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Total 44 results found since Jan 2013.

Proteomic Analysis and Functional Studies of Baicalin on Proteins Associated with Skin Cancer.
Abstract Abundant evidence supports the key role of ultraviolet radiation (UVR) in skin cancer development. The human skin, especially the epidermal layer, is the main defense against UV radiation. Baicalin is a major bioactive component of Scutellaria baicalensis Georgi, a plant which has been found to exhibit antitumor activity. The anticarcinogenic mechanism of baicalin is not completely understood. We have reported that baicalin inhibited UVB-induced photo-damage and apoptosis in HaCaT cells (human skin keratinocytes). The aim of the present study is to investigate the cellular gene targets responsible for bai...
Source: The American Journal of Chinese Medicine - April 6, 2017 Category: Complementary Medicine Authors: Li D, Lin B, Yusuf N, Burns EM, Yu X, Luo D, Min W Tags: Am J Chin Med Source Type: research

Upregulation of PIM2 by Underexpression of MicroRNA-135-5p Improves Survival Rates of Skin Allografts by Suppressing Apoptosis of Fibroblast Cells.
CONCLUSIONS MiR-135-5p is involved with the prognosis of burn patients after skin transplantation. PIM2 is a virtual target of miR-135-5p, and there is a negative regulatory relationship between miR-135-5p and PIM2. MiR-135-5p and PIM2 interfered with the viability and apoptosis in cells. PMID: 28064305 [PubMed - in process]
Source: Medical Science Monitor - January 13, 2017 Category: Research Tags: Med Sci Monit Source Type: research

miR-21 promotes collagen production in keloid via Smad7
Conclusions miR-21 promoted collagen production in keloid by negatively regulating the expression of the Smad7.
Source: Burns - October 4, 2016 Category: Dermatology Source Type: research

Effect of tumor necrosis factor-induced protein 8 on T-cell-mediated immunity in mice after thermal injury.
Authors: Xin Y, Wan DH, Wang X, Gao XJ, Xu XJ, Ju XL, Li AM Abstract Tumor necrosis factor-induced protein 8(TNFAIP8), the first identified member of the TNFAIP8 family, shares considerable sequence homology with members of this family. It is expressed in a wide variety of human normal tissues, with relatively higher levels in lymphoid tissues and placenta. The present study was designed to examine the effect of TNFAIP8 on T-cell-mediated immunity secondary to burn injury. Sixty male mice were randomly divided into four groups as follows: sham burn group, burn group, burn with TNFAIP8-siRNA transfection group, and ...
Source: Journal of Biological Regulators and Homeostatic Agents - September 23, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

GSE72055 Human telomerase RNA processing and quality control
Contributors : Chi K Tang ; Hui F Wang ; Allison M Burns ; Morgan R Schroeder ; Martina Gaspari ; Peter BaumannSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA sequencing of HeLa cells treated with siRNA against the RNA exosome components hRRP40, hRRP6, hDIS3, and hRRP6/hDIS3 or the splicing inhibitors Isoginkgetin and spliceostatin A, respectively.
Source: GEO: Gene Expression Omnibus - November 25, 2015 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Systematic screening identifies dual PI3K and mTOR inhibition as a conserved therapeutic vulnerability in osteosarcoma.
CONCLUSIONS: The approaches described here have identified dual inhibition of the PI3K/mTOR pathway as a sensitive, druggable target in OS and provide rationale for translational studies with these agents. PMID: 25862761 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - April 10, 2015 Category: Cancer & Oncology Authors: Gupte A, Baker E, Wan SS, Stewart E, Loh A, Shelat AA, Gould CM, Chalk A, Taylor S, Lackovic K, Karlstrom A, Mutsaers A, Desai J, Madhamshettiwar PB, Zannettino AC, Burns C, Huang DC, Dyer M, Simpson KJ, Walkley C Tags: Clin Cancer Res Source Type: research

Dexamethasone downregulates caveolin-1 causing muscle atrophy via inhibited insulin signaling
In this study, we report a new pathway in which glucocorticoids reduce the levels of upstream insulin signaling components by downregulating the transcription of the gene encoding caveolin-1 (CAV1), a scaffolding protein present in the caveolar membrane. Treatment with the glucocorticoid dexamethasone (DEX) decreased CAV1 protein and Cav1 mRNA expression, with a concomitant reduction in insulin receptor alpha (IRα) and IR substrate 1 (IRS1) levels in C2C12 myotubes. On the basis of the results of promoter analysis using deletion mutants and site-directed mutagenesis a negative glucocorticoid-response element in the r...
Source: Journal of Endocrinology - March 19, 2015 Category: Endocrinology Authors: Son, Y. H., Lee, S.-J., Lee, K.-B., Lee, J.-H., Jeong, E. M., Chung, S. G., Park, S.-C., Kim, I.-G. Tags: Research Source Type: research

Nucleolin Enhances the Proliferation and Migration of Heat‐denatured Human Dermal Fibroblasts
This article is protected by copyright. All rights reserved.
Source: Wound Repair and Regeneration - March 1, 2015 Category: Surgery Authors: Bimei Jiang, Yuanbin Li, Pengfei Liang, Yanjuan Liu, Xu Huang, Zhongyi Tong, Pihong Zhang, Xiaoyuan Huang, Ying Liu, Zhenguo Liu Tags: Original Research–Basic Science Source Type: research

