Histone demethylase JMJD3 protects against renal fibrosis by suppressing TGF β and Notch signaling and preserving PTEN expression

Conclusion: These results indicate that JMJD3 confers anti-fibrotic effects by limiting activation of multiple profibrotic signaling pathways and suggest that JMJD3 modulation may have therapeutic effects for chronic kidney disease.

Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Chao Yu, Chongxiang Xiong, Jinhua Tang, Xiying Hou, Na Liu, George Bayliss, Shougang Zhuang Tags: Research Paper Source Type: research