Autophagy impairment contributes to PBDE-47-induced developmental neurotoxicity and its relationship with apoptosis

Conclusion: Our data suggest that autophagy impairment facilitates apoptosis, which, in turn, disrupts autophagy, ultimately resulting in cell death, and that autophagy may act as a promising therapeutic target for PBDE-47-induced developmental neurotoxicity.

Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Pei Li, Rulin Ma, Lixin Dong, Luming Liu, Guoyu Zhou, Zhiyuan Tian, Qian Zhao, Tao Xia, Shun Zhang, Aiguo Wang Tags: Research Paper Source Type: research