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Condition: Glaucoma

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Total 87 results found since Jan 2013.

Long non-coding RNA GAS5 contributed to the development of glaucoma via regulating the TGF- β signaling pathway.
CONCLUSIONS: In our study, we found that down-regulation of lncRNA GAS5 may maintain retinal ganglion cell survival in glaucoma through the activation of TGF-β pathway to promote cell proliferation and differentiation. PMID: 29509235 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - March 8, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Beta2 adrenergic receptor silencing change intraocular pressure in New Zealand rabbits
Conclusion The use of siRNA against the beta2 adrenergic receptors could provide an interesting therapeutic strategy for glaucoma treatment.
Source: Journal of Optometry - November 11, 2017 Category: Opthalmology Source Type: research

Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells
Glaucoma, a leading cause of irreversible blindness, is commonly associated with elevated intraocular pressure (IOP) due to impaired aqueous humor (AH) drainage through the trabecular meshwork (TM). Although dysregulated production and organization of extracellular matrix (ECM) is presumed to increase resistance to AH outflow and elevate IOP by altering TM cell contractile and adhesive properties, it is not known whether regulation of ECM protein phosphorylation via the secretory vertebrate lonesome kinase (VLK) influences TM cellular characteristics. Here, we tested this possibility. Experiments carried out in this study ...
Source: Journal of Cellular Physiology - March 27, 2017 Category: Cytology Authors: Rupalatha Maddala, Nikolai P. Skiba, Ponugoti Vasantha Rao Tags: Original Research Article Source Type: research

Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape and Adhesion in Trabecular Meshwork Cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - September 4, 2016 Category: Cytology Authors: Rupalatha Maddala, Nikolai P. Skiba, Ponugoti Vasantha Rao Tags: Original Research Article Source Type: research

Gene transfer to the outflow tract.
Abstract Elevated intraocular pressure is the primary cause of open angle glaucoma. Outflow resistance exists within the trabecular meshwork but also at the level of Schlemm's canal and further downstream within the outflow system. Viral vectors allow to take advantage of naturally evolved, highly efficient mechanisms of gene transfer, a process that is termed transduction. They can be produced at biosafety level 2 in the lab using protocols that have evolved considerably over the last 15-20 years. Applied by an intracameral bolus, vectors follow conventional as well as uveoscleral outflow pathways. They may affec...
Source: Experimental Eye Research - April 26, 2016 Category: Opthalmology Authors: Dang Y, Loewen R, Parikh HA, Roy P, Loewen NA Tags: Exp Eye Res Source Type: research

Crosstalk between TGFβ and Wnt signaling pathways in the human trabecular meshwork.
In this study, we determined whether there is a crosstalk between the TGFβ/Smad pathway and the canonical Wnt pathway using luciferase reporter assays. Lentiviral luciferase reporter vectors for studying the TGFβ/Smad pathway or the canonical Wnt pathway were transduced into primary human non-glaucomatous TM (NTM) cells. Cells were treated with or without a combination of 5 μg/ml TGFβ2 and/or 100 ng/ml Wnt3a recombinant proteins, and luciferase levels were measured using a plate reader. We found that TGFβ2 inhibited Wnt3a-induced canonical Wnt pathway activation, while Wnt3a inhibited TGFβ2-induced TGFβ/Smad pathw...
Source: Experimental Eye Research - April 13, 2016 Category: Opthalmology Authors: Webber HC, Bermudez JY, Sethi A, Clark AF, Mao W Tags: Exp Eye Res Source Type: research

Evaluation of Adenovirus-Mediated Down-Regulation of Connective Tissue Growth Factor on Postoperative Wound Healing After Experimental Glaucoma Surgery.
CONCLUSIONS: Down-regulation of CTGF is effective in inhibiting postoperative scarring in vivo. This suggests that RNAi with CTGF siRNA may potentially pave the road for a novel therapeutic strategy to improve glaucoma surgery results. PMID: 26554857 [PubMed - as supplied by publisher]
Source: Current Eye Research - November 10, 2015 Category: Opthalmology Authors: Lim DH, Kim TE, Kee C Tags: Curr Eye Res Source Type: research

