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Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research
Cancers, Vol. 14, Pages 5367: The Histone Methyltransferase SETD8 Regulates the Expression of Tumor Suppressor Genes via H4K20 Methylation and the p53 Signaling Pathway in Endometrial Cancer Cells
We examined the expression profile of SETD8 and evaluated whether SETD8 plays a critical role in the proliferation of endometrial cancer cells using small interfering RNAs (siRNAs). We identified the prognostically important genes regulated by SETD8 via H4K20 methylation and p53 signaling using chromatin immunoprecipitation sequencing, RNA sequencing, and machine learning. We confirmed that SETD8 expression was elevated in endometrial cancer tissues. Our in vitro results suggest that the suppression of SETD8 using siRNA or a selective inhibitor attenuated cell proliferation and promoted the apoptosis of endometrial cancer ...
Source: Cancers - October 31, 2022 Category: Cancer & Oncology Authors: Asako Kukita Kenbun Sone Syuzo Kaneko Eiryo Kawakami Shinya Oki Machiko Kojima Miku Wada Yusuke Toyohara Yu Takahashi Futaba Inoue Saki Tanimoto Ayumi Taguchi Tomohiko Fukuda Yuichiro Miyamoto Michihiro Tanikawa Mayuyo Mori-Uchino Tetsushi Tsuruga Takayuk Tags: Article Source Type: research
Preclinical-to-clinical Anti-cancer Drug Response Prediction and Biomarker Identification Using TINDL
Genomics Proteomics Bioinformatics. 2023 Feb 10:S1672-0229(23)00032-3. doi: 10.1016/j.gpb.2023.01.006. Online ahead of print.ABSTRACTPrediction of the response of cancer patients to different treatments and identification of biomarkers of drug response are two major goals of individualized medicine. Here, we developed a deep learning framework called TINDL, completely trained on preclinical cancer cell lines (CCLs), to predict the response of cancer patients to different treatments. TINDL utilizes a tissue-informed normalization to account for the tissue type and cancer type of the tumors and to reduce the statistical disc...
Source: Genomics Proteomics ... - February 12, 2023 Category: Genetics & Stem Cells Authors: David Earl Hostallero Lixuan Wei Liewei Wang Junmei Cairns Amin Emad Source Type: research
MicroRNA-128 suppresses tau phosphorylation and reduces amyloid-beta accumulation by inhibiting the expression of GSK3 β, APPBP2, and mTOR in Alzheimer's disease
CONCLUSION: Our findings suggest that miR-128 suppresses AD pathogenesis, and could be a promising therapeutic target for AD. We also find a possible mechanism underlying the dysregulation of miR-128 in AD, in which Aβ reduces miR-128 expression by inhibiting C/EBPα.PMID:36880288 | DOI:10.1111/cns.14143
Source: CNS Neuroscience and Therapeutics - March 7, 2023 Category: Neuroscience Authors: Siwen Li Chi Him Poon Zhigang Zhang Ming Yue Ruijun Chen Yalun Zhang Md Farhad Hossain Yining Pan Jun Zhao Lei Rong Leung Wing Chu Yat Fung Shea Ekaterina Rogaeva Jie Tu Peter St George-Hyslop Lee Wei Lim You-Qiang Song Source Type: research
Higher-order modular regulation of the human proteome
Mol Syst Biol. 2023 Mar 9:e9503. doi: 10.15252/msb.20209503. Online ahead of print.ABSTRACTOperons are transcriptional modules that allow bacteria to adapt to environmental changes by coordinately expressing the relevant set of genes. In humans, biological pathways and their regulation are more complex. If and how human cells coordinate the expression of entire biological processes is unclear. Here, we capture 31 higher-order co-regulation modules, which we term progulons, by help of supervised machine-learning on proteomics data. Progulons consist of dozens to hundreds of proteins that together mediate core cellular funct...
Source: Mol Biol Cell - March 9, 2023 Category: Molecular Biology Authors: Georg Kustatscher Martina H ödl Edward Rullmann Piotr Grabowski Emmanuel Fiagbedzi Anja Groth Juri Rappsilber Source Type: research
Upregulation of RasGRF1 ameliorates spatial cognitive dysfunction in mice after chronic cerebral hypoperfusion
In this study, we aimed to determine whether changes in the expression of RasGRF1, an important protein associated with cognition and synaptic plasticity, underlie the associated impairments in cognition after CCH. We found that RasGRF1 levels markedly decreased following CCH. Through prediction and validation studies, we observed that miRNA-323-3p was upregulated after CCH and could bind to the 3'-untranslated region of Rasgrf1 mRNA and regulate its expression in vitro. Moreover, the inhibition of miRNA-323-3p upregulated Rasgrf1 expression in the hippocampus after CCH, which was reversed by Rasgrf1 siRNA. This suggests t...
Source: Aging - April 13, 2023 Category: Biomedical Science Authors: Li-Jie Yang Wei Wu Wan-Rong Jiang Cheng-Liang Zhu Zhao-Hui Yao Source Type: research
