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Condition: Fatty Liver Disease (FLD)

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Total 185 results found since Jan 2013.

Changes of flavin-containing monooxygenases and trimethylamine-N-oxide may be involved in the promotion of non-alcoholic fatty liver disease by intestinal microbiota metabolite trimethylamine
Conclusion, high fat and TMA could induce the expression of FMO1 and its metabolite TMAO. When FMO1 is silenced, the effects of high fat and TMA on TMAO are blocked. And the role of TMAO in NAFLD may be through the activation of UPR.PMID:35065293 | DOI:10.1016/j.bbrc.2022.01.060
Source: Biochemical and Biophysical Research communications - January 22, 2022 Category: Biochemistry Authors: Chunxia Shi Maohua Pei Yao Wang Qian Chen Pan Cao Luyi Zhang Jin Guo Wei Deng Luwen Wang Xun Li Zuojiong Gong Source Type: research

Valdecoxib attenuates lipid-induced hepatic steatosis through autophagy-mediated suppression of endoplasmic reticulum stress
This study investigated the effects of VAL on lipid accumulation and lipogenesis in human primary hepatocytes. Treatment with VAL suppressed lipid accumulation and expressions of lipogenic genes, such as processed sterol regulatory element binding proteins (SREBP1) and stearoyl-CoA desaturase-1 (SCD1) in palmitate-treated hepatocytes. Furthermore, VAL ameliorated dose-dependently palmitate-induced ER stress markers. Treatment of hepatocytes with VAL increased AMPK phosphorylation and SIRT6 expression. siRNA-mediated suppression of AMPK or SIRT6 abolished the effects of VAL on lipid accumulation, lipogenesis, and endoplasmi...
Source: Biochemical Pharmacology - March 31, 2022 Category: Drugs & Pharmacology Authors: Seung Yeon Park Wonjun Cho A M Abd El-Aty Ahmet Hacimuftuoglu Ji Hoon Jeong Tae Woo Jung Source Type: research

Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/NLRP3 pathway
Int Immunopharmacol. 2023 Jan;114:109558. doi: 10.1016/j.intimp.2022.109558. Epub 2022 Dec 21.ABSTRACTThe overuse of acetaminophen (APAP) may cause more severe hepatotoxicity in patients with non-alcoholic fatty liver disease (NAFLD). Caveolin-1 (CAV1), is an essential regulator of metabolic function, which can alleviate liver damage by scavenging reactive oxygen species (ROS). Evidence suggests that the NOD-like receptor family pyrin domain-containing 3 (NLRP3) -mediated pyroptosis is involved in the development of NAFLD. Moreover, thioredoxin-interactive protein (TXNIP) activation is a key event linking ROS to NLRP3 infl...
Source: International Immunopharmacology - January 26, 2023 Category: Allergy & Immunology Authors: Xiangfu Jiang Yu Li Dongdong Fu Tingyu You Shuai Wu Jiao Xin Jiagen Wen Yan Huang Chengmu Hu Source Type: research

GSE225616 Hepatocyte mARC1 Promotes Fatty Liver Disease
Conclusions: Collectively, our findings from human genetics, and in vitro and in vivo hepatocyte-specific mARC1 knockdown support the potential efficacy of hepatocyte-specific targeting of mARC1 for treatment of NAFLD.
Source: GEO: Gene Expression Omnibus - February 20, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE223652 Hepatocyte mARC1 Promotes Fatty Liver Disease
ConclusionsCollectively, our findings from human genetics, and in vitro and in vivo hepatocyte-specific mARC1 knockdown support the potential efficacy of hepatocyte-specific targeting of mARC1 for treatment of NAFLD.
Source: GEO: Gene Expression Omnibus - April 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPAR{alpha}-dependent and -independent pathways
In conclusion, the beneficial actions of NDGA on dyslipidemia and hepatic steatosis in ob/ob mice are exerted primarily through enhanced fatty acid oxidation via PPARα-dependent pathways. However, PPARα-independent pathways also contribute to NDGA's action to ameliorate hepatic steatosis.
Source: AJP: Gastrointestinal and Liver Physiology - January 1, 2013 Category: Gastroenterology Authors: Zhang, H., Shen, W.-J., Cortez, Y., Kraemer, F. B., Azhar, S. Tags: LIVER AND BILIARY TRACT Source Type: research

