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Drug: Taxotere
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Total 178 results found since Jan 2013.
Upregulation of GRIM-19 augments the sensitivity of prostate cancer cells to docetaxel by targeting Rad23b.
This study aims to clarify the potential role and molecular mechanisms of GRIM-19 on the response of PC cells to chemical drug docetaxel. mRNA and protein level of GRIM-19 expression in cells and tissues of PC were measured by quantitative real-time PCR and western blot, respectively. Knock-down of GRIM-19 in PC cells was performed using siRNA. Cell apoptosis was determined by flow cytometric analysis. DNA damage in PC cells was detected by γ-H2AX staining. GRIM-19 was downregulated in PC tissues and cell lines. Knockdown of GRIM-19 increased the resistance of PC cells to docetaxel, and overexpression of GRIM-19 promoted ...
Source: Clinical and Experimental Pharmacology and Physiology - September 16, 2019 Category: Drugs & Pharmacology Authors: Lin H, Shen Z, Liu H, Yang M, Lin J, Luo L, Liu L, Chen H Tags: Clin Exp Pharmacol Physiol Source Type: research
Interfacial properties and micellization of triblock poly(ethylene glycol)-poly(ε-caprolactone)-polyethyleneimine copolymers
This study aimed to explore the link between block copolymers’ interfacial properties and nanoscale carrier formation and found out the influence of length ratio on these characters to optimize drug delivery system. A library of diblock copolymers of PEG-PCL and triblock copolymers with additional PEI (PEG-PCL-PEI) were synthesized. Subsequently, a systematic isothermal investigation was performed to explore molecular arrangements of copolymers at air/water interface. Then, structural properties and drug encapsulation in self-assembly were investigated with DLS, SLS and TEM. We found the additional hydrogen bond in the P...
Source: Acta Pharmaceutica Sinica B - January 20, 2020 Category: Cancer & Oncology Source Type: research
Arctigenin induces necroptosis through mitochondrial dysfunction with CCN1 upregulation in prostate cancer cells under lactic acidosis.
Abstract
Arctigenin, a mitochondrial complex I inhibitor, has been identified as a potential anti-tumor agent, but the involved mechanism still remains elusive. Herein, we studied the underlying mechanism(s) of action of arctigenin on acidity-tolerant prostate cancer PC-3AcT cells in the lactic acid-containing medium. At concentration showing no toxicity on normal prostate epithelial RWPE-1 and HPrEC cells, arctigenin alone or in combination with docetaxel induced significant cytotoxicity in PC-3AcT cells compared to parental PC-3 cells. With arctigenin treatment, reactive oxygen species (ROS) levels, annexin V-PE...
Source: Molecular and Cellular Biochemistry - February 16, 2020 Category: Biochemistry Authors: Lee YJ, Nam HS, Cho MK, Lee SH Tags: Mol Cell Biochem Source Type: research
A Long Noncoding RNA, GAS5 Can Be a Biomarker for Docetaxel Response in Castration Resistant Prostate Cancer
In conclusion, our work suggests that GAS5 can serve as a predictive biomarker for docetaxel response in CRPC; however, the exact mechanism behind the observed correlation remain to be elucidated.
Source: Frontiers in Oncology - May 21, 2021 Category: Cancer & Oncology Source Type: research
Overexpression of claspin promotes docetaxel resistance and is associated with prostate ‐specific antigen recurrence in prostate cancer
Claspin overexpression was related to poor PSA relapse-free prognosis. Claspin knockdown significantly upregulated the sensitivity to docetaxel in DU145 docetaxel-resistant cells. AbstractAlthough docetaxel (DTX) confers significant survival benefits in patients with castration-resistant prostate cancer (CRPC), resistance to DTX inevitably occurs. Therefore, clarifying the mechanisms of DTX resistance may improve survival in patients with CRPC. Claspin plays a pivotal role in DNA replication stress and damage responses and is an essential regulator for the S-phase checkpoint.CLSPN is an oncogenic gene that contributes to t...
