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Source: Theranostics
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Total 110 results found since Jan 2013.
Optimizing use of theranostic nanoparticles as a life-saving strategy for treating COVID-19 patients
On the 30th of January 2020, the World Health Organization fired up the sirens against a fast spreading infectious disease caused by a newly discovered Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and gave this disease the name COVID-19. While there is currently no specific treatment for COVID-19, several off label drugs approved for other indications are being investigated in clinical trials across the globe.In the last decade, theranostic nanoparticles were reported as promising tool for efficiently and selectively deliver therapeutic moieties (i.e. drugs, vaccines, siRNA, peptide) to target sites of infe...
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Rasha Itani, Mansour Tobaiqy, Achraf Al Faraj Tags: Review Source Type: research
Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome/circHIPK3/ FOXO3a pathway
Conclusions: Using loss/gain-of function method, we demonstrated that miR-421/FOXO3a is the direct target of circHIPK3, and UMSC-Exo prevent ischemic injury by releasing circHIPK3, which in turn down regulate miR-421, resulting in increased expression of FOXO3a, leading to inhibition of pyroptosis and release of IL-1β and IL-18.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Bing Yan, Yu Zhang, Chun Liang, Bin Liu, Fengzhi Ding, Yanli Wang, Bao Zhu, Ranzun Zhao, Xi-Yong Yu, Yangxin Li Tags: Research Paper Source Type: research
Multifunctional N-P-doped carbon dots for regulation of apoptosis and autophagy in B16F10 melanoma cancer cells and in vitro imaging applications
Conclusion: Based on these findings, we conclude that our newly synthesized NPCDs induced cell cycle arrest, autophagy, and apoptosis in B16F10 melanoma cells and presented good cellular bioimaging capability.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Vivek K. Bajpai, Imran Khan, Shruti Shukla, Sung-Min Kang, Faisal Aziz, Kumud Malika Tripathi, Deepika Saini, Hye-Jin Cho, Nam Su Heo, Sumit K. Sonkar, Lei Chen, Yun Suk Huh, Young-Kyu Han Tags: Research Paper Source Type: research
ClC-7 Regulates the Pattern and Early Development of Craniofacial Bone and Tooth
Conclusion: These findings highlighted the vital role of clcn7 in zebrafish craniofacial bone and tooth development and mineralization, revealing novel insights for the causation of osteopetrosis with CLCN7 mutations. The mechanism chain of ClC-7/CTSK/ TGF-β/BMP/SMAD might explain the typical craniofacial bone and tooth changes in osteopetrosis as well as pycnodysostosis patients.
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Yanli Zhang, Dongrui Ji, Lin Li, Shaoqing Yang, Hengwei Zhang, Xiaohong Duan Tags: Research Paper Source Type: research
Therapeutic effects of human monoclonal PSMA antibody-mediated TRIM24 siRNA delivery in PSMA-positive castration-resistant prostate cancer
Conclusion: PSMAb mediated TRIM24 siRNA delivery platform could significantly inhibit cell proliferation, colony-formation, and invasion in PSMA+ CRPC in vitro and suppressed tumor growth and bone loss in PSMA+ CRPC xenograft and bone metastasis model.
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Sheng-Jia Shi, Li-Juan Wang, Dong-Hui Han, Jie-Heng Wu, Dian Jiao, Kai-Liang Zhang, Jiang-Wei Chen, Yu Li, Fa Yang, Jing-Liang Zhang, Guo-Xu Zheng, An-Gang Yang, Ai-Zhi Zhao, Wei-Jun Qin, Wei-Hong Wen Tags: Research Paper Source Type: research
Anti-EGF Receptor Aptamer-Guided Co-Delivery of Anti-Cancer siRNAs and Quantum Dots for Theranostics of Triple-Negative Breast Cancer
Conclusion: In general, the aptamo-QLs showed competitive in vivo delivery and therapeutic efficacy compared to immuno-QLs under the same experimental conditions. Our results show that the anti-EGFR aptamer-guided lipid carriers may be a potential theranostic delivery vehicle for RNA interference and fluorescence imaging of TNBCs.
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Min Woo Kim, Hwa Yeon Jeong, Seong Jae Kang, In Ho Jeong, Moon Jung Choi, Young Myoung You, Chan Su Im, In Ho Song, Tae Sup Lee, Jin Suk Lee, Aeju Lee, Yong Serk Park Tags: Research Paper Source Type: research
VEGFC acts as a double-edged sword in renal cell carcinoma aggressiveness
Conclusion: Our study revisited the admitted dogma linking VEGFC to tumor aggressiveness. We conclude that targeting VEGFC for therapy must be considered with caution.