Nestin-mediated cytoskeletal remodeling in endothelial cells: novel mechanistic insight into VEGF-induced cell migration in angiogenesis
Nestin is highly expressed in poorly differentiated and newly formed proliferating endothelial cells (ECs); however, the role of this protein in angiogenesis remains unknown. Additionally, the cytoskeleton and associated cytoskeleton-binding proteins mediate the migration of vascular ECs. Therefore, the aim of the present study was to determine whether VEGF regulates the cytoskeleton, as well as other associated proteins, to promote the migration of vascular ECs. The coexpression of nestin and CD31 during angiogenesis in alkali-burned rat corneas was examined via immunohistochemical analysis. Western blot analyses revealed...
Source: AJP: Cell Physiology - March 1, 2015 Category: Cytology Authors: Liang, Z.-w., Wang, Z., Chen, H., Li, C., Zhou, T., Yang, Z., Yang, X., Yang, Y., Gao, G., Cai, W. Tags: CALL FOR PAPERS Source Type: research

MicroRNA miR-466 inhibits Lymphangiogenesis by targeting prospero-related homeobox 1 in the alkali burn corneal injury model
Conclusions: Our data suggest that miR-446 may have a protective effect on transplanted corneas by suppressing Prox1 expression at the post-transcriptional level. The results of the current study may provide insights into the mechanisms of lymphangiogenesis resulting from corneal graft rejection and alkali-burn injuries, as well as into the development of new treatments for lymphangiogenic eye diseases.
Source: Journal of Biomedical Science - January 2, 2015 Category: Biomedical Science Authors: Minkoo SeoJun-Sub ChoiChang RhoChoun-Ki JooSuk Lee Source Type: research

Nestin-Mediated Cytoskeleton Remodeling in Endothelial Cells: a Novel Mechanistic Insight into VEGF-Induced Cell Migration in Angiogenesis.
Abstract Although nestin is highly expressed in poorly differentiated or newly formed proliferating ECs (endothelial cells), the role of this protein in angiogenesis remains unknown. In addition, the cytoskeleton and associated cytoskeleton-binding proteins mediate the migration of vascular endothelial cells. Thus, the aim of the present study was to determine whether VEGF regulates the cytoskeleton or other associated proteins to promote the migration of VECs.Nestin co-expression with CD31 during angiogenesis in alkali-burned rats corneas was examined through immunohistochemical analysis. Western blot analyses re...
Source: American Journal of Physiology. Cell Physiology - December 10, 2014 Category: Cytology Authors: Liang ZW, Wang Z, Chen H, Li C, Zhou T, Yang Z, Yang X, Yang Y, Gao G, Cai W Tags: Am J Physiol Cell Physiol Source Type: research

Adeno-associated virus type 8 vector-mediated expression of siRNA targeting vascular endothelial growth factor efficiently inhibits neovascularization in a murine choroidal neovascularization model.
CONCLUSIONS: These results suggest that siRNA-VEGF can be expressed across the retina and that long-term suppression of CNV is possible through the use of stable AAV2/8-mediated siRNA-VEGF expression. In vivo gene therapy may thus be a feasible approach to the clinical management of CNV in conditions such as age-related macular degeneration. PMID: 24744609 [PubMed - indexed for MEDLINE]
Source: Molecular Vision - November 16, 2014 Category: Molecular Biology Tags: Mol Vis Source Type: research

Reliability of the Mouse Model of Choroidal Neovascularization Induced by Laser Photocoagulation Retina
Conclusions. We present our recommended methods for conducting experiments with the mouse laser-induced CNV model to enhance reproducibility and minimize investigator bias.
Source: Investigative Ophthalmology - October 16, 2014 Category: Opthalmology Authors: Poor, S. H., Qiu, Y., Fassbender, E. S., Shen, S., Woolfenden, A., Delpero, A., Kim, Y., Buchanan, N., Gebuhr, T. C., Hanks, S. M., Meredith, E. L., Jaffee, B. D., Dryja, T. P. Tags: Retina Source Type: research

Sphingomyelin synthase 1 activity is regulated by the BCR-ABL oncogene Research Articles
Sphingomyelin synthase (SMS) produces sphingomyelin while consuming ceramide (a negative regulator of cell proliferation) and forming diacylglycerol (DAG) (a mitogenic factor). Therefore, enhanced SMS activity could favor cell proliferation. To examine if dysregulated SMS contributes to leukemogenesis, we measured SMS activity in several leukemic cell lines and found that it is highly elevated in K562 chronic myelogenous leukemia (CML) cells. The increased SMS in K562 cells was caused by the presence of Bcr-abl, a hallmark of CML; stable expression of Bcr-abl elevated SMS activity in HL-60 cells while inhibition of the tyr...
Source: The Journal of Lipid Research - February 12, 2013 Category: Lipidology Authors: Burns, T. A., Subathra, M., Signorelli, P., Choi, Y., Yang, X., Wang, Y., Villani, M., Bhalla, K., Zhou, D., Luberto, C. Tags: Research Articles Source Type: research