Tyrosine kinase Fyn promotes apoptosis after intracerebral hemorrhage in rats by activating Drp1 signaling

This study clarifies the relationship between Fyn, apoptosis, and inflammation following ICH and provides a new strategy for explo ring the prevention and treatment of ICH.Key messagesICH induced an increase in Fyn expression in human and rat cerebral tissues.Knockdown of Fyn prevented cerebral damage following ICH.Inhibition of Fyn had no significant effects on inflammatory responses. However, the downregulation of Fyn exerted neuroprotective effects on apoptosis.Fyn perturbed ICH-induced cell apoptosis by interacting with and phosphorylating (Ser616) Drp1 in a rat ICH model.
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research