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Papa Diogop Ndiaye, Maeva Dufies, Sandy Giuliano, Laetitia Douguet, Renaud Gr é pin, J é r ô me Durivault, Philippe Lenormand, Natacha Glisse, Janita Mintcheva, Val é rie Vouret-Craviari, Baharia Mograbi, Maud Wurmser, Damien Ambrosetti, Nathalie Riou Tags: Research Paper Source Type: research
Development of a Biocompatible Copolymer Nanocomplex to Deliver VEGF siRNA for Triple Negative Breast Cancer
Conclusion: PLEGP1800 is a safe and efficient copolymer to deliver siRNAs for TNBC therapy. It could potentially be applied to other cancers by changing the cargo and incorporating tumor-specific ligands.
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Zhen Zhao, Yuanke Li, Ravi Shukla, Hao Liu, Akshay Jain, Ashutosh Barve, Kun Cheng Tags: Research Paper Source Type: research
Nuclear Entry of CRTC1 as Druggable Target of Acquired Pigmentary Disorder
Conclusion: We propose the targeting of CRTC1 as a unique strategy in the treatment of acquired pigmentary disorders.
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Cheong-Yong Yun, Seung Deok Hong, Young Hee Lee, Jiyeon Lee, Da-Eun Jung, Ga Hyun Kim, Song-Hee Kim, Jae-Kyung Jung, Ki Ho Kim, Heesoon Lee, Jin Tae Hong, Sang-Bae Han, Youngsoo Kim Tags: Research Paper Source Type: research
ZnAs@SiO2 nanoparticles as a potential anti-tumor drug for targeting stemness and epithelial-mesenchymal transition in hepatocellular carcinoma via SHP-1/JAK2/STAT3 signaling
Conclusions: ZnAs@SiO2 NPs can effectively suppress tumor initiation, growth, metastasis, and inhibit stemness and EMT through regulation of SHP-1/JAK2/STAT3 signaling pathway in liver cancer cells in vitro and in vivo. Thus, ZnAs@SiO2 NPs have immense potential for HCC treatment in the future.
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Yongquan Huang, Bin Zhou, Hui Luo, Junjie Mao, Yin Huang, Ke Zhang, Chaoming Mei, Yan Yan, Hongjun Jin, Jinhao Gao, Zhongzhen Su, Pengfei Pang, Dan Li, Hong Shan Tags: Research Paper Source Type: research
Autophagy impairment contributes to PBDE-47-induced developmental neurotoxicity and its relationship with apoptosis
Conclusion: Our data suggest that autophagy impairment facilitates apoptosis, which, in turn, disrupts autophagy, ultimately resulting in cell death, and that autophagy may act as a promising therapeutic target for PBDE-47-induced developmental neurotoxicity.
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Pei Li, Rulin Ma, Lixin Dong, Luming Liu, Guoyu Zhou, Zhiyuan Tian, Qian Zhao, Tao Xia, Shun Zhang, Aiguo Wang Tags: Research Paper Source Type: research
COL4A2 in the tissue-specific extracellular matrix plays important role on osteogenic differentiation of periodontal ligament stem cells
Conclusion: These findings indicate that COL4A2 in the ECM promotes osteogenic differentiation of PDLSCs through negative regulation of the Wnt/β-catenin pathway, which can be used as a potential therapeutic strategy to repair bone defects.
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Yi Wen, Hongxu Yang, Junjie Wu, Axian Wang, Xiaodong Chen, Sijun Hu, Yuxing Zhang, Ding Bai, Zuolin Jin Tags: Research Paper Source Type: research
Delayed Remote Ischemic Preconditioning ConfersRenoprotection against Septic Acute Kidney Injury via Exosomal miR-21
Conclusion: This study demonstrates a critical role for exosomal miR-21 in renoprotection conferred by limb rIPC against sepsis and suggests that rIPC and exosomes might serve as the possible therapeutic strategies for sepsis-induced kidney injury.
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Tianyi Pan, Ping Jia, Nan Chen, Yi Fang, Yiran Liang, Man Guo, Xiaoqiang Ding Tags: Research Paper Source Type: research
Supramolecular Assemblies of Peptides or Nucleopeptides for Gene Delivery
Using non-covalent interactions between nucleic acids (DNA, siRNA, miRNA, and mRNA) with peptides or nucleopeptides is a promising strategy to construct supramolecular assemblies for gene delivery and therapy. Comparing to conventional strategies for gene delivery, the assemblies of peptides or nucleopeptides provide several unique advantages: i) reversible interactions between the assemblies and the nucleic acids; ii) minimal immunogenicity; iii) biocompatibility. This field has advanced considerably in recent years so that it is worth summarizing the recent progresses and future challenges. In this review, we introduce t...
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Huaimin Wang, Zhaoqianqi Feng, Bing Xu Tags: Review Source Type: research
EGFR drives the progression of AKI to CKD through HIPK2 overexpression
Conclusion: These data suggest that EGFR plays an important role in VAN-driven progression of AKI to CKD.
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Luyang Xu, Xiaozhou Li, Fei Zhang, Lidong Wu, Zheng Dong, Dongshan Zhang Tags: Research Paper Source Type: research
