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Drug: Losartan

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Total 34 results found since Jan 2013.

Mechanisms of AT1a receptor-mediated uptake of angiotensin II by proximal tubule cells: a novel role of the multi-ligand endocytic receptor megalin.
Abstract The present study tested the hypothesis that the multi-ligand endocytic receptor megalin is partially involved in the uptake of angiotensin II (ANG II) and downstream signaling responses in mouse proximal tubule cells (mPCT) by interacting with AT1a receptors. mPCT cells of wild-type (WT) and AT1a receptor-deficient (AT1a-KO) mice were treated with vehicle, the AT1 receptor blocker losartan (10 µM), or a selective megalin siRNA for 48 h. The uptake of fluorescein (FITC)-labeled ANG II (10 nM, 37(o)C) and downstream signaling responses were analyzed by fluorescence imaging and western blot. AT1a receptors...
Source: Am J Physiol Renal P... - April 16, 2014 Category: Urology & Nephrology Authors: Li XC, Zhuo JL Tags: Am J Physiol Renal Physiol Source Type: research

Mechanisms of AT1a receptor-mediated uptake of angiotensin II by proximal tubule cells: a novel role of the multiligand endocytic receptor megalin
The present study tested the hypothesis that the multiligand endocytic receptor megalin is partially involved in the uptake of ANG II and downstream signaling responses in mouse proximal tubule cells (mPCT) by interacting with AT1a receptors. mPCT cells of wild-type (WT) and AT1a receptor-deficient (AT1a-KO) mice were treated with vehicle, the AT1 receptor blocker losartan (10 μM), or a selective megalin small interfering (si) RNA for 48 h. The uptake of fluorescein (FITC)-labeled ANG II (10 nM, 37°C) and downstream signaling responses were analyzed by fluorescence imaging and Western blotting. AT1a receptors and me...
Source: AJP: Renal Physiology - July 15, 2014 Category: Urology & Nephrology Authors: Li, X. C., Zhuo, J. L. Tags: INNOVATIVE METHODOLOGY Source Type: research

Molecular regulation of the expression of leptin by hypoxia in human coronary artery smooth muscle cells
Conclusion: Hypoxia in HCASMCs increases leptin expression through the induction of AngII, ROS, and the JNK pathway to enhance atherosclerosis in HCASMCs.
Source: Journal of Biomedical Science - January 9, 2015 Category: Biomedical Science Authors: Chiung-Zuan ChiuBao-Wei WangKou-Gi Shyu Source Type: research

High Potassium Promotes Mutual Interaction between (Pro)Renin Receptor and the Local Renin-Angiotensin-Aldosterone System in Rat IMCD Cells.
Abstract (Pro)renin receptor (PRR) is predominantly expressed in the collecting duct (CD) with unclear functional implication. It is not known whether CD PRR is regulated by high potassium (HK). Here, we aimed to investigate the effect of HK on PRR expression and its role in regulation of aldosterone synthesis and release in the CD. In primary rat inner medullary CD cells, HK augmented PRR expression and soluble PPR (sPRR) release in a time- and dose- dependent manner, which was attenuated by PRR siRNA, eplerenone, and losartan. HK upregulated aldosterone release in parallel with an increase of CYP11B2 (cytochrome...
Source: Am J Physiol Cell Ph... - August 16, 2016 Category: Cytology Authors: Xu C, Fang H, Zhou L, Lu A, Yang T Tags: Am J Physiol Cell Physiol Source Type: research

Abstract 5109: The CARMA3-Bcl10-MALT1 signalosome mediates NF-{kappa}B activation and cellular invasion in AGTR1-positive breast cancer
Angiotensin II (Ang II) is a potent vasoconstrictor and vascular pro-inflammatory mediator, known classically for its role in promoting arterial dysfunction. Many of these pathogenic effects result from activation of NF-κB in response to stimulation of the type-1 Ang II receptor (AGTR1), a G protein-coupled receptor. We previously discovered that a complex composed of three proteins, CARMA3, Bcl10 and MALT1 (CBM signalosome) mediates AGTR1-dependent activation of NF-κB in vascular cells. Despite its principal role in vascular pathobiology, we recently found that AGTR1 is aberrantly overexpressed in 10-20% of breast cance...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Ekambaram, P., Hubel, N., Lee, J.-Y., Klei, L., Concel, V., Delekta, P., Tomlins, S., McAllister-Lucas, L., Lucas, P. Tags: Tumor Biology Source Type: research

