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Phosphate NIMA-Related Kinase 2-Dependent Epigenetic Pathways in Dorsal Root Ganglion Neurons Mediates Paclitaxel-Induced Neuropathic Pain
CONCLUSIONS: pRSK2/JMJD3/H3K27me3/TRPV1 signaling in the DRG neurons plays as a key regulator for PTX therapeutic approaches.PMID:36753440 | DOI:10.1213/ANE.0000000000006397
Source: Anesthesia and Analgesia - February 8, 2023 Category: Anesthesiology Authors: Ming-Chun Hsieh Cheng-Yuan Lai Wen-Long Cho Li-Ting Lin Chou-Ming Yeh Po-Sheng Yang Jen-Kun Cheng Hsueh-Hsiao Wang Kuan-Hung Lin Siao-Tong Nie Tzer-Bin Lin Hsien-Yu Peng Source Type: research

Bupivacaine Induces ROS-Dependent Autophagic Damage in DRG Neurons via TUG1/mTOR in a High-Glucose Environment
Neurotox Res. 2022 Jan 18. doi: 10.1007/s12640-021-00461-8. Online ahead of print.ABSTRACTBupivacaine (BP) is a commonly clinically used local anesthetic (LA). Current studies suggest that neurological complications are increased in diabetic patients after LA application, but the molecular mechanism is poorly understood. LA-induced autophagy and neuronal injury have been reported. We hypothesized that a high-glucose environment aggravates BP-induced autophagic damage. Mouse dorsal root ganglion (DRG) neurons were treated with BP in a high-glucose environment, and the results showed that reactive oxygen species (ROS) levels...
Source: Cell Research - January 19, 2022 Category: Cytology Authors: Luying Lai Yongwei Wang Shenghui Peng Wenjing Guo Guanshan Wei Le Li Zhengyuan Xia Fengxian Li Shiyuan Xu Source Type: research

Small-molecule GSK-3 inhibitor rescued apoptosis and neurodegeneration in anesthetics-injured dorsal root ganglion neurons
Conclusions GSK-3 inhibitor SB216763, through PKC, is effective in protecting anesthetics-induced neurotoxicity in DRG.
Source: Biomedicine and Pharmacotherapy - September 23, 2016 Category: Drugs & Pharmacology Source Type: research

Small-molecule GSK-3 inhibitor rescued apoptosis and neurodegeneration in anesthetics-injured dorsal root ganglion neurons.
CONCLUSIONS: GSK-3 inhibitor SB216763, through PKC, is effective in protecting anesthetics-induced neurotoxicity in DRG. PMID: 27668540 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 22, 2016 Category: Drugs & Pharmacology Authors: Yu T, Lin W Tags: Biomed Pharmacother Source Type: research

Contribution of the Suppressor of Variegation 3-9 Homolog 1 in Dorsal Root Ganglia and Spinal Cord Dorsal Horn to Nerve Injury –induced Nociceptive Hypersensitivity
Conclusions The findings of this study suggest that SUV39H1 contributes to nerve injury –induced allodynia and hyperalgesia through gating MOR expression in the injured DRG. SUV39H1 may be a potential target for the therapeutic treatment of nerve injury–induced nociceptive hypersensitivity.
Source: Anesthesiology - September 20, 2016 Category: Anesthesiology Source Type: research

Inhibition of long non-coding RNA IGF2AS has profound effect on inducing neuronal growth and protecting local-anesthetic induced neurotoxicity in dorsal root ganglion neurons
Conclusions Inhibiting endogenous IGF2AS may promote neuronal growth and protect local-anesthetic induced neurotoxicity in DRG neurons, possibly through complimentary IGF2 upregulation and autocrine activation neurotrophin genes.
Source: Biomedicine and Pharmacotherapy - May 17, 2016 Category: Drugs & Pharmacology Source Type: research

Amitriptyline Activates TrkA to Aid Neuronal Growth and Attenuate Anesthesia-Induced Neurodegeneration in Rat Dorsal Root Ganglion Neurons
Abstract: Tricyclic antidepressant amitriptyline (AM) has been shown to exert neurotrophic activity on neurons. We thus explored whether AM may aid the neuronal development and protect anesthesia-induced neuro-injury in young spinal cord dorsal root ganglion (DRG) neurons. The DRG explants were prepared from 1-day-old rats. The effect of AM on aiding DRG neural development was examined by immunohistochemistry at dose-dependent manner. AM-induced changes in gene and protein expressions, and also phosphorylation states of tyrosine kinases receptor A (TrkA) and B (TrkB) in DRG, were examined by quantitative real-time polymer...
Source: Medicine - May 1, 2016 Category: Internal Medicine Tags: Research Article: Meta-Analysisof Observ Studiesin Epidemiology Source Type: research

Long noncoding RNA BDNF-AS protects local anesthetic induced neurotoxicity in dorsal root ganglion neurons.
CONCLUSIONS: BDNF-AS downregulation rescued local anesthetic-induce neurotoxicity in DRG neurons, probably through the activation of neurotrophin TrkB signaling pathway. PMID: 27133058 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2016 Category: Drugs & Pharmacology Authors: Zhang Y, Yan L, Cao Y, Kong G, Lin C Tags: Biomed Pharmacother Source Type: research

Long noncoding RNA BDNF-AS protects local anesthetic induced neurotoxicity in dorsal root ganglion neurons
Conclusions BDNF-AS downregulation rescued local anesthetic-induce neurotoxicity in DRG neurons, probably through the activation of neurotrophin TrkB signaling pathway.
Source: Biomedicine and Pharmacotherapy - March 28, 2016 Category: Drugs & Pharmacology Source Type: research

Downregulation of miR-210 protected bupivacaine-induced neurotoxicity in dorsal root ganglion.
In this study, we examined the molecular mechanisms of microRNA-210 (miR-210) in regulating bupivacaine-induced dorsal root ganglia (DRG) neurotoxicity in vitro. Young mouse (P30) DRG explants were cultured in vitro and treated with 5 mM bupivacaine to induce neurotoxicity. QRT-PCR was used to evaluate the expression profiles of miRNAs within 24 h after bupivacaine treatment. MiR-210 was downregulated in DRG, and its effects on bupivacaine-induced neurotoxicity were evaluated by apoptosis and neurite growth assays, respectively. Putative downstream target of miR-210 in DRG, BDNF, was evaluated by dual-luciferase assay, q...
Source: Experimental Brain Research - December 26, 2015 Category: Neuroscience Authors: Wang Y, Ni H, Zhang W, Wang X, Zhang H Tags: Exp Brain Res Source Type: research

Isoflurane but Not Sevoflurane or Desflurane Aggravates Injury to Neurons In Vitro and In Vivo via p75NTR-NF-ĸB Activation.
CONCLUSIONS:: Isoflurane but not sevoflurane or desflurane postexposure aggravates neurotoxicity in preinjured neurons via activation of p75 and NF-κB. These findings may have implications for the choice of volatile anesthetic being used in patients with or at risk for neuronal injury, specifically in patients with a stroke or history of stroke and in surgical procedures in which neuronal injury is likely to occur, such as cardiac surgery and neurovascular interventions. PMID: 25329094 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - October 17, 2014 Category: Anesthesiology Authors: Schallner N, Ulbrich F, Engelstaedter H, Biermann J, Auwaerter V, Loop T, Goebel U Tags: Anesth Analg Source Type: research