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Specialty: Biochemistry
Condition: Mitochondrial Disease

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Total 35 results found since Jan 2013.

Acrolein produced during acute kidney injury promotes tubular cell death
Biochem Biophys Res Commun. 2023 May 9;666:137-145. doi: 10.1016/j.bbrc.2023.05.029. Online ahead of print.ABSTRACTAcute kidney injury is an important global health concern as it is associated with high morbidity and mortality. Polyamines, essential for cell growth and proliferation, are known to inhibit cardiovascular disease. However, under conditions of cellular damage, toxic acrolein is produced from polyamines by the enzyme spermine oxidase (SMOX). We used a mouse renal ischemia-reperfusion model and human proximal tubule cells (HK-2) to investigate whether acrolein exacerbates acute kidney injury by renal tubular cel...
Source: Biochemical and Biophysical Research communications - May 15, 2023 Category: Biochemistry Authors: Seishi Aihara Kumiko Torisu Yutaro Hirashima Takanari Kitazono Toshiaki Nakano Source Type: research

Mitochondrial calpain-5 truncates caspase-4 during endoplasmic reticulum stress
Biochem Biophys Res Commun. 2022 Mar 31;608:156-162. doi: 10.1016/j.bbrc.2022.03.156. Online ahead of print.ABSTRACTCalpains are cysteine proteases activated in response to intracellular calcium signaling. Activated calpains regulate various cellular functions by degrading substrate molecules in a site-specific manner. Although most calpains are localized in the cytosol, we previously reported that calpain-5 exists in the mitochondria. The mitochondrial calpain-5 is activated during endoplasmic reticulum (ER) stress. However, the substrate of calpain-5, as well as the physiological significance of calpain-5 activation, has...
Source: Biochemical and Biophysical Research communications - April 10, 2022 Category: Biochemistry Authors: Yusaku Chukai Ginga Ito Masahide Konno Yuri Sakata Taku Ozaki Source Type: research

Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes
This study is the first to describe Nudt19 as regulator of hepatic lipid metabolism and potential mediator of NAFLD and T2D development.PMID:35367353 | DOI:10.1016/j.bbalip.2022.159153
Source: Biochimica et Biophysica Acta - April 3, 2022 Category: Biochemistry Authors: Sarah G örigk D Margriet Ouwens Tanja Kuhn Delsi Altenhofen Christian Binsch Mareike Damen Jenny Minh-An Khuong Katharina Kaiser Birgit Knebel Heike Vogel Annette Sch ürmann Alexandra Chadt Hadi Al-Hasani Source Type: research

Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches
Biochem J. 2021 Oct 27:BCJ20210508. doi: 10.1042/BCJ20210508. Online ahead of print.ABSTRACTMitochondrial dysfunction is implicated in Parkinson disease (PD). Mutations in Parkin, an E3 ubiquitin ligase, can cause juvenile-onset Parkinsonism probably through impairment of mitophagy. Inhibition of the de-ubiquitinating enzyme USP30 may counter this effect to enhance mitophagy. Using different tools and cellular approaches, we wanted to independently confirm this claimed role for USP30. Pharmacological characterization of additional tool compounds that selectively inhibit USP30 are reported. The consequence of USP30 inhibiti...
Source: The Biochemical Journal - October 27, 2021 Category: Biochemistry Authors: Eliona Tsefou Alison S Walker Emily H Clark Amy Rose Hicks Christin Luft Kunitoshi Takeda Toru Watanabe Bianca Ramazio James M Staddon Thomas Briston Robin Ketteler Source Type: research

3-hydroxymorphinan enhances mitochondrial biogenesis and adipocyte browning through AMPK-dependent pathway
Biochem Biophys Res Commun. 2021 Aug 30;577:17-23. doi: 10.1016/j.bbrc.2021.08.083. Online ahead of print.ABSTRACT3-hydroxymorphinan (3-HM), a metabolite of dextromethorphan, has previously been reported to have anti-inflammatory, anti-oxidative stress, and neuroprotective effects. However, its effect on energy metabolism in adipocytes remains unclear. Herein, we investigated 3-hydroxymorphinan (3-HM) effects on mitochondrial biogenesis, oxidative stress, and lipid accumulation in 3T3-L1 adipocytes. Further, we explored 3-HM-associated molecular mechanisms. Mouse adipocyte 3T3-L1 cells were treated with 3-HM, and various p...
Source: Biochemical and Biophysical Research communications - September 6, 2021 Category: Biochemistry Authors: Tae Woo Jung Eui Jin Hwang Do Hyeon Pyun Tae Jin Kim Hyun Jung Lee A M Abd El-Aty Joon Seok Bang Hyoung-Chun Kim Ji Hoon Jeong Source Type: research

Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes
In conclusion, Grp75 or Mfn2 silencing and overexpression in Huh7 cells contribute to altering MAM integrity and cholesterol storage in opposite directions, but all promote triglyceride accumulation through distinct cellular pathways. This study also highlights that besides Mfn2, Grp75 could play a central role in hepatic lipid and cholesterol metabolism in obesity and NAFLD.PMID:34419589 | DOI:10.1016/j.bbalip.2021.159030
Source: Biochimica et Biophysica Acta - August 22, 2021 Category: Biochemistry Authors: Arthur Bassot Carina Prip Buus Ana ïs Alves Olivier Berdeaux Johan Perrier V éronique Lenoir Jingwei Ji-Cao Marie-Agn ès Berger Emmanuelle Loizon Stephanie Cabaret Baptiste Panthu Jennifer Rieusset B éatrice Morio Source Type: research