Downregulation of microRNA-100 protects apoptosis and promotes neuronal growth in retinal ganglion cells
Conclusion: Down-regulating miR-100 is an effective method to protect H2O2 induced apoptosis in RGC-5 cells, possible associated with IGF1R regulation.
Source: BMC Molecular Biology - November 18, 2014 Category: Molecular Biology Authors: Ning KongXiaohe LuBin Li Source Type: research

Latent TGF-{beta} binding protein-2 is essential for the development of ciliary zonule microfibrils
In this study, we explore the in vivo function of LTBP-2 by generating Ltbp2–/– mice. Ltbp2–/– mice survived to adulthood but developed lens luxation caused by compromised ciliary zonule formation without a typical phenotype related to glaucoma, suggesting that LTBP-2 deficiency primarily causes lens dislocation but not glaucoma. The suppression of LTBP2 expression in cultured human ciliary epithelial cells by siRNA disrupted the formation of the microfibril meshwork by the cells. Supplementation of recombinant LTBP-2 in culture medium not only rescued the microfibril meshwork formation in LTBP2-sup...
Source: Human Molecular Genetics - October 8, 2014 Category: Genetics & Stem Cells Authors: Inoue, T., Ohbayashi, T., Fujikawa, Y., Yoshida, H., Akama, T. O., Noda, K., Horiguchi, M., Kameyama, K., Hata, Y., Takahashi, K., Kusumoto, K., Nakamura, T. Tags: ARTICLES Source Type: research

Dexamethasone Increases Cdc42 Expression in Human TM-1 Cells.
Conclusions: DEX increases Cdc42 expression in TM-1. This may represent a potential mechanism of DEX-induced HTM cytoskeletal rearrangement. PMID: 24871483 [PubMed - as supplied by publisher]
Source: Current Eye Research - May 28, 2014 Category: Opthalmology Authors: Qiu X, Wu K, Lin X, Liu Q, Ye Y, Yu M Tags: Curr Eye Res Source Type: research

Lithium chloride inhibits TGF-β1-induced myofibroblast transdifferentiation via PI3K/Akt pathway in cultured fibroblasts from Tenon's capsule of the human eye.
Abstract Excess scarring of the conjunctiva after glaucoma filtration surgery is a major cause of failure. Transforming growth factor (TGF)-β is critically involved in post-operative scarring. Lithium inhibits TGF-β-induced gene protein expression in corneal fibroblasts and inhibits TGF-β-induced epithelial mesenchymal transition. Here, we investigated the effects of LiCl on TGF-β1-mediated signaling pathways and on myofibroblast transdifferentiation of human Tenon's capsule fibroblasts (HTFs). LiCl treatment reduced expression of TGF-β1-induced α-SMA expression in HTFs. LiCl also decreased Akt phosphorylati...
Source: Biotechnology Letters - February 22, 2014 Category: Biotechnology Authors: Chung EJ, Sohn YH, Kwon SH, Jung SA, Lee JH Tags: Biotechnol Lett Source Type: research

Activated {alpha}v{beta}3 Integrin Regulates {alpha}v{beta}5 Integrin-Mediated Phagocytosis in Trabecular Meshwork Cells Glaucoma
Conclusions. The αvβ5 integrin-FAK–mediated pathway regulates phagocytosis in TM cells and this pathway is inhibited by activation of αvβ3 integrins. This suggests that changes in integrin expression and activity may be responsible for alterations in phagocytosis observed in steroid induced glaucoma.
Source: Investigative Ophthalmology - July 24, 2013 Category: Opthalmology Authors: Gagen, D., Filla, M. S., Clark, R., Liton, P., Peters, D. M. Tags: Glaucoma Source Type: research