Filtered By:
Source: Theranostics
This page shows you your search results in order of date. This is page number 3.
Order by Relevance | Date
Total 110 results found since Jan 2013.
Cadherin-11 cooperates with inflammatory factors to promote the migration and invasion of fibroblast-like synoviocytes in pigmented villonodular synovitis
Conclusions: Cadherin-11 plays an important role in the pathogenesis of PVNS and forms a positive feedback loop with inflammatory factors, which further activates the NF-κB and MAPK pathways to trigger an inflammatory cascade. Cadherin-11-mediated inflammation results in PVNS with high recurrence, invasiveness, and strong cartilage destruction ability, and eventually promotes the transformation of PVNS from the initial inflammatory disease to neoplastic disease. Thus, inhibition of cadherin-11 together with its related inflammatory reaction, represents a new therapeutic strategy for PVNS.
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Chenxi Cao, Fei Wu, Xingyue Niu, Xiaoqing Hu, Jin Cheng, Yan Zhang, Chuanyun Li, Xiaoning Duan, Xin Fu, Jiying Zhang, Xin Zhang, Yingfang Ao Tags: Research Paper Source Type: research
Stem Cell Factor-Inducible MITF-M Expression in Therapeutics for Acquired Skin Hyperpigmentation
Conclusion: We propose the targeting of SCF/KIT-inducible MITF-M expression as a strategy in the therapeutics for acquired pigmentary disorders.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Cheong-Yong Yun, Eunmiri Roh, Song-Hee Kim, Jinhe Han, Jiyeon Lee, Da-Eun Jung, Ga Hyeon Kim, Sang-Hun Jung, Won-Jea Cho, Sang-Bae Han, Youngsoo Kim Tags: Research Paper Source Type: research
Fusobacterium nucleatum Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression
Conclusions: F. nucleatum is enriched in CRC tissues from patients with metastasis. F. nucleatum orchestrates CARD3 and autophagy to control CRC metastasis. Measuring and targeting F. nucleatum and its associated pathways will yield approaches for the prevention and treatment of CRC metastasis.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Yongyu Chen, Yan Chen, Jixiang Zhang, Pan Cao, Wenhao Su, Yunchao Deng, Na Zhan, Xiangsheng Fu, Yun Huang, Weiguo Dong Tags: Research Paper Source Type: research
RNA Nanotechnology-Mediated Cancer Immunotherapy
RNA molecules (e.g., siRNA, microRNA, and mRNA) have shown tremendous potential for immunomodulation and cancer immunotherapy. They can activate both innate and adaptive immune system responses by silencing or upregulating immune-relevant genes. In addition, mRNA-based vaccines have recently been actively pursued and tested in cancer patients, as a form of treatment. Meanwhile, various nanomaterials have been developed to enhance RNA delivery to the tumor and immune cells. In this review article, we summarize recent advances in the development of RNA-based therapeutics and their applications in cancer immunotherapy. We als...
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Yao-Xin Lin, Yi Wang, Sara Blake, Mian Yu, Lin Mei, Hao Wang, Jinjun Shi Tags: Review Source Type: research
Mononuclear phagocyte system blockade improves therapeutic exosome delivery to the myocardium
Conclusions: Prior blocking of endocytosis of exosomes by macrophages with exosomeblocking successfully and efficiently improves the distribution of following exosometherapeutic in targeted organs, like the heart. The established two-step exosome delivery strategy (blocking the uptake of exosomes first followed by delivery of therapeutic exosomes) would be a promising method for gene therapy.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Zhuo Wan, Lianbi Zhao, Fan Lu, Xiaotong Gao, Yan Dong, Yingxin Zhao, Mengying Wei, Guodong Yang, Changyang Xing, Li Liu Tags: Research Paper Source Type: research
Silica Perturbs Primary Cilia and Causes Myofibroblast Differentiation during Silicosis by Reduction of the KIF3A-Repressor GLI3 Complex
Conclusion: Our findings indicate that primary cilia are markedly altered during silicosis and the loss of KIF3A may promote myofibroblast differentiation induced by SiO2.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Shifeng Li, Zhongqiu Wei, Gengxu Li, Qiaodan Zhang, Siyu Niu, Dingjie Xu, Na Mao, Si Chen, Xuemin Gao, Wenchen Cai, Ying Zhu, Guizhen Zhang, Dan Li, Xue Yi, Fang Yang, Hong Xu Tags: Research Paper Source Type: research
SREBP1 siRNA enhance the docetaxel effect based on a bone-cancer dual-targeting biomimetic nanosystem against bone metastatic castration-resistant prostate cancer
Conclusion: This study presented a bone-cancer dual-targeting biomimetic nanodelivery system for bone metastatic CRPC.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Jiyuan Chen, Zhenjie Wu, Weihong Ding, Chengwu Xiao, Yu Zhang, Shen Gao, Yuan Gao, Weimin Cai Tags: Research Paper Source Type: research
RNA-based scaffolds for bone regeneration: application and mechanisms of mRNA, miRNA and siRNA
Globally, more than 1.5 million patients undergo bone graft surgeries annually, and the development of biomaterial scaffolds that mimic natural bone for bone grafting remains a tremendous challenge. In recent decades, due to the improved understanding of the mechanisms of bone remodeling and the rapid development of gene therapy, RNA (including messenger RNA (mRNA), microRNA (miRNA), and short interfering RNA (siRNA)) has attracted increased attention as a new tool for bone tissue engineering due to its unique nature and great potential to cure bone defects. Different types of RNA play roles via a variety of mechanisms in ...
