Filtered By:
Condition: Fatty Liver Disease (FLD)
This page shows you your search results in order of relevance. This is page number 10.
Order by Relevance | Date
Total 185 results found since Jan 2013.
Ursodesoxycholic acid is an FFA4 agonist and reduces hepatic steatosis via FFA4 signaling
This study not only identified a new skeleton of FFA4 agonists, but also demonstrated that FFA4 signal was accounting for the protective effects of UDCA in the NAFLD treatment.PMID:35033554 | DOI:10.1016/j.ejphar.2022.174760
Source: European Journal of Pharmacology - January 16, 2022 Category: Drugs & Pharmacology Authors: Fangfang Xu Jun Wang Pan Wang Tao Hou Han Zhou Yaopeng Zhao Jixia Wang Yanfang Liu Xinmiao Liang Source Type: research
Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes
This study is the first to describe Nudt19 as regulator of hepatic lipid metabolism and potential mediator of NAFLD and T2D development.PMID:35367353 | DOI:10.1016/j.bbalip.2022.159153
Source: Biochimica et Biophysica Acta - April 3, 2022 Category: Biochemistry Authors: Sarah G örigk D Margriet Ouwens Tanja Kuhn Delsi Altenhofen Christian Binsch Mareike Damen Jenny Minh-An Khuong Katharina Kaiser Birgit Knebel Heike Vogel Annette Sch ürmann Alexandra Chadt Hadi Al-Hasani Source Type: research
Abietic acid alleviates endoplasmic reticulum stress and lipid accumulation in human primary hepatocytes through the AMPK/ORP150 signaling
This study investigated the impacts of AA on ER stress and steatosis in in vitro obesity models. We found that Treatment with AA reduced lipid deposition and lipogenesis-related proteins expression in human primary hepatocytes. Augmented expression of ER stress markers (phospho-eukaryotic initiation factor-2α (eIF2α) and C/EBP homologous protein (CHOP)) in palmitate-treated hepatocytes were reversed by AA treatment. Further, AA treatment increased the expression of phospho-AMPK and oxygen-regulated protein 150 (ORP150) in hepatocytes. siRNA-associated knockdown of AMPK or ORP150 expression reduced the effects of AA on no...
Source: Cell Research - April 10, 2022 Category: Cytology Authors: Tae Woo Jung Ju-Cheol Jeong Seung Yeon Park Wonjun Cho Heeseung Oh Hyun Jung Lee Ahmet Hacimuftuoglu A M Abd El-Aty Joon Seok Bang Ji Hoon Jeong Source Type: research
Upregulation of hepatic CD36 via glucocorticoid receptor activation contributes to dexamethasone-induced liver lipid metabolism disorder in mice
Toxicol Lett. 2022 May 16:S0378-4274(22)00091-1. doi: 10.1016/j.toxlet.2022.05.003. Online ahead of print.ABSTRACTGlucocorticoids such as dexamethasone (DEX) are widely prescribed to treat numerous conditions and diseases. However, glucocorticoid-induced liver lipid metabolism disorder, even nonalcoholic fatty liver disease, has caused extensive attention. Since fatty acid transporters such as CD36 and FATP play crucial roles in hepatic fatty acid uptake, this work examined their potential involvement in DEX-induced liver lipid accumulation. Chronic DEX administration (1-5mg/kg/day over 28 days) induced hepatic lipid accum...
Source: Toxicology Letters - May 19, 2022 Category: Toxicology Authors: Mingyang Chen Mengru Bai Yaodong Yi Shuanghui Lu Jun Luo Ping Li Hengbin Zhang Huidi Jiang Hui Zhou Source Type: research
Metformin protects against ethanol-induced liver triglyceride accumulation by the LKB1/AMPK/ACC pathway
CONCLUSION: Metformin protects against lipid formation in ALD by activating the LKB1/AMPK/ACC axis.PMID:35733070 | DOI:10.1007/s11033-022-07610-y
Source: Molecular Biology Reports - June 22, 2022 Category: Molecular Biology Authors: Fotian Xie Yuanming Zhong Dongmei Wang Kwok Fai So Jia Xiao Yi Lv Source Type: research
Resolvin D3 improves the impairment of insulin signaling in skeletal muscle and nonalcoholic fatty liver disease through AMPK/autophagy-associated attenuation of ER stress
Biochem Pharmacol. 2022 Aug 7:115203. doi: 10.1016/j.bcp.2022.115203. Online ahead of print.ABSTRACTResolvin D3 (RD3), an endogenous lipid mediator derived from omega-3 fatty acids, has been documented to attenuate inflammation in various disease models. Although it has been reported that omega-3 fatty acids attenuate metabolic disorders, the roles of RD3 in insulin signaling in skeletal muscle and hepatic lipid metabolism remain unclear. In the current study, we examined the role of RD3 in skeletal muscle insulin resistance and hepatic steatosis using in vitro and in vivo obesity models. In mouse primary hepatocytes, RD3 ...
Source: Biochemical Pharmacology - August 10, 2022 Category: Drugs & Pharmacology Authors: Heeseung Oh Wonjun Cho A M Abd El-Aty Cemil Bayram Ji Hoon Jeong Tae Woo Jung Source Type: research
Indole-3-acetic acid improves the hepatic mitochondrial respiration defects by PGC1a up-regulation
In conclusion, our findings uncovered that I3A increased hepatic PGC1a expression, contributing to mitochondrial respiration improvement in NAFLD.PMID:35988807 | DOI:10.1016/j.cellsig.2022.110442
Source: Cellular Signalling - August 21, 2022 Category: Cytology Authors: Chen Zhang Qingsong Fu Kai Shao Limin Liu Xiaotian Ma Fengyi Zhang Xiaodong Zhang Liying Meng ChuanZhu Yan Xiaoyun Zhao Source Type: research
Exercise inhibits JNK pathway activation and lipotoxicity via macrophage migration inhibitory factor in nonalcoholic fatty liver disease
In this study, we investigated the role of MIF in regulating JNK activation and high-fat fostered liver lipotoxicity during simultaneous exercise treatment. Fifteen mice were equally divided into three groups: normal diet, high-fat diet, and high-fat and exercise groups. High-fat feeding for extended periods elicited evident hyperlipemia, liver steatosis, and cell apoptosis in mice, with inhibited MIF and activated downstream MAPK kinase 4 phosphorylation and JNK. These effects were then reversed following prescribed swimming exercise, indicating that the advent of exercise could prevent liver lipotoxicity induced by lipid...
Source: Frontiers in Endocrinology - September 6, 2022 Category: Endocrinology Source Type: research