Source: Cancer Medicine - July 9, 2021 Category: Cancer & Oncology Authors: Takashi Babasaki,
Kazuhiro Sentani,
Yohei Sekino,
Go Kobayashi,
Quoc Thang Pham,
Narutaka Katsuya,
Shintaro Akabane,
Daiki Taniyama,
Tetsutaro Hayashi,
Masaki Shiota,
Naohide Oue,
Jun Teishima,
Akio Matsubara,
Wataru Yasui Tags: ORIGINAL RESEARCH Source Type: research
ChaC glutathione specific γ-glutamylcyclotransferase 1 inhibits cell viability and increases the sensitivity of prostate cancer cells to docetaxel by inducing endoplasmic reticulum stress and ferroptosis
Exp Ther Med. 2021 Sep;22(3):997. doi: 10.3892/etm.2021.10429. Epub 2021 Jul 15.ABSTRACTThe present study aimed to determine the effects and mechanism of ChaC glutathione specific γ-glutamylcyclotransferase 1 (CHAC1) on cell viability and the sensitivity of prostate cancer cells to docetaxel. Compared with non-tumor human prostate epithelial RWPE-1 cells, the mRNA and protein levels of CHAC1 significantly decreased in two prostate cancer cell lines, DU145 and 22RV1, as measured by quantitative polymerase chain reaction and western blot analysis (P<0.05). The cell viability and glutathione (GSH) levels were significantl...
Source: Experimental and Therapeutic Medicine - August 4, 2021 Category: General Medicine Authors: Saifei He Miao Zhang Ying Ye Juhua Zhuang Xing Ma Yanan Song Wei Xia Source Type: research
Docetaxel-triggered SIDT2/NOX4/JNK/HuR signaling axis is associated with TNF- α-mediated apoptosis of cancer cells
Biochem Pharmacol. 2021 Dec 2:114865. doi: 10.1016/j.bcp.2021.114865. Online ahead of print.ABSTRACTPrevious studies have confirmed that docetaxel (DTX) treatment increases TNF-α production in cancer cells, but its mechanism of action remains unclear. Therefore, this study aimed to determine the signaling axis by which DTX induced the expression of TNF-α in U937 leukemia and MCF-7 breast carcinoma cells. DTX treatment promoted Ca2+-controlled autophagy and SIDT2 expression, resulting in lysosomal degradation of miR-25 in U937 cells. Downregulation of miR-25 increased NOX4 mRNA stability and protein expression. NOX4-stimu...
Source: Biochemical Pharmacology - December 5, 2021 Category: Drugs & Pharmacology Authors: Liang-Jun Wang Jing-Ting Chiou Yuan-Chin Lee Long-Sen Chang Source Type: research
Cancers, Vol. 14, Pages 1877: The Peptide-Drug Conjugate TH1902: A New Sortilin Receptor-Mediated Cancer Therapeutic against Ovarian and Endometrial Cancers
s
Borhane Annabi
Sortilin (SORT1) receptor-mediated endocytosis functions were exploited for this new approach for effective and safe treatments of gynecological cancers. Here, high expression of SORT1 was found in &gt;75% of the clinically annotated ovarian and endometrial tumors analyzed by immunohistochemistry. Therefore, the anticancer properties of the peptide-drug conjugate TH1902, a peptide that targets SORT1 and which is linked to docetaxel molecules, were investigated both in vitro using ovarian and endometrial cancer cell cultures and in vivo using xenograft models. In vitro, TH1902 inhibited cell p...
Source: Cancers - April 8, 2022 Category: Cancer & Oncology Authors: Jean-Christophe Currie Michel Demeule Cyndia Charfi Alain Zgheib Alain Larocque Bogdan Alexandru Danalache Amira Ouanouki Richard B éliveau Christian Marsolais Borhane Annabi Tags: Article Source Type: research
Decreased Expression of HN1 Sensitizes Prostate Cancer Cells to Apoptosis Induced by Docetaxel and 2-Methoxyestradiol
CONCLUSION: HN1 is an anti-apoptotic molecule and inhibits Docetaxel and 2-Methoxyestradiol induced apoptosis by targeting Cyclin B1.PMID:35414498
Source: Annals of Clinical and Laboratory Science - April 13, 2022 Category: Laboratory Medicine Authors: Lokman Varisli Source Type: research