Quercetin and Allopurinol Reduce Liver Thioredoxin‐Interacting Protein to Improve Inflammation and Lipid Accumulation in Diabetic Rats
Conclusions and ImplicationsThese results demonstrate that hepatic TXNIP inhibition by quercetin and allopurinol contributes to the improvement of liver inflammation and lipid accumulation under hyperglycemia condition. Therefore, quercetin and allopurinol targeting hepatic TXNIP may have therapeutic application to prevent type 1 diabetes‐associated NAFLD.
Source: British Journal of Pharmacology - May 3, 2013 Category: Drugs & Pharmacology Authors: Wei Wang, Chuang Wang, Xiao‐Qin Ding, Ying Pan, Ting‐Ting Gu, Ming‐Xing Wang, Yang‐Liu Liu, Fu‐Meng Wang, Shui‐Juan Wang, Ling‐Dong Kong Tags: Research Paper Source Type: research

Quercetin and allopurinol reduce liver thioredoxin‐interacting protein to alleviate inflammation and lipid accumulation in diabetic rats
Conclusions and ImplicationsInhibition of hepatic TXNIP by quercetin and allopurinol contributes to the reduction in liver inflammation and lipid accumulation under hyperglycaemic conditions. The targeting of hepatic TXNIP by quercetin and allopurinol may have therapeutic implications for prevention of type 1 diabetes‐associated NAFLD.
Source: British Journal of Pharmacology - June 21, 2013 Category: Drugs & Pharmacology Authors: Wei Wang, Chuang Wang, Xiao‐Qin Ding, Ying Pan, Ting‐Ting Gu, Ming‐Xing Wang, Yang‐Liu Liu, Fu‐Meng Wang, Shui‐Juan Wang, Ling‐Dong Kong Tags: Research Paper Source Type: research

Ceacam1 Null Deletion Causes Vascular Alterations in Large Vessels.
Abstract Carcinoembryonic antigen-related cell adhesion molecule1 (CEACAM1) promotes hepatic insulin clearance and endothelial survival. However, its role in the morphology of macrovessels remains unknown. Mice lacking Ceacam1 (Cc1(-/-)) exhibit hyperinsulinemia, which causes insulin resistance and fatty liver. With increasing evidence of an association between hyperinsulinemia, fatty liver disease and atherosclerosis, we investigated whether Cc1(-/-) exhibit vascular lesions in atherogenic-prone aortae. Histological analysis revealed impaired endothelial integrity with restricted fat deposition and aortic plaque-...
Source: American Journal of Physiology. Endocrinology and Metabolism - June 25, 2013 Category: Physiology Authors: Najjar SM, Ledford KJ, Abdallah SL, Paus A, Russo L, Kaw MK, Ramakrishnan S, Muturi HT, Raphael CK, Lester SG, Heinrich G, Pierre SV, Benndorf R, Kleff V, Jaffa AA, Levy E, Vazquez G, Goldberg IJ, Beauchemin N, Scalia R, Ergün S Tags: Am J Physiol Endocrinol Metab Source Type: research

Ceacam1 deletion causes vascular alterations in large vessels
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes hepatic insulin clearance and endothelial survival. However, its role in the morphology of macrovessels remains unknown. Mice lacking Ceacam1 (Cc1–/–) exhibit hyperinsulinemia, which causes insulin resistance and fatty liver. With increasing evidence of an association among hyperinsulinemia, fatty liver disease, and atherosclerosis, we investigated whether Cc1–/– exhibited vascular lesions in atherogenic-prone aortae. Histological analysis revealed impaired endothelial integrity with restricted fat deposition and aortic pla...
Source: AJP: Endocrinology and Metabolism - August 15, 2013 Category: Endocrinology Authors: Najjar, S. M., Ledford, K. J., Abdallah, S. L., Paus, A., Russo, L., Kaw, M. K., Ramakrishnan, S. K., Muturi, H. T., Raphael, C. K., Lester, S. G., Heinrich, G., Pierre, S. V., Benndorf, R., Kleff, V., Jaffa, A. A., Levy, E., Vazquez, G., Goldberg, I. J., Tags: Articles Source Type: research