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Qiuping Leng, Lini Chen, Yonggang Lv Tags: Review Source Type: research
FGF9 induces functional differentiation to Schwann cells from human adipose derived stem cells
Conclusions: Our data therefore demonstrate the importance of FGF9 in the determination of SC fate via the FGF9-FGFR2-Akt pathway and reveal the therapeutic benefit of FGF9-NLCs.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Chia-Wei Huang, Shih-Yu Lu, Tzu-Chieh Huang, Bu-Miim Huang, H. Sunny Sun, Shang-Hsun Yang, Jih-Ing Chuang, Yuan-Yu Hsueh, Yi-Ting Wu, Chia-Ching Wu Tags: Research Paper Source Type: research
Dysbiosis of intestinal microbiota mediates tubulointerstitial injury in diabetic nephropathy via the disruption of cholesterol homeostasis
Conclusion: Our studies for the first time demonstrated that the acetate produced from gut microbiota mediated the dysregulation of cholesterol homeostasis through the activation of GPR43, thereby contributing to the tubulointerstitial injury of DN, suggesting that gut microbiota reprogramming might be a new strategy for DN prevention and therapy.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Ze Bo Hu, Jian Lu, Pei Pei Chen, Chen Chen Lu, Jia Xiu Zhang, Xue Qi Li, Ben Yin Yuan, Si Jia Huang, Xiong Zhong Ruan, Bi Cheng Liu, Kun Ling Ma Tags: Research Paper Source Type: research
A novel function of Prohibitin on melanosome transport in melanocytes
Conclusion: PHB regulates melanosome transport by linking to Rab27a and Mlph in melanocytes. Targeting and regulating PHB not only manages pigmentation in melanocytes, but also controls hyperpigmentation in melanoma
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Chan Song Jo, Hye In Park, Hyun Jin Jung, Jong il Park, Ji Eun Lee, Cheol Hwan Myung, Jae Sung Hwang Tags: Research Paper Source Type: research
Bioinspired tumor-homing nanoplatform for co-delivery of paclitaxel and siRNA-E7 to HPV-related cervical malignancies for synergistic therapy
Conclusion: Si/PNPs@HeLa, by integrating immune escape and tumor-homing ability, can serve as an efficient dual-drug delivery system to achieve precise treatment of cervical cancer through chemo-gene combined therapy.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Cong Xu, Wan Liu, Yuan Hu, Weiping Li, Wen Di Tags: Research Paper Source Type: research
Identification of a novel microRNA-141-3p/Forkhead box C1/ β -catenin axis associated with rheumatoid arthritis synovial fibroblast function in vivo and in vitro
Conclusions: FoxC1 and miR-141-3p participate in RA pathogenesis by mediating inflammation and SF proliferation, migration, and invasion and thus could be novel targets for RA therapy as a nonimmunosuppressive approach.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Jun Wang, Yin Wang, Hui Zhang, Jun Chang, Ming Lu, Weilu Gao, Wendong Liu, Yetian Li, Li Yin, Xiaohe Wang, Yuejun Wang, Mengru Gao, Zongsheng Yin Tags: Research Paper Source Type: research
Targeted sequencing reveals the mutational landscape responsible for sorafenib therapy in advanced hepatocellular carcinoma
Conclusion: Our study reported a novel somatic mutation in OCT4 (c.G52C) responsible for the sorafenib effect, and also shed new light on the treatment of HCC through the combination of specific tyrosine kinase inhibitors according to individual genetic patterns.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Jing Tang, Cheng-Jun Sui, Dong-Fang Wang, Xin-Yuan Lu, Gui-Juan Luo, Qing Zhao, Qiu-Yu Lian, Seogsong Jeong, Xi-Meng Lin, Yan-Jing Zhu, Bo Zheng, Rui Wu, Qing Wang, Xiao-Long Liu, Jing-Feng Liu, Qiang Xia, Gang Wu, Jin Gu, Hong-Yang Wang, Lei Chen Tags: Research Paper Source Type: research
Tumor-neuroglia interaction promotes pancreatic cancer metastasis
Conclusion: Schwann cells were extensively distributed in the PDAC tumor microenvironment and high level of intra-tumoral SC markers could serve as an independent prognostic factor for poor survival of patients with PDAC. The tumor-neuroglia interaction is indispensable for SCs to acquire a tumor-facilitating phenotype. Targeting the tumor-neuroglia interplay might be a promising strategy to treat PDAC.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Dan Su, Xiaofeng Guo, Leyi Huang, Huilin Ye, Zhiguo Li, Longfa Lin, Rufu Chen, Quanbo Zhou Tags: Research Paper Source Type: research
