity Pulsed Ultrasound regulates alveolar bone homeostasis in experimental Periodontitis by diminishing Oxidative Stress
Conclusions: These results demonstrated that LIPUS regulates alveolar bone homeostasis in periodontitis by attenuating oxidative stress via the regulation of PI3K-Akt/Nrf2 signaling. Thus, Nrf2 plays a pivotal role in the protective effect exerted by LIPUS against ligature-induced experimental periodontitis.
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Siqi Ying, Minmin Tan, Ge Feng, Yunchun Kuang, Duanjing Chen, Jie Li, Jinlin Song Tags: Research Paper Source Type: research
