MicroRNA-128 suppresses tau phosphorylation and reduces amyloid-beta accumulation by inhibiting the expression of GSK3 β, APPBP2, and mTOR in Alzheimer's disease

CONCLUSION: Our findings suggest that miR-128 suppresses AD pathogenesis, and could be a promising therapeutic target for AD. We also find a possible mechanism underlying the dysregulation of miR-128 in AD, in which Aβ reduces miR-128 expression by inhibiting C/EBPα.PMID:36880288 | DOI:10.1111/cns.14143

Source: CNS Neuroscience and Therapeutics - March 7, 2023 Category: Neuroscience Authors: Siwen Li Chi Him Poon Zhigang Zhang Ming Yue Ruijun Chen Yalun Zhang Md Farhad Hossain Yining Pan Jun Zhao Lei Rong Leung Wing Chu Yat Fung Shea Ekaterina Rogaeva Jie Tu Peter St George-Hyslop Lee Wei Lim You-Qiang Song Source Type: research