SIRT3 ameliorates osteoarthritis via regulating chondrocyte autophagy and apoptosis through the PI3K/Akt/mTOR pathway.
Abstract Osteoarthritis (OA) is the most common form of joint disease. The aim of this study was to explore the functions of SIRT3 on OA pathophysiology and the mechanism involved. Rat chondrocytes and destabilized medial meniscus (DMM) rat OA model were used as in vitro and in vivo models. In addition, lentivirus and plasmid were used to overexpress SIRT3, while siRNA was applied to establish SIRT3 knockdown. IL-1β induced inflammation, apoptosis, mitochondrial dysfunction, and chondrocyte degeneration were inhibited by SIRT3 overexpression, which were enhanced in SIRT3-knockdown rat chondrocytes. Furthermore, o...
Source: International Journal of Biological Macromolecules - February 5, 2021 Category: Biochemistry Authors: Xu K, He Y, Moqbel SAA, Zhou X, Wu L, Bao J Tags: Int J Biol Macromol Source Type: research

KLF9 regulates PRDX6 expression in hyperglycemia-aggravated bupivacaine neurotoxicity.
CONCLUSIONS: The results of this study demonstrated that hyperglycemia aggravated Bup neurotoxicity by upregulating KLF9 expression, which repressed the antioxidant PRDX6 and led to mitochondrial dysfunction, ROS burst, and cell death. Understanding this mechanism may, thus, offer valuable insights for the prevention and treatment of neurotoxicity induced by LAs, especially in diabetic patients. PMID: 33547545 [PubMed - as supplied by publisher]
Source: Molecular and Cellular Biochemistry - February 5, 2021 Category: Biochemistry Authors: Li H, Weng Y, Lai L, Lei H, Xu S, Zhang Y, Li L Tags: Mol Cell Biochem Source Type: research

miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload.
CONCLUSIONS: Our results support the existence of a link between the liver cell mitochondria and miR-34a/SIRT1 signaling. Potential endogenous modulators of NAFLD pathogenesis may ultimately provide new tools for therapeutic intervention. PMID: 33098868 [PubMed - as supplied by publisher]
Source: Archives of Biochemistry and Biophysics - October 21, 2020 Category: Biochemistry Authors: Wang L, Sun M, Cao Y, Ma L, Shen Y, Velikanova AA, Li X, Sun C, Zhao Y Tags: Arch Biochem Biophys Source Type: research

Hemistepsin A protects human keratinocytes against hydrogen peroxide-induced oxidative stress through activation of the Nrf2/HO-1 signaling pathway.
Abstract Hemistepsin A, a sesquiterpene lactone compound isolated from Hemistepta lyrata, has been identified a variety of pharmacological actions including anti-hepatotoxic, anti-inflammatory and anti-cancer activities. Nevertheless, the antioxidant effects of hemistepsin A and the underlying mechanisms have not been investigated properly. Therefore, in the present study, we investigated the protective effect of hemistepsin A against oxidative stress in HaCaT human keratinocytes. The results demonstrated that hemistepsin A suppressed 500 μM hydrogen peroxide (H2O2)-induced cytotoxicity and DNA damage by blocki...
Source: Archives of Biochemistry and Biophysics - July 22, 2020 Category: Biochemistry Authors: Park C, Lee H, Noh JS, Jin CY, Kim GY, Hyun JW, Leem SH, Choi YH Tags: Arch Biochem Biophys Source Type: research

Interaction of α-synuclein and Parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of Parkinson's disease.
This study has demonstrated that iron in varying concentrations (up to 400 µM) causes an increase in α-synuclein content in SH-SY5Y cells associated with mitochondrial depolarization, decreased cellular ATP content and loss of cell viability during incubation up to 96 h. Knocking-down α-synuclein expression prevents cytotoxic actions of iron, which can also be prevented by cyclosporine A (a blocker of mitochondrial permeability transition pore). These results indicate that iron cytotoxicity is mediated by α-synuclein acting on mitochondria. Likewise siRNA mediated knock-down of Parkin causes an  accumulation of  α-s...
Source: The Biochemical Journal - February 27, 2020 Category: Biochemistry Authors: Ganguly U, Banerjee A, Chakrabarti SS, Kaur U, Sen O, Cappai R, Chakrabarti S Tags: Biochem J Source Type: research

Embelin averts MPTP-induced dysfunction in mitochondrial bioenergetics and biogenesis via activation of SIRT1
Publication date: Available online 24 January 2020Source: Biochimica et Biophysica Acta (BBA) - BioenergeticsAuthor(s): Swetha Pavani Rao, Neelam Sharma, Shasi V. KalivendiAbstractParkinson's disease (PD) is a chronic neurodegenerative disease characterized by the death of dopamine neurons of Substantia nigra pars compacta (SNpc) leading to motor deficits. Amongst the mechanisms proposed, mitochondrial dysfunction, reduced complex-I and PGC1α levels were found to correlate with the pathology of PD. As embelin is a natural product with structural resemblance to ubiquinone, exhibits mitochondrial uncoupling and antioxidant ...
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - January 26, 2020 Category: Biochemistry Source Type: research