• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Transforming growth factor ‑β1 functions as a competitive endogenous RNA that ameliorates intracranial hemorrhage injury by sponging microRNA‑93‑5p
Mol Med Rep. 2021 Jul;24(1):499. doi: 10.3892/mmr.2021.12138. Epub 2021 May 6.ABSTRACTIntracerebral hemorrhage (ICH) has the highest mortality rate of all stroke subtypes but an effective treatment has yet to be clinically implemented. Transforming growth factor‑β1 (TGF‑β1) has been reported to modulate microglia‑mediated neuroinflammation after ICH and promote functional recovery; however, the underlying mechanisms remain unclear. Non‑coding RNAs such as microRNAs (miRNAs) and competitive endogenous RNAs (ceRNAs) have surfaced as critical regulators in human disease. A known miR‑93 target, nuclear factor eryth...
Source: Molecular Medicine Reports - May 6, 2021 Category: Molecular Biology Authors: Han Wang Xianming Cao Xiaoqing Wen Dongling Li Yetong Ouyang Bing Bao Yuqin Zhong Zhengfang Qin Min Yin Zhiying Chen Xiaoping Yin Source Type: research

Isorhynchophylline Relieves Ferroptosis-Induced Nerve Damage after Intracerebral Hemorrhage Via miR-122-5p/TP53/SLC7A11 Pathway
In this study, mouse hippocampal HT-22 cells were treated with ferric ammonium citrate (FAC) alone or together with IRN, and we found IRN reduced the FAC-induced cell damage. Then, cells were treated with IRN following treatment with FAC after transfection with miR-122-5p inhibitor, and the results showed IRN reduced the FAC-induced decrease of miR-122-5p levels and relieved the ferroptosis by detecting ferroptotic marker proteins, iron ion concentration and oxidative stress level; after transfection with miR-122-5p inhibitor, the protective effects of IRN against FAC-induced ferroptosis in these cells were weakened. TP53 ...
Source: Neurochemical Research - May 4, 2021 Category: Neuroscience Authors: Haikang Zhao Xiaoqiang Li Lei Yang Liang Zhang Xiaobing Jiang Wenwen Gao Peng Chen Yingying Cheng Fenglu Wang Jianrong Liu Source Type: research

Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1 α pathway in rats
Conclusions: The activation of MC1R with BMS-470539 significantly attenuated EBI after SAH by suppressing the oxidative stress, apoptosis, and mitochondrial fission through the AMPK/SIRT1/PGC-1α signaling pathway.
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Weilin Xu, Jun Yan, Umut Ocak, Cameron Lenahan, Anwen Shao, Jiping Tang, Jianmin Zhang, John H. Zhang Tags: Research Paper Source Type: research

The AMPAR antagonist perampanel protects the neurovascular unit against traumatic injury via regulating Sirt3.
CONCLUSION: Our results indicate that the noncompetitive AMPAR antagonist perampanel protects the NVU system and reduces brain damage after TBI via activating the Sirt3 cascades. PMID: 33421349 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - January 9, 2021 Category: Neuroscience Authors: Chen T, Liu WB, Qian X, Xie KL, Wang YH Tags: CNS Neurosci Ther Source Type: research

Tyrosine kinase Fyn promotes apoptosis after intracerebral hemorrhage in rats by activating Drp1 signaling
This study clarifies the relationship between Fyn, apoptosis, and inflammation following ICH and provides a new strategy for explo ring the prevention and treatment of ICH.Key messagesICH induced an increase in Fyn expression in human and rat cerebral tissues.Knockdown of Fyn prevented cerebral damage following ICH.Inhibition of Fyn had no significant effects on inflammatory responses. However, the downregulation of Fyn exerted neuroprotective effects on apoptosis.Fyn perturbed ICH-induced cell apoptosis by interacting with and phosphorylating (Ser616) Drp1 in a rat ICH model.
Source: Journal of Molecular Medicine - January 6, 2021 Category: Molecular Biology Source Type: research