Angiotensin II -induced overexpression of Sirtuin-1 contributes to enhanced expression of Gi α proteins and hyperproliferation of vascular smooth muscle cells
Am J Physiol Heart Circ Physiol. 2021 Jul 16. doi: 10.1152/ajpheart.00898.2020. Online ahead of print.ABSTRACTAngiotensin II (Ang II) plays an important role in the regulation of various physiological functions including proliferation, hypertrophy of vascular smooth muscle cells (VSMC) through the overexpression of Giα proteins. Sirtuin1 (Sirt1), a class III histone deacetylase and epigenetic regulator is implicated in a wide range of cellular functions, including migration and growth of VSMC as well as in Ang II-induced hypertension. The present study was undertaken to examine the role of Sirt1 in Ang II-induced overexpr...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Ekhtear Hossain Yuan Li Madhu B Anand-Srivastava Source Type: research

Sirtuin1 contributes to the overexpression of Giα proteins and hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats
Conclusion: In summary, our results demonstrate that Sirt1 is overexpressed in VSMC from SHR which through augmenting oxidative stress contributes to the enhanced expression of Giα proteins, cell cycle proteins and resultant hyperproliferation of VSMC.
Source: Journal of Hypertension - December 10, 2021 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research

Angiotensin II upregulates KCa3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts.
Abstract The proliferation of cardiac fibroblasts is implicated in the pathogenesis of myocardial remodeling and fibrosis. Intermediate-conductance calcium-activated K(+) channels (KCa3.1 channels) have important roles in cell proliferation. However, it is unknown whether angiotensin II (Ang II), a potent profibrotic molecule, would regulate KCa3.1 channels in cardiac fibroblasts and participate in cell proliferation. In the present study, we investigated whether KCa3.1 channels were regulated by Ang II, and how the channel activity mediated cell proliferation in cultured adult rat cardiac fibroblasts using electr...
Source: Biochemical Pharmacology - May 15, 2013 Category: Drugs & Pharmacology Authors: Wang LP, Wang Y, Zhao LM, Li GR, Deng XL Tags: Biochem Pharmacol Source Type: research

Angiotensin II activation of canonical transient receptor potential‐6 (TRPC6) channels in rat podocytes requires generation of reactive oxygen species
Abstract Angiotensin II (AII) plays a major role in the progression of chronic kidney diseases. Podocytes are essential components of the ultrafiltration apparatus, and are targets for AII signaling. AII has been shown to increase generation of reactive oxygen species (ROS) in podocytes. Canonical transient receptor potential‐6 (TRPC6) channels stimulate Ca2+ influx in podocytes, and have been implicated in glomerular disease. We observed that AII increased cationic currents in rat podocytes in an isolated glomerulus preparation in which podocytes are still attached to the underlying capillary. This effect was completely...
Source: Journal of Cellular Physiology - September 3, 2013 Category: Cytology Authors: Marc Anderson, Hila Roshanravan, Justin Khine, Stuart E. Dryer Tags: Original Research Article Source Type: research

Angiotensin II Activation of TRPC6 Channels in Rat Podocytes Requires Generation of Reactive Oxygen Species
Angiotensin II (AII) plays a major role in the progression of chronic kidney diseases. Podocytes are essential components of the ultrafiltration apparatus, and are targets for AII signaling. AII has been shown to increase generation of reactive oxygen species (ROS) in podocytes. Canonical transient receptor potential‐6 (TRPC6) channels stimulate Ca2+ influx in podocytes, and have been implicated in glomerular disease. We observed that AII increased cationic currents in rat podocytes in an isolated glomerulus preparation in which podocytes are still attached to the underlying capillary. This effect was completely blocked ...
Source: Journal of Cellular Physiology - December 17, 2013 Category: Cytology Authors: Marc Anderson, Hila Roshanravan, Justin Khine, Stuart E. Dryer Tags: Original Research Article Source Type: research