Increased intracellular Cl- concentration improves airway epithelial migration by activating the RhoA/ROCK Pathway

Conclusion: Taken together, these results suggested that Cl- accumulation in airway epithelial cells could activate the RhoA/ROCK/LIMK cascade to induce F-actin reorganization, down-regulate cell stiffness, and improve epithelial migration.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Wenjie Huang, Meiling Tan, Yue Wang, Lei Liu, Yan Pan, Jingjing Li, Mingxing Ouyang, Chunjiao Long, Xiangping Qu, Huijun Liu, Chi Liu, Jia Wang, Linhong Deng, Yang Xiang, Xiaoqun Qin Tags: Research Paper Source Type: research