Activation of adenosine A3 receptor reduces early brain injury by alleviating neuroinflammation after subarachnoid hemorrhage in elderly rats.
This study aimed to investigate the effects of A3 adenosine receptors (A3R) activation on neurofunction and microglial phenotype polarization in the context of SAH in aged rats. The A3R agonist (CI-IB-MECA) and antagonist (MRS1523) were used in the SAH model. Microglia were cultured to mimic SAH in the presence or absence of CI-IB-MECA and/or siRNA for A3R. The neurofunction and status of the microglial phenotype were evaluated. The P38 inhibitor SB202190 and the STAT6 inhibitor AS1517499 were used to explore the signaling pathway. The results showed that SAH induced microglia to polarize to the M(LPS) phenotype both in vi...
Source: Aging - November 30, 2020 Category: Biomedical Science Authors: Li P, Li X, Deng P, Wang D, Bai X, Li Y, Luo C, Belguise K, Wang X, Wei X, Xia Z, Yi B Tags: Aging (Albany NY) Source Type: research

MFG-E8 attenuates inflammation in subarachnoid hemorrhage by driving microglial M2 polarization.
Abstract Increasing evidence suggests that microglial polarization plays an important role in the pathological processes of neuroinflammation following subarachnoid hemorrhage (SAH). Previous studies indicated that milk fat globule-epidermal growth factor-8 (MFG-E8) has potential anti-apoptotic and anti-inflammatory effects in cerebral ischemia. However, the effects of MFG-E8 on microglial polarization have not been evaluated after SAH. Therefore, the aim of this study was to explore the role of MFG-E8 in anti-inflammation, and its effects on microglial polarization following SAH. We established the SAH model via ...
Source: Experimental Neurology - November 24, 2020 Category: Neurology Authors: Gao Y, Tao T, Wu D, Zhuang Z, Lu Y, Wu L, Liu G, Zhou Y, Zhang D, Wang H, Dai W, Li W, Hang CH Tags: Exp Neurol Source Type: research

Tim-3 deteriorates neuroinflammatory and neurocyte apoptosis after subarachnoid hemorrhage through the Nrf2/HMGB1 signaling pathway in rats.
Abstract Inflammation is known to play an important role in early brain injury (EBI) after subarachnoid hemorrhage (SAH). T cell immunoglobulin and mucin domain-3 (Tim-3) has emerged as a critical regulator of adaptive and innate immune responses, and has been identified to play a vital role in certain inflammatory diseases; The present study explored the effect of Tim-3 on inflammatory responses and detailed mechanism in EBI following SAH. We investigated the effects of Tim-3 on SAH models established by endovascular puncture method in Sprague-Dawley rats. The present studies revealed that SAH induced a significa...
Source: Aging - November 7, 2020 Category: Biomedical Science Authors: Guo S, Li Y, Wei B, Liu W, Li R, Cheng W, Zhang X, He X, Li X, Duan C Tags: Aging (Albany NY) Source Type: research

Transcription of CLDND1 in human brain endothelial cells is regulated by the myeloid zinc finger protein 1.
Abstract Increased permeability of endothelial cells lining the blood vessels in the brain leads to vascular oedema and, potentially, to stroke. The tight junctions (TJs), primarily responsible for the regulation of vascular permeability, are multi-protein complexes comprising the claudin family of proteins and occludin. Several studies have reported that downregulation of the claudin domain containing 1 (CLDND1) gene enhances vascular permeability, which consequently increases the risk of stroke. However, the transcriptional regulation of CLDND1 has not been studied extensively. Therefore, this study aimed to ide...
Source: Clinical and Experimental Pharmacology and Physiology - October 9, 2020 Category: Drugs & Pharmacology Authors: Shima A, Matsuoka H, Yamaoka A, Michihara A Tags: Clin Exp Pharmacol Physiol Source Type: research

Pages: 1  2  3  4  5  6  7  8