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Condition: Pain

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Total 374 results found since Jan 2013.

ZEB1 Induces Ddr1  Promoter Hypermethylation and Contributes to the Chronic Pain in Spinal Cord in Rats Following Oxaliplatin Treatment
In conclusion, these results suggested that the ZEB1 recruited DNMT3b to the Ddr1 promoter, which induced the DDR1 downregulation and contributed to the oxaliplatin-induced chronic pain.PMID:34032956 | DOI:10.1007/s11064-021-03355-5
Source: Neurochemical Research - May 25, 2021 Category: Neuroscience Authors: Yi-Ying Chen Kai-Sheng Jiang Xiao-Hui Bai Meng Liu Su-Yan Lin Ting Xu Jia-You Wei Dai Li Yuan-Chang Xiong Wen-Jun Xin Zhen-Yu Li Source Type: research

Fragile X mental retardation protein ‐regulated proinflammatory cytokine expression in the spinal cord contributes to the pathogenesis of inflammatory pain induced by complete Freund's adjuvant
AbstractStudies have verified that Fragile X mental retardation protein (FMRP), an RNA-binding protein, plays a potential role in the pathogenesis of formalin- and (RS)-3,5-dihydroxyphenylglycine (DHPG)-induced abnormal pain sensations. However, the role of FMRP in inflammatory pain has not been reported. Here, we showed an increase in FMRP expression in the spinal dorsal horn (SDH) in a rat model of inflammatory pain induced by complete Freund ’s adjuvant (CFA). Double immunofluorescence staining revealed that FMRP was mainly expressed in spinal neurons and colocalized with proinflammatory cytokines [tumor necrosis fact...
Source: Journal of Neurochemistry - August 2, 2021 Category: Neuroscience Authors: Yixin Yang, Jinsong Zhao, Yunze Li, Xiangyao Li, Xiaowei Chen, Zhiying Feng Tags: ORIGINAL ARTICLE Source Type: research

The role of dorsal root ganglia alpha-7 nicotinic acetylcholine receptor in complete Freund ’s adjuvant-induced chronic inflammatory pain
ConclusionsThe findings of this study suggest that α7 nAChR may be potentially utilized as a therapeutic target for therapeutics of chronic inflammatory pain.
Source: Inflammopharmacology - September 12, 2021 Category: Drugs & Pharmacology Source Type: research

LncRNA MRAK159688 facilitates morphine tolerance by promoting REST-mediated inhibition of mu opioid receptor in rats
Neuropharmacology. 2022 Jan 1;206:108938. doi: 10.1016/j.neuropharm.2021.108938. Online ahead of print.ABSTRACTMorphine tolerance (MT) caused by the long-term use of morphine is a major medical problem. The molecular mechanism of morphine tolerance remains elusive. Here, we established a morphine tolerance model in rats and verified whether the long noncoding RNA (lncRNA) MRAK159688 is involved in morphine tolerance and its specific molecular mechanism. We show the significant upregulation of MRAK159688 expression in the spinal cord of morphine-tolerant rats. Overexpression of MRAK159688 by a lentivirus reduces the analges...
Source: Neuropharmacology - January 4, 2022 Category: Drugs & Pharmacology Authors: Meiling Deng Zengli Zhang Manyu Xing Xia Liang Zhengyiqi Li Jing Wu Shasha Jiang Yingqi Weng Qulian Guo Wangyuan Zou Source Type: research

Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII
In conclusion, HSYA could attenuate oxidative stress injury and apoptosis induced by TBHP in the NP cell line, and could improve the regulation of ECM balance.PMID:35069863 | PMC:PMC8764902 | DOI:10.3892/etm.2021.11105
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shuo Yang Wenbo Liao Source Type: research

Metformin Relieves Bortezomib-Induced Neuropathic Pain by Regulating AMPKa2-Mediated Autophagy in the Spinal Dorsal Horn
Neurochem Res. 2022 Mar 12. doi: 10.1007/s11064-022-03571-7. Online ahead of print.ABSTRACTChemotherapy-induced neuropathic pain is a major clinical problem with limited treatment options. Here, we show that metformin relieves bortezomib (BTZ)-evoked induction and maintenance of neuropathic pain by preventing the reduction in the expression of Beclin-1, an autophagy marker, in the spinal dorsal horn. Application of rapamycin or 3-methyladenine, autophagy inducer and inhibitor, respectively, affected the mechanical allodynia differently. Co-application of 3-methyladenine and metformin partially inhibited the effect of metfo...
Source: Neurochemical Research - March 12, 2022 Category: Neuroscience Authors: Meng Liu Yu-Ting Zhao You-You Lv Ting Xu Dai Li Yuan-Chang Xiong Wen-Jun Xin Su-Yan Lin Source Type: research

Downregulation of nuclear STAT2 protein in the spinal dorsal horn is involved in neuropathic pain following chronic constriction injury of the rat sciatic nerve
In this study, we investigated whether the transcription factor STAT2 affects neuropathic pain and evaluated its possible mechanisms. A proteomic analysis showed that the nuclear fraction of STAT2 protein in the SDH was downregulated after chronic constriction injury of the rat sciatic nerve, which was associated with the development of neuropathic pain. Similarly, siRNA-induced downregulation of STAT2 in the SDH of naïve rats also resulted in pain hypersensitivity. Using RNA-sequencing analysis, we showed that reduction of nuclear STAT2 after chronic constriction injury was associated with increased expression of microgl...
Source: Frontiers in Pharmacology - January 18, 2023 Category: Drugs & Pharmacology Source Type: research